Boğaziçi Üniversitesi Tezleri: Recent submissions

  • SIK2 involvement in dowregulation of FGF signaling through Gab1 and Raf1 
    Sert, Yeliz Yılmaz. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Proliferative response of Müller cells to FGF2 is propagated via Ras/MAPK pathway, and involves rapid and transient ERK1/2 activation. Results from our laboratory implicate SIK2 in the regulation of FGF2 signaling via ...
  • Cloning and characterization of novel nod like receptors as cytoplasmic immune sensors 
    Gültekin, Yetiş. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    NOD like receptors recognize infection and cellular damage. They are characterized by an N terminal protein interaction domain, central oligomerization domain, termed nucleotide binding domain and leucine rich repeat domain ...
  • Genetically accurate models of SOD1-based ALS in Drosophila melanogaster 
    Deniz, Pınar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    ALS is a late onset, rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Generally, 5-10% of ALS patients have a family history (fALS), ...
  • The impact of mutant alsin protein on motor neuron models and the effects of alsin gene knock-down on motor protein genes 
    Lahut, Suna. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Alsin is a ubiquitously expressed protein with the highest levels in the central nervous system. Mutations in the alsin gene have been associated with several juvenile onset recessive motor neuron diseases. Nine out of 12 ...
  • The molecular basis of alpha-thalassemia in Turkey: |establishment and application of PCR-based methods 
    Taştan, A. Özlem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1996., 1996.)
    As in many other Mediterranean countries, hemoglobinopathies, especially thalassemias pose a major health concern in the Turkish population. Alpha-thalassemias, which may be the most common genetic disorders of human being, ...
  • Linkage analysis and candidate gene approach in three disorders 
    Yıldırım, Yeşerin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    Genetically inherited diseases are powerful resources for defining new gene functions. Genetic linkage analysis is the tool used for identifying the locus/loci harboring the gene(s) responsible for a particular disease. ...
  • Exclusion of autosomal recessive hereditary spastic paraplegia loci in Turkish families 
    Özeş, Burçak. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Hereditary spastic paraplegias (HSPs), also known as Strümpell-Lorrain disease, describe a heterogeneous group of genetic neurodegenerative disorders. The main feature of the disease is progressive spasticity in the lower ...
  • Importance of ASC expression for melanoma tumorigenesis in vivo and a role for inflammasome activation in apoptosis induction 
    Çifdalöz, Metehan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    ASC is an adaptor protein which is capable of binding to numerous partners due to its two oligomerization domains, PYRIN and CARD. Its involvement in the inflammasome complex as an essential adaptor, in the regulation of ...
  • Characterization of genes involved in photoreceptor differentiation 
    Öztürk, Arzu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    The one receptor - one neuron rule is a common phenomenon observed in sensory organs. In the Drosophila eye, each photoreceptor expresses one of six different rhodopsin genes. The expression patterns of inner photoreceptors ...
  • Identification of protein partners of acidic calponin 
    Dindar, Emine. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    The up-regulation of acidic calponin gene in different brain tumors has been revealed by a bioinformatic tool termed Oncoreveal. Expression pattern has been further confirmed with an independent brain tumor panel by our ...
  • Locus and gene search in three disorders 
    Hazan, Renin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Identification of genetic defects associated with hereditary diseases is important in understanding cellular mechanisms and molecular etiology of diseases, developing diagnostic tests and novel therapeutic techniques. In ...
  • Class restriction in odorant receptor gene regulation 
    Tınaztepe, Emir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Odorant receptors which partake in the detection of both water-soluble and airborne chemicals constitute the largest family of seven-transmembrane G-Protein-Coupled Receptors in the majority of vertebrates. Since their ...
  • Establishment of primary human skin cell culture and soft agar transformation assay 
    Sümer, Burcu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The skin, the largest organ of the human body, is a complete closed system with various functions, including physical protection from the exterior hostile environment, sensing outside signals via its complex sensory system ...
  • A study for the detection of known and novel mutations in the cystic fibrosis transmembrane conductance regulator gene 
    Kılınç, Okyay. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1996., 1996.)
    Cystic fibrosis (CF) is one of the most common and severe autosomal recessive genetic disorders worldwide. It results from mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). ...
  • Characterization of C170RF45 as a novel target of the Wnt/β-catenin pathway 
    Şeker, Tuncay. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    β-catenin is a key component of Wnt pathway which plays an important role in tumorigenesis. In our previous study, candidate genes regulated byWnt/ β-catenin/TCF pathway were identified in hepatocellular carcinoma-derived ...
  • Temporal and comparative analysis of genes that play a role in brain vascular development 
    Özkan, Abdulkadir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Arteriovenous malformations (AVMs) are direct abnormal connections of arteries and draining veins without a capillary bed. AVMs, in which normal blood flow is interrupted, carry high risk of bleeding throughout life. They ...
  • Myotonic dystrophy: application of a novel triplet-repeat-primed-pcr approach to Turkish DM patients and molecular analysis of a large Turkish kindred with Von Hippel-Lindau disease 
    Eruslu, Didem. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Myotonic Dystrophy (DM) is an autosomal dominant neuromuscular disease with multisystemic effects. DM1 and DM2 are two clinically similar types of DM that are caused by different mutations on different genes. DM1, the more ...
  • Molecular genetic analysis of benign epilepsy syndromes 
    Kayserili, Melek Aslı. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Generalized Epilepsy with Febrile Seizures Plus (GEFS+) and Benign Familial Infantile Seizures (BFIS) are some of the benign epilepsy syndromes. GEFS+ is a collection of phenotypes that show febrile seizures beyond the age ...
  • Identification of novel proteins that interact with BR13, a putative transcriptional target of the Wnt/β-catenin signaling pathway 
    Akiva, İzzet. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The Wnt/β-catenin signaling pathway is an evolutionary conserved pathway which has important functions in vertebrate early development, axis formation, cellular proliferation and morphogenesis. The activation of this pathway ...
  • Verification of putative novel Wnt/ β-catenin pathway targets using alternative effectors 
    Aslan, Tolga. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The Wnt/β-catenin pathway plays important roles in embryogenesis, development and tissue homeostasis in adult organisms. Mutations in almost any member of this pathway have been associated with a disease including Alzheimer’s ...

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