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Polymer - dendron based micelles as drug delivery systems

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dc.contributor Graduate Program in Chemistry.
dc.contributor.advisor Sanyal, Rana.
dc.contributor.author Bilgen, Nuray.
dc.date.accessioned 2023-03-16T11:01:49Z
dc.date.available 2023-03-16T11:01:49Z
dc.date.issued 2012.
dc.identifier.other CHEM 2012 B56
dc.identifier.uri http://digitalarchive.boun.edu.tr/handle/123456789/14494
dc.description.abstract Polymeric micelles are remarkable nominees for drug delivery systems due to their excellent biocompatibility also they provide high loading capacity to hydrophobic inner core and increase drug solubility. In water, micelles can be formed via self-assembly and this micelle formation is connected to the solubility difference of the hydrophilic and hydrophobic part. Hydrophobic parts form the inner core of the micelle and hydrophilic part which surrounds the core form the sphere of micelle. In our study, polymer-dendron conjugates are prepared via Huisgen type „click‟ reaction using polyester dendrons and PEG. Biocompatible PEG is used as the polymer to provide water solubility to hydrophobic drug molecules. The conjugation of Dendron to PEG followed by functionalization of the dendron periphery with hydrophobic moiety. This system provided the hydrophilic-hydrophobic balance necessary to form the polymeric micelles in aqueous media. Dendron surface was further decorated with drug molecules to yield the micellar drug delivery system.
dc.format.extent 30 cm.
dc.publisher Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012.
dc.relation Includes appendices.
dc.relation Includes appendices.
dc.subject.lcsh Surface acting agents.
dc.subject.lcsh Micelles.
dc.subject.lcsh Neutrons -- Scattering.
dc.title Polymer - dendron based micelles as drug delivery systems
dc.format.pages xv, 72 leaves ;


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