Browsing Ph.D. Theses by Title

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  • Fermentation and recovery of EcoRI endonuclease using two different genetically engineered E.coli strains 
    Yıldır (Tamerler), Candan. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1997., 1997.)
    A small scale procedure developed for the purification of EcoRI restriction enzyme has been applied to two different overproducing E.coli strains. The final purification yields obtained are 1.3x105 U/g cells for E.coli ...
  • Fermentation characteristics of four genetically engineered Saccharomyces cerevisiae strains 
    Birol (Deniz), Gülnur. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1997., 1997.)
    The production of ethanol from starch has been investigated in four genetically modified Saccharomyces cerevisiae strains (YPG/AB, YA7, YPG/MM and YPB-G). Three of the four strains produce the Aspergillus awamori glucoamylase ...
  • From yeast to human : unraveling sphingolipid metabolism through macroscopic and microscopic analyses 
    Kavun Özbayraktar, Fatma Betül. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Sphingolipids are both structural and regulatory components of the cell, where they control processes decisive in cell’s fate. The pharmacological manipulation of the sphingolipid metabolism in cancer therapeutics necessitates ...
  • Integrated analysis of metabolome profiles and gene expression in respiratory deficient deletion mutants of Saccharomyces Cerevisiae 
    Pir, Pınar. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2005., 2005.)
    A study on transcriptional and metabolic response of S. cerevisiae cells toenvironmental and genetic perturbations was made. Deletion mutants with BY4743backgound were used. Homozygous deletion mutants ho/ho (reference ...
  • Investigation of aging (chronological life span) in S. Cerevisiae by systems biology approaches 
    Yücel, Esra Börklü. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Social Sciences, 2013., 2013.)
    One of the major goals of biological systems research is to improve the human condition and quality of life. Aging is probably the most peculiar phenomenon that a cell, tissue and even an organism experiences. Although it ...
  • Investigation of infection mechanisms through pathogen-human protein-protein interactions by bioinformatics approaches 
    Tekir, Saliha Durmuş. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Social Sciences, 2013., 2013.)
    Since ancient times, even in today's modern world, infectious diseases cause lots of people to die. The interactions between the proteins of infectious microorganisms, pathogens and their human hosts allow the microorganisms ...
  • Investigation of the effect of plasticity on the prediction of genetic interactions and phenotypes in Saccharomyces Cerevisiae 
    Dikicioğlu, Duygu. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Prediction of phenotype from genome-scale high-throughput network and component information still remains a challenge for systems based approaches in biological research. The enhancement of our power of prediction of ...
  • Knowledge extraction for organometallic perovskite solar cells from published data in literature 
    Odabaşı, Çağla. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Orgonolead halide perovskite solar cells (PSCs) have been attracted great attention in recent years. This rapid progress is due to excellent light absorption and charge-carrier mobilities of the perovskite materials besides ...
  • Knowledge extraction from experimental and computational data for selective CO oxidation and water gas shift reaction using data mining techniques 
    Günay, Mehmet Erdem. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The objective of this dissertation is to apply various data mining techniques for knowledge extraction from experimental and computational data to improve catalyst design and testing conditions for selective CO oxidation ...
  • Mixed-resolution elastic network models for biological supramolecules 
    Levitas, Ayşe Özge Kürkçüoğlu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Mixed coarse-graining approach has been recently introduced to the elastic network model to enable the modeling of a protein’s native conformation with regions of high- and low-resolution. In this model, each node of the ...
  • Modeling of nanoparticle-membrane interactions 
    Gül, Gülşah. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Understanding the toxicity behavior of NPs is of great importance to ensure efficient drug delivery to intracellular targets without causing cytotoxicity, to measure the long-term effects of nanoparticles (NPs), and to ...
  • Network topology and dynamic data analysis in saccharomyces cerevisiae 
    Karabekmez, Muhammed Erkan. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Biological systems which can be represented as networks and graphs are highly dynamic and responsive to environmental and genetic perturbations in a time dependent manner. These networks are hierarchically organized and ...
  • Optimal resilient retrofit design of heat-exchanger networks 
    Konukman, Alp Er Şevki. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1996., 1996.)
    A new index, called Design Resiliency Index, which numerically indicates the size of feasible region in terms of uncertain source-temperature or flowrates for the fixed design parameters of a network structure, is proposed. ...
  • Peptide drugs against antibiotic resistant bacteria 
    Alaybeyoğlu, Begüm. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Membrane active peptides have found great interest as drug candidates due to their unique mode of action and availability in nature. In the past 20 years, beta lactamase-mediated antibiotic resistance has become a lethal ...
  • pH and temperature dependence of the rate of dissolution of AgIO3 
    Uyanık, Ömer Lütfi. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1984., 1984.)
    In this thesis a theory based ona dissolution model was checked experimentally. The theory which is developed by B.V. Enüstün expresses the initial rate of dissolution for a 1:1 type ionic solid in terms of the model ...
  • Photocatalytic hydrogen production over ionic liquid coated semiconductors 
    Can, Elif. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    The objective of this thesis is to develop active and stable dye sensitized and ionic liquid (IL) encapsulated photocatalysts for hydrogen production, and to investigate the roles of photocatalysts constituents on hydrogen ...
  • Production of Taq I restriction and modification enzymes by using two different expression systems 
    Toksoy, Ebru. (Thesis (Ph.D)- Bogazici University. Institute for Graduate Studies in Science and Engineering, 2000, 2000.)
    Taq I restriction-modification system has been cloned and expressed using two different expression systems. In the first system, Taq I restriction endonuclease was expressed as a fusion protein with the maltose-binding ...
  • Recognition and binding processes in HIV-1 protease 
    Özer, Asuman Nevra. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    HIV-1 protease is a drug target against AIDS and understanding its molecu- lar recognition processes is important in development of drugs. Here, the combined computational methodologies used put three different perspectives ...
  • Segmental orientation and conformational dynamics of polymer chains 
    Haliloğlu, Türkan. (Thesis (Ph.D)- Bogazici University. Institute for Graduate Studies in Science and Engineering, 1992., 1992.)
    Various remarkable features of polymers, as compared with metallic and inorganic materials, arise from the fact that macromolecules can take up various conformations. The study of macromolecular conformations and dynamics ...
  • Stoichiometric models in metabolic systems biology of yeast 
    Çakır, Tunahan. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    A system-level analysis of Saccharomyces cerevisiae metabolism was performed through integration of stoichiometric modeling and high-throughput ‘omics’ data. A bridge between metabolic networks and transcriptomics was built ...

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