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dc.contributor Graduate Program in Chemistry.
dc.contributor.advisor Sanyal, Rana.
dc.contributor.author Çıtak, Duygu.
dc.date.accessioned 2023-03-16T11:01:34Z
dc.date.available 2023-03-16T11:01:34Z
dc.date.issued 2010.
dc.identifier.other CHEM 2010 C58
dc.identifier.uri http://digitalarchive.boun.edu.tr/handle/123456789/14466
dc.description.abstract Angiogenesis can be explained as the growth of new blood vessels from pre-existing vasculature. It has an important and vital role in growth and development, as well as in wound healing. Anti-angiogenic substances suppress the growth of new blood vessels so prevent nutrients and oxygen needed for the growing of tumor cells. It is proposed that tumor angiogenesis could serve as a potential target for anticancer therapy. Combretastatin (CA-4) is an anti-angiogenesis agent that inhibits the tubulin polymerization. CA-4 exhibits anti-tumor effects through the well-organized therapeutic mechanism of tumor blood supply disabling. By affecting selectively and blocking tumor vasculature, CA-4 reduces the blood supply needed for tumor growth and survival. As a result of oxygen poverty and build-up of tumor metabolic by-products causes the death of the cancer cells within the central core of the tumor. In this thesis, covalent modification of CA-4 has been investigated. Variety of CA-4 analogs which involved blocking the free alcohol group has been synthesized.
dc.format.extent 30cm.
dc.publisher Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010.
dc.relation Includes appendices.
dc.relation Includes appendices.
dc.subject.lcsh Neovascularization.
dc.title Anti-angiogenesis chemotherapy agents
dc.format.pages xiii, 57 leaves;


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