Fen Bilimleri Enstitüsü: Recent submissions

  • Identification of C17ORF45 protein and the effects of its snornas on cell cycle 
    Kapıkıran, Vahap. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The Wnt / β-catenin signaling has many important roles in cellular responses and dysregulation of this pathway are linked to tumor formation. Priorly, SAGE and microarray analyses were performed in our laboratory in order ...
  • Genetic analyses in Seckel syndrome and azoospermia 
    Korur, Serdar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2004., 2004.)
    The autosomal recessive genetic disorders Seckel syndrome and azoospermia were studied. In Seckel syndrome, the two known loci were tested for linkage in 15 Seckel families. In addition, four ATR interacting and fifteen ...
  • The functional role of ASP50 in protein synthesis elongation factor Tu 
    Baş, Levent. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu is an essential enzyme responsible for delivering aminoacyltRNA's to ribosomal A-site during protein synthesis. In its active GTP-bound state, it forms an EF-Tu · GTP · aminoacyl-tRNA ternary complex ...
  • Development and molecular analysis of CMT4B1 drosophila model 
    Kılınç, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. Among about 40 genes associated with the disease, MTMR2 loss-of-function mutations are classified as CMT4B1 subtype. ...
  • Evaluation of exome sequencing data & mutation screening in GDAP1, GJB1, MPZ, NDRG1 and PMP22 genes in Turkish CMT patients 
    Sıvacı, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease which is an inherited peripheral neuropathy is an excellent candidate to be analyzed by exome sequencing because of its locus heterogeneity and low prevalence. Protein-coding regions, ‘the ...
  • Characterization of a novel R7-specific gene in the drosophila visual system 
    Kaçmaz, Güner. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The proper functioning of the nervous system depends on the correct specification of many different cell types and the establishment of proper connections between neurons during development. The visual system of Drosophila ...
  • Elucidating the role of foxo transcription factors on lithium induced growth arrest in hepatocellular carcinoma cells 
    Şekerci, Esra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Lithium is one of the most effective drugs for the treatment of bipolar disorder for years. Many studies have shown that lithium has neuroprotective effect and has acapacity to inhibit cell proliferation. Specifically, it ...
  • Structural aspects of ASC speck formation and its potential novel functions 
    Sahillioğlu, Ali Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
  • The genetics of sporadic ALS: the first Turkish GWAS and novel SNP and CNV association 
    Uyan, Özgün. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Selective degeneration of both lower and upper motor neurons located in the brain cortex, brainstem and ventral horn of the spinal cord result in amyotrophic lateral sclerosis (ALS). ALS is the most frequent late-onset ...
  • Genetic factors contributing to ALS in Turkey: ATXN2 polyQ repeat expansions and SNP/CNV associations 
    Ömür, Özgül. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    ALS is the most frequent motor neuron disorder and so far no cure has been developed for this devastating disease. ALS is characterized by the selective loss of both the upper motor neurons of the motor cortex and the lower ...
  • Genetically accurate models of SOD1-based ALS in drosophila: validation and characterization 
    İskender, Ceren. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    SOD1 has been a unique target of ALS research as the first identified gene of the disease; since 20 years, SOD1 has not been related to any other disease unlike other ALScausing genes. There are more than 160 mutations ...
  • The role of theodorant receptor coding sequence in the regulation of odorant receptor transgene expression in Zebrafish 
    Taştekin, İbrahim. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Odorant receptors constitute the largest gene family in rodents and probably in all vertebrates. In addition to detecting the odorant molecules in the outside world, odorant receptorrs are responsible for some critical ...
  • Expression of aFGF and FGF9 in the developing rat retina 
    Çayırlıoğlu, Pelin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Sciences and Engineering, 1995., 1997.)
    aFGF, an FGF gene family member, has been postulated to be important in the physiology and development of vertebrate retina. The distribution and relative levels of aFGF mRNA in the external photoreceptors layer, and in ...
  • Involvement of SIK2 in FGF2 signal regulation via RAF-1 and generation of mutants for identification of phosphorylation sites on SIK2 by ERK 
    Akay, Özden. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Müller cell proliferation is induced by FGF2 signaling via Ras/MAPK pathway through rapid and transient ERK1/2 activation. Salt inducible kinase 2 (SIK2), a serine/threonine kinase, is a novel regulator in this context. ...
  • A privileged hunter: role of NLRP7 in immune privilege 
    Demiröz, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    NOD-like receptors (NLRs) are a family of cytoplasmic receptors with members regulating apoptosis and inflammation. NLRP7 is a novel PYRIN domain containing NLR family member and its functions are still under investigation. ...
  • Identification of the role of a novel cell adhesion molecule, unzipped, in mediating neuron-glia interactions in drosophila 
    Zülbahar, Selen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The intricate but still precise pattern of brain circuitry is unquestionably the most complex feature of both vertebrates and invertebrates. How that complex circuitry develops has been the subject of intense study for ...
  • A FLY's view of salt inducible kinases: a synergistic tumorigenesis model 
    Sayın, Sercan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The recent explosion of data generated by high-throughput assays on cancer necessitated reliable and fast in vivo models for evaluation new catalogue of candidate genes as tumor suppressors or proto-oncogenes and their ...
  • Mutation, exome sequencing and linkage analyses in Turkish CMT families 
    Erdoğan, Alperen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Charcot-Marie-Tooth disease (CMT) also known as hereditary motor and sensory neuropathy (HMSN) is the most frequent inherited neuropathy. The patients with CMT generally have distal muscle weakness and atrophy in the ...
  • Identification and docking analysis of allatostatin receptor in Carausius morosus 
    Duan, Burçin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Allatostatin receptors (AlstRs) with their ligands (ASTs) play role in insect development, by inhibiting the production of Juvenile hormone. This thesis project uses the advances in structure-based studies and single-molecule ...
  • Transgenic analysis of the Zebrafish OR101-1 gene promoter 
    Söğünmez, Nuray. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The repertoire of olfactory receptors constitutes the largest gene families in humans and in other vertebrates. Typically, olfactory sensory neurons only express a single member of the large genomic repertoire and only one ...

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