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Structural and mechanical characterization of Calcium Phosphate Cements (CTCs) with different powder-liquid ratios

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dc.contributor Graduate Program in Biomedical Engineering.
dc.contributor.advisor Ege, Duygu.
dc.contributor.author Yetiş, Şule
dc.date.accessioned 2023-03-16T13:13:22Z
dc.date.available 2023-03-16T13:13:22Z
dc.date.issued 2019.
dc.identifier.other BM 2019 Y47
dc.identifier.uri http://digitalarchive.boun.edu.tr/handle/123456789/18916
dc.description.abstract Calcium phosphate cements (CPCs) are encouraging osteoconductive bone substitutes for bone grafting. In this study, new bone cements were prepared by mixing powders of tetra calcium phosphate (TTCP), dicalcium phosphate dihydrate (DCPD) andcalciumsulfatedehydrate(CSD)topolymericsolutionincludingCMCandgelatin. Samples with different powder-to-liquid ratio (62.5, 65, 67.5, and 70%) were fabricated and characterized. Scanning Electron Microscopy (SEM), mechanical testing, Fourier Transform Infrared Spectroscopy (FTIR), Thermo-gravimetric Analysis (TGA), and X-raydiffraction(XRD)Analysiswereperformedtocharacterizemechanicalandstructural properties of synthesized composites. FTIR results confirmed the electrostatic interaction between COO− groups in carboxymethyl cellulose (CMC) and Ca2+ ions released from CPCs. Hydroxyapatite (HA) formation was observed and assessed via XRD and SEM analysis on the samples incubated in phosphate buffer saline (PBS) solution for 28 days. Furthermore, the compressive strength values of composites were calculated as 1.63±0.046, 1.53±0.053, 0.91±0.015 and 1.28±0.072 MPa for P62.5, P65, P67.5, and P70, respectively. The overall results show that composite with 65% powder ratio may be appropriate for applications in the field of bone tissue engineering considering that it has the most proper mixture of the powder and liquid phase, high HA formation and sufficient mechanical properties for bone regeneration.|Keywords : Calcium phosphate, carboxymethyl cellulose, composite, mechanic, bone.
dc.format.extent 30 cm.
dc.publisher Thesis (M.S.)-Bogazici University. Institute of Biomedical Engineering, 2019.
dc.subject.lcsh Calcium phosphate -- Biotechnology.
dc.subject.lcsh Biomedical materials.
dc.subject.lcsh Bone.
dc.title Structural and mechanical characterization of Calcium Phosphate Cements (CTCs) with different powder-liquid ratios
dc.format.pages xii, 33 leaves ;


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