• Characterization of GPR139 and investigating its possible role in brain development 

  Aslan, Tolga. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

  G protein coupled receptors are a large family of cell surface receptors and are involved in a plethora of physiological functions from vision to various neuronal func tions. They have been a major target in the pharmaceutical ...
• From mutations to disease mechanism in Rett Syndrome, breast cancer, and congenital hypothyroidism 

  Barış, İbrahim. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)

  Epidemiological studies provide the correlative data to understand the etiology of human inherited diseases and develop efficient genetic testing assays. Additionally, the accumulated data of genetic and epigenetic findings, ...
• From genome scan to disease gene identification 

  Uğur, Sibel Aylin. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)

  In the framework of this study, genome wide linkage scans of the following five inherited disorders were evaluated with parametric programs and suggestive loci were subsequently investigated with fine-mapping studies and ...
• Investigation of molecular signals regulating cell proliferation and neurogenesis in the intact and injured Zebrafish (Danio rerio) olfactory epithelium 

  Demirler, Mehmet Can. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)

  The zebrafish olfactory epithelium (OE) can recover from the near total loss of olfactory sensory neurons (OSNs) within only a week when the OE is damaged by external causes. This remarkable neurogenic activity depends ...
• SIK2 expression in retinal cells and its possible involvement along with PKA in FGF9 signal transduction 

  Özmen, Yeşim. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

  FGF signal transduction pathway activates a cascade of kinase and phosphatase dependent phosphorylation and dephosphorylation events. The pathway is subject to tight control mechanisms through negative feedback exerted by ...
• Effects of extremely low frequency electromagnetic fields on caspase activities 

  Ozansoy, Mehmet. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

  All life on Earth is bathed in a sea of natural low-frequency electromagnetic fields from conception to death. Since the World Health Organization (WHO) launched its international electromagnetic fields (EMF) project in ...
• Genetic and molecular analyses of Turkish patients with pelizaeus - merzbacher disease 

  Bilir, Birdal. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)

  Pelizaeus-Merzbacher disease (PMD) is a rare inherited leukodystrophy with Xlinked recessive segregation. About 80 per cent of patients with PMD have been associated with mutations of the PLP1 gene on Xq21.3-Xq22 which ...
• Omics comparison of two common bean genotypes and study of pvSPS4 knockdown in composite plants under saline conditions 

  Niron, Harun. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)

  Soil salinity is an abiotic stress factor that limits global agricultural output. Common bean is an important protein source in developing countries, however sensitive to salinity. To understand the underlying mechanism ...
• Cellular and molecular analysis of regenerative neurogenesis in the zebrafish (Danio rerio) olfactory epithelium 

  Kocagöz, Yiğit. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)

  The olfactory epithelium (OE) has a high regenerative capacity that ensures the lifelong replacement of olfactory sensory neurons (OSNs). Different modes of neurogen esis originate from the selective activity of two distinct ...
• The effect of nNav1.5 gene expression in breast cancer metastasis 

  Yamacı, Rezan Fahrioğlu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

  Breast cancer is the most common cancer among women. Its metastasis is lethal that can not be detected at microscopic levels using current techniques. Thus, there is need for reliable early metastasis markers. Neonatal ...
• Investigation of novel recessive causative genes and gene / allele frequency for CMT disease in Turkey 

  Candayan, Ayşe. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)

  Inherited peripheral neuropathies are a group of genetic disorders of the periph eral nervous system. The most common type is called Charcot-Marie-Tooth (CMT) disease that constitutes an interesting research focus due to ...
• Functional and structural insights into a novel insect G protein-coupled receptor, allatostatin receptor type C of pine processionary moth 

  Shahraki, Aida. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2020., 2020.)

  Insect neuropeptides regulate di erent aspects of insect physiology. They exert their function via binding to their cognate receptor belonging to Class A G protein coupled receptors (GPCRs). Neuropeptide receptors are ...
• Divergent functions of NLRP7 in embryogenesis, inflammation and oncogenesis 

  Garipcan, Aybüke. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

  NLRP7 is a novel protein about which we have limited information. To date, mutations in NLRP7 gene have been associated with recurrent Complete Hydatidiform Mole (RCHM) and NLRP7 is accepted to be the first causative gene ...
• Neuropeptidome and gpcrome of stick insect: Specific structural and functional aspects of allatostatin receptor 

  Duan, Burçin. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

  The arthropods constitute about three-quarters of the world’s animal species. The molecules that regulate many physiological events, from the feeding to develop ment, from locomotion to the social behavior, from the ...
• Functional enrichment methodology for analyzing omics data to study the aetiology of rare diseases 

  Saygı, Ceren. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

  Rare diseases (RDs) are a large and diverse group of disorders and defined by low prevalence, in other words, it is any disease that affects a small percentage of the population. According to OMIM and Orphanet, ~7000 ...
• The molecular landscape of ALS in Turkey: A multifaceted approach to the complex genetics of ALS 

  İskender, Ceren. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

  Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease (NDD), characterized by degeneration of both upper and lower motor neurons leading to muscle wasting. With an incidence of two and a prevalence ...
• Identification on new loci, genes, and mutations responsible for hereditary spastic paraplegia 

  Özeş, Burçak. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

  Hereditary Spastic Paraplegia (HSP), characterized by lower limb spasticity and progressive weakness, is a group of inherited neurodegenerative disorders. 47 of the 63 genes responsible for HSP, have been associated with ...
• Disease gene discovery by linkage mapping and exome analysis 

  Bölükbaşı, Esra Yıldız. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

  Disease gene identification is an important area in genetics. Consanguineous marriages are very common in some populations and lead to emergence of rare diseases. To uncover the functions of our genes and the molecular ...
• Proteomics based search for novel SIK2 substrates involved in endoplasmic reticulum homeostasis 

  Şeker, Tuncay. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)

  As a result of high calorie diet and low physical activity, obesity has become widespread worldwide in the last two decades. Obesity, which is a risk factor for many diseases including diabetes, hypertension, and fatty ...
• Molecular analysis of the factor IX gene in the Turkish population 

  Onay, Ü. Venüs. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1999., 1999.)

  Hemophilia B, the third common hereditary coagulopathy, is very heterogeneous at both phenotypic and genotypic levels. This X-linked recessive disease is caused by the production of either reduced amounts or functionally ...

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