Computational analysis of AcDS in CA1 and CA3 pyramidal neurons with axon carying dendrites

Abstract

Pyramidal neurons are the most abundant excitatory cell type in cortex and hippocampus. The canonical topology of these glutamatergic neurons consists of a pyramidal-shaped soma, an apical dendrite extending vertically between layers, basal dendrites extending horizontally in the same layer and an axon extending from soma. However, the recent studies show that some hippocampal pyramidal neurons on Cornu Ammonis (CA) of healthy mammalian brain possess an axon that is placed on the basal dendrite in many instances. This phenomenon is observed in 50% in CA1 and 30% in CA3 and in these cell types the stimulus is privileged on the AcD. The e ect on information processes is thought to be in hippocampal trisynaptic circuits are not clari ed yet. Neither the reason behind this di erentiation nor the circumstances under which this phenomenon occurs is discovered. In this study, CA1 and CA3 pyramidal neurons with AcDs and with regular neurites are modeled on NEURON simulation platform for understanding the function of axon-carrying dendrites. The results showed a signi cant di erence in the potential conservation in AcD cells compared to nonAcD cells and privilege on the AcD branches which can enhance the plasticity and LTP processes.|Keywords : AcDs, Pyramidal Neurons, Hippocampus, CA1, CA3.