Boğaziçi Üniversitesi Tezleri: Recent submissions

  • Disease gene search via linkage mapping and exome sequencing 
    Köroğlu Altok, Çiğdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of disease genes has a key importance in understanding the molecular mechanisms of disease pathogenesis as well as in expanding our knowledge on gene function. Linkage mapping is a powerful method to identify ...
  • Cloning, expression and purfication of the recombinant DNA polymerase I from the hyperthermophilic bacteria geobacillus anatolicus 
    Çağlayan, Melike. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2005., 2005.)
    The DNA polymerase I gene of a recently described Geobacillus species, Geobacillus anatolicus from a terrestrial hydrothermal vent has been cloned and expressed in Escherichia coli. Evolutionarily conserved regions of DNA ...
  • Linkage and exome sequence analyses to identify disease genes 
    Ayhan, Özgecan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of the genetic basis of a hereditary disease provides important information about the molecular mechanism of the disease and the function of the gene and could contribute to the development of therapeutic ...
  • Development of a drosophila CMT4A model using imago approach 
    Yıldırım, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. So far, approximately 50 genes and loci have been associated with CMT. Mutations in ganglioside-induced differentiation-associated protein ...
  • Identification of interaction partners of unzipped, a novel cell adhesion molecule 
    Akgün, Gamze. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The brain is unquestionably the most sophisticated organ in bodies of many organisms. Establishment of this complex architecture depends on the ability of axons to find their proper targets. On their way to their synaptic ...
  • SIK3 involvement in FGF2 signaling in Müller cells 
    Koca, Yıldız. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    FGF2 stimulation of Millier cells regulates several processes including cell proliferation and survival by triggering the activation RaslMAPK and PI3K1 Akt pathways. Data from our lab indicate that serine/threonine kinase ...
  • Development of a drosophila CMT model via overexpression and knocking-in of GDAP1 gene 
    Akyüz, Hüseyin Kaya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is one of the most common inherited disorders of the nervous system. Known also as hereditary motor and sensory neuropathy, this disease is characterized by distal sensory loss, muscle ...
  • Characterization of IRF4 dependency in melanoma cell lines 
    Ayhan, Mustafa Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Interferon Regulatory Factor 4 (IRF4, also known as MUM1, LSIRF, NFEM5, and ICSAT) is a transcription factor with important regulatory roles on B-cell matura-tion and differentiation. Although the first identification of ...
  • Studying the role of phosphorylation of bacterial protein synthesis elongation factor Tu 
    Kaplan, Uğur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu (EF-Tu) plays a crucial role of carrying aminoacylated-tRNA molecules to the ribosome during the elongation phase of protein synthesis. Being a guanine nucleotide binding protein, EF-Tu is inactive ...
  • Identification of C17ORF45 protein and the effects of its snornas on cell cycle 
    Kapıkıran, Vahap. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The Wnt / β-catenin signaling has many important roles in cellular responses and dysregulation of this pathway are linked to tumor formation. Priorly, SAGE and microarray analyses were performed in our laboratory in order ...
  • Genetic analyses in Seckel syndrome and azoospermia 
    Korur, Serdar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2004., 2004.)
    The autosomal recessive genetic disorders Seckel syndrome and azoospermia were studied. In Seckel syndrome, the two known loci were tested for linkage in 15 Seckel families. In addition, four ATR interacting and fifteen ...
  • The functional role of ASP50 in protein synthesis elongation factor Tu 
    Baş, Levent. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu is an essential enzyme responsible for delivering aminoacyltRNA's to ribosomal A-site during protein synthesis. In its active GTP-bound state, it forms an EF-Tu · GTP · aminoacyl-tRNA ternary complex ...
  • Development and molecular analysis of CMT4B1 drosophila model 
    Kılınç, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. Among about 40 genes associated with the disease, MTMR2 loss-of-function mutations are classified as CMT4B1 subtype. ...
  • Evaluation of exome sequencing data & mutation screening in GDAP1, GJB1, MPZ, NDRG1 and PMP22 genes in Turkish CMT patients 
    Sıvacı, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease which is an inherited peripheral neuropathy is an excellent candidate to be analyzed by exome sequencing because of its locus heterogeneity and low prevalence. Protein-coding regions, ‘the ...
  • Characterization of a novel R7-specific gene in the drosophila visual system 
    Kaçmaz, Güner. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The proper functioning of the nervous system depends on the correct specification of many different cell types and the establishment of proper connections between neurons during development. The visual system of Drosophila ...
  • Elucidating the role of foxo transcription factors on lithium induced growth arrest in hepatocellular carcinoma cells 
    Şekerci, Esra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Lithium is one of the most effective drugs for the treatment of bipolar disorder for years. Many studies have shown that lithium has neuroprotective effect and has acapacity to inhibit cell proliferation. Specifically, it ...
  • Structural aspects of ASC speck formation and its potential novel functions 
    Sahillioğlu, Ali Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
  • The genetics of sporadic ALS: the first Turkish GWAS and novel SNP and CNV association 
    Uyan, Özgün. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Selective degeneration of both lower and upper motor neurons located in the brain cortex, brainstem and ventral horn of the spinal cord result in amyotrophic lateral sclerosis (ALS). ALS is the most frequent late-onset ...
  • Genetic factors contributing to ALS in Turkey: ATXN2 polyQ repeat expansions and SNP/CNV associations 
    Ömür, Özgül. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    ALS is the most frequent motor neuron disorder and so far no cure has been developed for this devastating disease. ALS is characterized by the selective loss of both the upper motor neurons of the motor cortex and the lower ...
  • Genetically accurate models of SOD1-based ALS in drosophila: validation and characterization 
    İskender, Ceren. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    SOD1 has been a unique target of ALS research as the first identified gene of the disease; since 20 years, SOD1 has not been related to any other disease unlike other ALScausing genes. There are more than 160 mutations ...

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