dc.contributor |
Graduate Program in Chemistry. |
|
dc.contributor.advisor |
Sanyal, Rana. |
|
dc.contributor.author |
Çıtak, Duygu. |
|
dc.date.accessioned |
2023-03-16T11:01:34Z |
|
dc.date.available |
2023-03-16T11:01:34Z |
|
dc.date.issued |
2010. |
|
dc.identifier.other |
CHEM 2010 C58 |
|
dc.identifier.uri |
http://digitalarchive.boun.edu.tr/handle/123456789/14466 |
|
dc.description.abstract |
Angiogenesis can be explained as the growth of new blood vessels from pre-existing vasculature. It has an important and vital role in growth and development, as well as in wound healing. Anti-angiogenic substances suppress the growth of new blood vessels so prevent nutrients and oxygen needed for the growing of tumor cells. It is proposed that tumor angiogenesis could serve as a potential target for anticancer therapy. Combretastatin (CA-4) is an anti-angiogenesis agent that inhibits the tubulin polymerization. CA-4 exhibits anti-tumor effects through the well-organized therapeutic mechanism of tumor blood supply disabling. By affecting selectively and blocking tumor vasculature, CA-4 reduces the blood supply needed for tumor growth and survival. As a result of oxygen poverty and build-up of tumor metabolic by-products causes the death of the cancer cells within the central core of the tumor. In this thesis, covalent modification of CA-4 has been investigated. Variety of CA-4 analogs which involved blocking the free alcohol group has been synthesized. |
|
dc.format.extent |
30cm. |
|
dc.publisher |
Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010. |
|
dc.relation |
Includes appendices. |
|
dc.relation |
Includes appendices. |
|
dc.subject.lcsh |
Neovascularization. |
|
dc.title |
Anti-angiogenesis chemotherapy agents |
|
dc.format.pages |
xiii, 57 leaves; |
|