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Ph.D. Theses: Recent submissions

Now showing items 21-40 of 87

Lesion detection in MR mammography: NMITR maps, dynamic and morphological descriptors

Ertaş, Gökhan. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2007., 2007.)

In this thesis, algorithms, methods and techniques for dynamic contrast-enhanced magnetic resonance mammography (DCE-MRM) have been investigated to maximize sensitivity, specificity and reproducibility of breast cancer ...
Biomimetic polydimethylsiloxane cell substrate design for enhanced in vitro cellular behavior

Öztürk, Meftune Özgen. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2021., 2021.)

Recent developments in cell-based therapies and toxicological investigations re veal the need for well-designed, stable and flexible cell substrates. Mimicking the natu ral cellular microenvironment by altering cell substrate ...
Customizable TDI-based whole body X-ray scanner

Durmaz, Fevzi Aytaç. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

Medical X-ray systems are the gold standard in certain cases of medical diagnostics for over 100 years. The main scope of our studies is to develop a new full-body X-ray scanner device using line scanner detectors, and a ...
Development of a modular software platform for digital X-ray systems

Brusan, Altay. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

Health centers require full-body X-ray imaging in their busy trauma departments. Full-body X-ray scans are required for bone examinations such as diagnosis of osteoarthritis and degenerative changes in the lumbar spine. ...
Development of a hybrid methodology for investigation and manipulation of functional mechanisms of biological macromolecules with a focus on non-globular proteins

Acar, Burçin. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2021., 2021.)

Anisotropic Network Model (ANM) guided Langevin Dynamics (LD) method (ANM-LD) is an enhanced sampling algorithm, in-house developed to study conformational changes between functional protein structures, that are not possible ...
A macro-structural characteristic of brain white matter :|'dispersion' with its clinical and technical applications

Demir, Ali. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

The main goal of this thesis is to find distinct macro-structural characteristics of brain white matter in the case of psychosis, where development of diagnostic imaging measures is necessary for early diagnosis and ...
Psychophysical evaluation of a sensory feedback system for prosthetic hands

Karakuş, İpek. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

In this study, a vibrotactile sensory feedback system was designed and tested in accordance with the discrete event-driven sensory feedback control paradigm. Novel approaches were applied in terms of data processing and ...
Development of an injectable polymer-calcium phosphate cement composites for bone substitution

Demir, Öznur. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

Since the discovery of injectable calcium phosphate (CaP) cements, they are widely used to fill irregularly shaped bone defects. This created an alternative to more invasive methods such as use of autografts, allografts, ...
Characterization of Au, Au/GO and Au/rGO surfaces for carotid endothelial cell proliferation by electrical impedance spectroscopy method

Şimşek, Fatma Gülden. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

Endothelium dysfunction may be the cause of cardiovascular diseases such as heart attack, aneurysm, or atherosclerosis. Thus understanding endothelial cell properties helps explaining the reasons and treatment of cardiovascular ...
Identifying CT image radiomic biomarkers for predicting immunotherapy response of non-small cell lung cancer patients

Tunalı, İlke. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

Checkpoint blockade immunotherapy (IO) provides improved long-term survival in a subset of advanced stage non-small cell lung cancer (NSCLC) patients. However, highly predictive biomarkers of IO response are an unmet ...
Models to assess the quality of stored erythrocyte suspensions by diffuse reflectance measurements

Can, Osman Melih. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

Legislation in transfusion medicine define hemolysis level as the quality measure for erythrocyte suspensions (ES). Since the golden standard test for hemolysis is destructive and causing wastage of units, the hemolysis ...
Targeting tumor microenvironment to improve immunotherapy responses

Damgacı Ertürk, Sultan. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2020., 2020.)

The acidic microenvironment of solid tumors has suppressing effects on immune cells, accordingly immunotherapy responses. This thesis composed of two main studies as measuring tumor pH with non-invasive methods using ...
Biological effects of electromagnetic fields at mobile telecommunication frequencies

Yürekli, Ali İhsan. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2006., 2006.)

The increasing use of cellular phones and increasing number of base stations are becoming awidespread source of non-ionizing electromagnetic radiation. The immediate biological effectof electromagnetic (EM) radiation is ...
Strategies to increase photodynamic theraph efficacy on conventional and complex in vitro cancer models

Ruhi, Mustafa Kemal. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2019., 2019.)

Cancer is one of the leading causes of death worldwide. Due to the side-eﬀects and ineﬃcacy of the conventional cancer treatment methods, alternative modalities are researched. Oneofthealternatives, PhotodynamicTherapy(P ...
The effects of synaptic modulation on the vibrotactile responses of somatosensory cortical neurons studied by microinjection, microstimulation and a computational model

Vardar, Bige. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2019., 2019.)

In this thesis, we studied the eﬀects of synaptic modulation on the vibrotactile responses of somatosensory cortical neurons by three diﬀerent methods: microinjection, microstimulation and a computational model. First, we ...
Application of newborn jaundice determination and design of a noninvasive bilirubinometer

Karamavuş, Yunus. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2019., 2019.)

Newborn jaundice (hyperbilirubinemia), which is seen in 65% of healthy newborns, is usually a harmless condition and passes without any treatment. However, 5% of the jaundiced babies develop kernictures which may cause ...
Optimizing the accuracy of tumor segmentation in pet for radiotherapy planning using blind deconvolution method

Koç, Alpaslan. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2019., 2019.)

Tumor segmentation accuracy greatly aﬀects the eﬀectiveness of radiotherapy procedures. Maximizing the segmentation accuracy has high medical signiﬁcance in order to deliver the highest radiation dose to the target volume ...
Assessment of local muscle deformations using multi-modal imaging and finite element modeling

Pamuk, Uluç. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2019., 2019.)

In vivo assessment of muscle deformations, including inﬂuence of non-muscular tissues such as NVTs, aponeuroses, fasciæ or overlying skin, is key due to functional relevance of tissue connectivity within limb. In integral ...
Design of a dynamic optical property monitoring system: Studying the effect of temperature change

Kara, Ercan. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2018., 2018.)

In laser applications, it is necessary to know the tissue optical properties before the treatment and how they change during the treatment. The optical monitoring system with double-integrating-sphere having a special ...
Thin film based semi-active RF marker desing for interventional MRI devices

Baysoy, Engin. (Thesis (Ph.D.)-Bogazici University. Institute of Biomedical Engineering, 2018., 2018.)

Compared to the other imaging modalities Magnetic Resonance Imaging (MRI) system has many advantages. There is a great demand to carry out interventional cardiovascular procedures under MRI scanner. However, the lack of ...

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