Boğaziçi Üniversitesi Tezleri: Recent submissions

  • The role of theodorant receptor coding sequence in the regulation of odorant receptor transgene expression in Zebrafish 
    Taştekin, İbrahim. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Odorant receptors constitute the largest gene family in rodents and probably in all vertebrates. In addition to detecting the odorant molecules in the outside world, odorant receptorrs are responsible for some critical ...
  • Expression of aFGF and FGF9 in the developing rat retina 
    Çayırlıoğlu, Pelin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Sciences and Engineering, 1995., 1997.)
    aFGF, an FGF gene family member, has been postulated to be important in the physiology and development of vertebrate retina. The distribution and relative levels of aFGF mRNA in the external photoreceptors layer, and in ...
  • Involvement of SIK2 in FGF2 signal regulation via RAF-1 and generation of mutants for identification of phosphorylation sites on SIK2 by ERK 
    Akay, Özden. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Müller cell proliferation is induced by FGF2 signaling via Ras/MAPK pathway through rapid and transient ERK1/2 activation. Salt inducible kinase 2 (SIK2), a serine/threonine kinase, is a novel regulator in this context. ...
  • A privileged hunter: role of NLRP7 in immune privilege 
    Demiröz, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    NOD-like receptors (NLRs) are a family of cytoplasmic receptors with members regulating apoptosis and inflammation. NLRP7 is a novel PYRIN domain containing NLR family member and its functions are still under investigation. ...
  • Identification of the role of a novel cell adhesion molecule, unzipped, in mediating neuron-glia interactions in drosophila 
    Zülbahar, Selen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The intricate but still precise pattern of brain circuitry is unquestionably the most complex feature of both vertebrates and invertebrates. How that complex circuitry develops has been the subject of intense study for ...
  • A FLY's view of salt inducible kinases: a synergistic tumorigenesis model 
    Sayın, Sercan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The recent explosion of data generated by high-throughput assays on cancer necessitated reliable and fast in vivo models for evaluation new catalogue of candidate genes as tumor suppressors or proto-oncogenes and their ...
  • Mutation, exome sequencing and linkage analyses in Turkish CMT families 
    Erdoğan, Alperen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Charcot-Marie-Tooth disease (CMT) also known as hereditary motor and sensory neuropathy (HMSN) is the most frequent inherited neuropathy. The patients with CMT generally have distal muscle weakness and atrophy in the ...
  • Identification and docking analysis of allatostatin receptor in Carausius morosus 
    Duan, Burçin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Allatostatin receptors (AlstRs) with their ligands (ASTs) play role in insect development, by inhibiting the production of Juvenile hormone. This thesis project uses the advances in structure-based studies and single-molecule ...
  • Transgenic analysis of the Zebrafish OR101-1 gene promoter 
    Söğünmez, Nuray. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The repertoire of olfactory receptors constitutes the largest gene families in humans and in other vertebrates. Typically, olfactory sensory neurons only express a single member of the large genomic repertoire and only one ...
  • Disease gene identification via linkage analysis and exome sequencing 
    Güven, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Understanding the genetic basis of hereditary diseases elucidates the molecular mechanisms underlying disease manifestations and uncovers valuable information about gene function. Consanguineous families are very useful ...
  • Genetic diversity of almonds (Prunus dulcis) of Datça 
    Kaptan, Damla. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Anatolia’s agricultural biodiversity, which has evolved with the contributions of many different cultures over thousands of years, is today being rapidly eroded as a result of climate change, population growth, globalization ...
  • Identification and in vivo analysis of putative Wnt target genes with effective roles in cancer 
    Even, İpek. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    One of the most common driving forces in hepatocellular carcinoma (HCC) is the aberrant activation of the Wnt/β-catenin signaling due to the accumulation of mutant β-catenin in the cell. Our group previously detected several ...
  • Detection of DNA duplications in charcot-marie-tooth type 1 (CMT1) patients by DNA analysis 
    Bissar-Tadmouri, Nisrine. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1997., 1997.)
    Charcot-Marie-Tooth neuropathy (CMT), also known as Hereditary Motor and Sensory Neuropathy (HMSN), is a heterogeneous group of inherited diseases of peripheral nerves. It is estimated that 112500 persons have a form of ...
  • Schizophrenia: another emphasis of ERBB4 and NRG1 impact on disease development 
    Ağım, Zeynep Sena. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Schizophrenia, which is one of the most commonly reported illnesses among all psychiatric disorders, is defined as a complex disease; this implicates that it does not show a simple Mendelian pattern of inheritance. The ...
  • Two faces of ASC : central innate immunity adaptor ASC turns into melanoma ally and novel mechanism demistifying dsRNA induced NLRP3 inflammasome activation through Bax/Bak mediated cell death 
    Özkurede, Varol Ulaş. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    In this study, by specifically focusing on the role of ASC in melanoma and NLRP3 activation in response to double stranded RNA, we try to provide answers to more general but basic questions: “How and why would cancer cells ...
  • Virulence and genetic diversity of Colletotrichum Lindemuthianum isolates collected from common bean varieties of Turkey 
    Küçükyan Canseven, Serli. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    The common bean (Phaseolus vulgaris L.) is the most widely distributed and consumed legume species of the genus Phaseolus. As one of the major producer in the world, common bean production is highly dominated by the Black ...
  • Possible interactors of alsin and effects of its expression on four motor neuron disease-related proteins 
    Çobanoğlu, Gönenç. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Motor neuron disorders, characterized by selective motor neuron degeneration, consist of a large group of diseases with overlapping genes and common pathological mechanisms. Mutations in ALS2, associated with three types ...
  • Co-expression of odorant receptor genes in zebrafish 
    Atasoy, Arif Murat. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Olfactory receptors constitute the largest G-Protein-Coupled Receptor family in humans and in other vertebrates. Olfactory receptor genes are expressed in the olfactory sensory neurons in the olfactory epithelia and are ...
  • Role of IroC in the fly olfactory system 
    Talay, Mustafa. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Sensory neurons, such as the visual and olfactory neurons, tend to express only one sensory receptor per neuron in order to prevent sensory overlap and then send their axons to particular target regions in the brain to ...
  • ERK, AKT and PKA as regulatory kinases of SIK2 in FGF signaling in muller cells 
    Ejder, Funda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    FGF2 dependent retinal Müller cell proliferation is elicited mainly via activation of Ras/MAPK pathway. Phosphorylation/dephosphorylation of intermediates is one of the key mechanisms for the transient and rapid regulation ...

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