Fen Bilimleri Enstitüsü: Recent submissions

  • Disease gene identification via linkage analysis and exome sequencing 
    Güven, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Understanding the genetic basis of hereditary diseases elucidates the molecular mechanisms underlying disease manifestations and uncovers valuable information about gene function. Consanguineous families are very useful ...
  • Genetic diversity of almonds (Prunus dulcis) of Datça 
    Kaptan, Damla. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Anatolia’s agricultural biodiversity, which has evolved with the contributions of many different cultures over thousands of years, is today being rapidly eroded as a result of climate change, population growth, globalization ...
  • Identification and in vivo analysis of putative Wnt target genes with effective roles in cancer 
    Even, İpek. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    One of the most common driving forces in hepatocellular carcinoma (HCC) is the aberrant activation of the Wnt/β-catenin signaling due to the accumulation of mutant β-catenin in the cell. Our group previously detected several ...
  • Detection of DNA duplications in charcot-marie-tooth type 1 (CMT1) patients by DNA analysis 
    Bissar-Tadmouri, Nisrine. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1997., 1997.)
    Charcot-Marie-Tooth neuropathy (CMT), also known as Hereditary Motor and Sensory Neuropathy (HMSN), is a heterogeneous group of inherited diseases of peripheral nerves. It is estimated that 112500 persons have a form of ...
  • Schizophrenia: another emphasis of ERBB4 and NRG1 impact on disease development 
    Ağım, Zeynep Sena. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Schizophrenia, which is one of the most commonly reported illnesses among all psychiatric disorders, is defined as a complex disease; this implicates that it does not show a simple Mendelian pattern of inheritance. The ...
  • Two faces of ASC : central innate immunity adaptor ASC turns into melanoma ally and novel mechanism demistifying dsRNA induced NLRP3 inflammasome activation through Bax/Bak mediated cell death 
    Özkurede, Varol Ulaş. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    In this study, by specifically focusing on the role of ASC in melanoma and NLRP3 activation in response to double stranded RNA, we try to provide answers to more general but basic questions: “How and why would cancer cells ...
  • Virulence and genetic diversity of Colletotrichum Lindemuthianum isolates collected from common bean varieties of Turkey 
    Küçükyan Canseven, Serli. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    The common bean (Phaseolus vulgaris L.) is the most widely distributed and consumed legume species of the genus Phaseolus. As one of the major producer in the world, common bean production is highly dominated by the Black ...
  • Possible interactors of alsin and effects of its expression on four motor neuron disease-related proteins 
    Çobanoğlu, Gönenç. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Motor neuron disorders, characterized by selective motor neuron degeneration, consist of a large group of diseases with overlapping genes and common pathological mechanisms. Mutations in ALS2, associated with three types ...
  • Co-expression of odorant receptor genes in zebrafish 
    Atasoy, Arif Murat. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Olfactory receptors constitute the largest G-Protein-Coupled Receptor family in humans and in other vertebrates. Olfactory receptor genes are expressed in the olfactory sensory neurons in the olfactory epithelia and are ...
  • Role of IroC in the fly olfactory system 
    Talay, Mustafa. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Sensory neurons, such as the visual and olfactory neurons, tend to express only one sensory receptor per neuron in order to prevent sensory overlap and then send their axons to particular target regions in the brain to ...
  • ERK, AKT and PKA as regulatory kinases of SIK2 in FGF signaling in muller cells 
    Ejder, Funda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    FGF2 dependent retinal Müller cell proliferation is elicited mainly via activation of Ras/MAPK pathway. Phosphorylation/dephosphorylation of intermediates is one of the key mechanisms for the transient and rapid regulation ...
  • SIK2 involvement in dowregulation of FGF signaling through Gab1 and Raf1 
    Sert, Yeliz Yılmaz. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Proliferative response of Müller cells to FGF2 is propagated via Ras/MAPK pathway, and involves rapid and transient ERK1/2 activation. Results from our laboratory implicate SIK2 in the regulation of FGF2 signaling via ...
  • Cloning and characterization of novel nod like receptors as cytoplasmic immune sensors 
    Gültekin, Yetiş. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    NOD like receptors recognize infection and cellular damage. They are characterized by an N terminal protein interaction domain, central oligomerization domain, termed nucleotide binding domain and leucine rich repeat domain ...
  • Genetically accurate models of SOD1-based ALS in Drosophila melanogaster 
    Deniz, Pınar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    ALS is a late onset, rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Generally, 5-10% of ALS patients have a family history (fALS), ...
  • The impact of mutant alsin protein on motor neuron models and the effects of alsin gene knock-down on motor protein genes 
    Lahut, Suna. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Alsin is a ubiquitously expressed protein with the highest levels in the central nervous system. Mutations in the alsin gene have been associated with several juvenile onset recessive motor neuron diseases. Nine out of 12 ...
  • The molecular basis of alpha-thalassemia in Turkey: |establishment and application of PCR-based methods 
    Taştan, A. Özlem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1996., 1996.)
    As in many other Mediterranean countries, hemoglobinopathies, especially thalassemias pose a major health concern in the Turkish population. Alpha-thalassemias, which may be the most common genetic disorders of human being, ...
  • Linkage analysis and candidate gene approach in three disorders 
    Yıldırım, Yeşerin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    Genetically inherited diseases are powerful resources for defining new gene functions. Genetic linkage analysis is the tool used for identifying the locus/loci harboring the gene(s) responsible for a particular disease. ...
  • Exclusion of autosomal recessive hereditary spastic paraplegia loci in Turkish families 
    Özeş, Burçak. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Hereditary spastic paraplegias (HSPs), also known as Strümpell-Lorrain disease, describe a heterogeneous group of genetic neurodegenerative disorders. The main feature of the disease is progressive spasticity in the lower ...
  • Importance of ASC expression for melanoma tumorigenesis in vivo and a role for inflammasome activation in apoptosis induction 
    Çifdalöz, Metehan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    ASC is an adaptor protein which is capable of binding to numerous partners due to its two oligomerization domains, PYRIN and CARD. Its involvement in the inflammasome complex as an essential adaptor, in the regulation of ...
  • Characterization of genes involved in photoreceptor differentiation 
    Öztürk, Arzu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    The one receptor - one neuron rule is a common phenomenon observed in sensory organs. In the Drosophila eye, each photoreceptor expresses one of six different rhodopsin genes. The expression patterns of inner photoreceptors ...

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