Fen Bilimleri Enstitüsü: Recent submissions

  • Parkinson's disease in Turkish patients: molecular defects in familial and isolated cases 
    Pirkevi, Caroline Selma. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Parkinson's disease (PD) is worldwide the second most common neurodegenerative disorder after Alzheimer's disease. Recently, several genes have been shown to result in PD phenotype. Mutations in these genes may lead to ...
  • Translational regulation of Kidney Injury Molecule-1 MRNA: presence of an internal ribosomal entry site 
    Banaz, Nehir. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Kidney Injury Molecule-1 (KIM-1) is a type I transmembrane glycoprotein that is highly upregulated on regenerating dedi erentiated renal proximal tubular epithelial cells as a consequence of toxic or ischemic injury. KIM-1 ...
  • The role of unzipped axon guidance and targeting in the olfactory system of drosophila melanogaster 
    Mika, Kaan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    The olfactory system of Drosophila is a great model to investigate neural wiring complexity. The fly has two sensory appendages named as antenna and maxillary palp. Hair-like structures called as sensilla cover the appendages ...
  • Functional analysis of a splice site mutation in BABRG2 gene and its effect on GABAA receptor 
    Kaplan, Öyküm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Epilepsy is a group of diseases produced by non-controlled discharge of neurons affecting more than 2% of the population and some forms include genetic determinants. The principal group of inherited epilepsy is Genetic ...
  • Functional study of certain genes selected from SSH library of common bean under salinity stress 
    Canher, Balkan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Considering that one third of Earth’s arable lands are affected by soil salinity, understanding how plants respond to salinity stress and creation of stress tolerant crops is of outmost importance. Phaseolus vulgaris (common ...
  • Involvement of autophagy in ochratoxin-a (OTA) -mediated toxicity in HK-2 cell line 
    Kahraman, Hilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Ochratoxin A (OTA) is a secondary metabolite produced by fungi and found in a variety of food and feed. It is classi ed as a possible human carcinogen and immense amount of work has revealed to its nephrotoxic and carcinogenic ...
  • Characterization of Interferon Regulatory Factor 4 (IRF4) target genes in melanoma cell lines 
    Yılmaz, Erdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    IRF4 is a critical transcription factor in the development and function of immune cells, and additionally, it is deregulated in certain myeloid and lymphoid malignancies. Un-til recently, IRF4 expression was thought to be ...
  • Mammalian enabled (MENA): a possible regulator of yap oncoprotein 
    Karaman, Ruçhan (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Mammalian Enabled (Mena) induces unbranched actin polymerization and it acts as an antagonist for actin capping proteins in the cell. As an actin related protein, Mena has an important role on both tumor initiation and ...
  • Validation of the OR103-1/5 intergenic sequence as a molecular tool to promote bi-cistronic translation in zebrafish 
    Uzel, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Sensory neuron in the olfactory system, typically expresses only a single olfactory receptor (OR) gene from a large and diverse genomic repertoire. In zebrafish, a violation of this ‘one neuron – one receptor rule’ has ...
  • Identification of novel genes involved in planar cell polarity establishment in the Drosophila eye 
    Koldere, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    In multicellular organisms proper functioning of tissues requires precise patterning of cells, which is acquired by apical-basal and planar cell polarization. To establish planar cell polarity (PCP), cells have to organize ...
  • Characterization and regulation of human Kim-1 gene promoter the role of activator protein 1 (AP1) transchiption factor 
    Bergin, Tijen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Kidney Injury Molecule-1 (KIM-1) is an immunoglobulin superfamily cell surface protein highly upregulated on the surface of dedifferentiated renal proximal tubule epithelial cells regenerating after toxic or ischemic injury. ...
  • Disease gene search via linkage mapping and exome sequencing 
    Köroğlu Altok, Çiğdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of disease genes has a key importance in understanding the molecular mechanisms of disease pathogenesis as well as in expanding our knowledge on gene function. Linkage mapping is a powerful method to identify ...
  • Cloning, expression and purfication of the recombinant DNA polymerase I from the hyperthermophilic bacteria geobacillus anatolicus 
    Çağlayan, Melike. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2005., 2005.)
    The DNA polymerase I gene of a recently described Geobacillus species, Geobacillus anatolicus from a terrestrial hydrothermal vent has been cloned and expressed in Escherichia coli. Evolutionarily conserved regions of DNA ...
  • Linkage and exome sequence analyses to identify disease genes 
    Ayhan, Özgecan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of the genetic basis of a hereditary disease provides important information about the molecular mechanism of the disease and the function of the gene and could contribute to the development of therapeutic ...
  • Development of a drosophila CMT4A model using imago approach 
    Yıldırım, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. So far, approximately 50 genes and loci have been associated with CMT. Mutations in ganglioside-induced differentiation-associated protein ...
  • Identification of interaction partners of unzipped, a novel cell adhesion molecule 
    Akgün, Gamze. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The brain is unquestionably the most sophisticated organ in bodies of many organisms. Establishment of this complex architecture depends on the ability of axons to find their proper targets. On their way to their synaptic ...
  • SIK3 involvement in FGF2 signaling in Müller cells 
    Koca, Yıldız. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    FGF2 stimulation of Millier cells regulates several processes including cell proliferation and survival by triggering the activation RaslMAPK and PI3K1 Akt pathways. Data from our lab indicate that serine/threonine kinase ...
  • Development of a drosophila CMT model via overexpression and knocking-in of GDAP1 gene 
    Akyüz, Hüseyin Kaya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is one of the most common inherited disorders of the nervous system. Known also as hereditary motor and sensory neuropathy, this disease is characterized by distal sensory loss, muscle ...
  • Characterization of IRF4 dependency in melanoma cell lines 
    Ayhan, Mustafa Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Interferon Regulatory Factor 4 (IRF4, also known as MUM1, LSIRF, NFEM5, and ICSAT) is a transcription factor with important regulatory roles on B-cell matura-tion and differentiation. Although the first identification of ...
  • Studying the role of phosphorylation of bacterial protein synthesis elongation factor Tu 
    Kaplan, Uğur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu (EF-Tu) plays a crucial role of carrying aminoacylated-tRNA molecules to the ribosome during the elongation phase of protein synthesis. Being a guanine nucleotide binding protein, EF-Tu is inactive ...