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Characterization of adipokinetic hormone receptor in stick insect, Carausius Morosus

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dc.contributor Graduate Program in Molecular Biology and Genetics.
dc.contributor.advisor İyison, Necla Birgül.
dc.contributor.author Sınmaz, Merve Gizem.
dc.date.accessioned 2023-03-16T11:25:43Z
dc.date.available 2023-03-16T11:25:43Z
dc.date.issued 2018.
dc.identifier.other BIO 2018 S56
dc.identifier.uri http://digitalarchive.boun.edu.tr/handle/123456789/15378
dc.description.abstract Adipokinetic hormone (AKH) is an insect neuropeptide and known as gonadotropinreleasing hormone, which is orthologue to humans. It is released from corpora cardiaca and acts generally on fat body for energy mobilization. It is also involved in several different physiological functions such as increasing blood hemolymph trehalose levels, heart beat frequency, and protein synthesis. Furthermore it functions in inhibiting fatty acid and RNA synthesis in different insect species. It activates its corresponding G-Protein Coupled Receptors (GPCR), which are Adipokinetic Hormone receptors (AKHR). Many AKHRs were studied so far, but not in stick insect, Carausius morosus. Utilizing transcriptome data of stick insect, its AKHR (CamAKHR) and AKH (CamAKH) were identified. It was aimed to characterize AKHR of stick insect by homology modeling, docking analysis and molecular dynamics within this project contributing to the production of a novel neuropeptide-based next-generation pesticide. At the end, thirteen important residues mostly located in transmembrane 6, transmembrane 7 and extracellular loop 2 regions of CamAKHR model were observed contributing to ligand binding in CamAKHR- CamAKH complex. Six of them were found as the most conserved residues in different insect species, therefore proposed binding pocket includes these Glu246, Arg269, Tyr423, Tyr430, Lys446 and Phe449 residues corresponding to TM2, TM3, TM6 and TM7 of CamAKHR.
dc.format.extent 30 cm.
dc.publisher Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018.
dc.subject.lcsh Carausius morosus.
dc.title Characterization of adipokinetic hormone receptor in stick insect, Carausius Morosus
dc.format.pages xv, 61 leaves ;


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