Arşiv ve Dokümantasyon Merkezi
Dijital Arşivi

Photoacoustic signal detection via atomic force microscopy cantilevers

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dc.contributor Ph.D. Program in Physics.
dc.contributor.advisor Ünlü, Mehmet Burçin.
dc.contributor.author Demirkıran, Aytaç.
dc.date.accessioned 2023-03-16T10:46:20Z
dc.date.available 2023-03-16T10:46:20Z
dc.date.issued 2018.
dc.identifier.other PHYS 2018 D46 PhD
dc.identifier.uri http://digitalarchive.boun.edu.tr/handle/123456789/13783
dc.description.abstract In this thesis, we first present a custom-designed photoacoustic microscopy system (PAM) which includes two separate excitation lasers. One of these tools is a novel fiber-based laser system developed particularly for multiwavelength optical resolution photoacoustic microscopy. The fiber laser has adjustable properties including pulse duration (5-10 ns), pulse energy (up to 10 µJ) and repetition frequency (up to 1 MHz) independently from each other. The whole laser system covers a broad spectral region from 450 to 1100 nm by its supercontinuum output and also can emit wavelengths of 532, 355, and 266 nm from its harmonic generation unit. The other laser source in the PAM system is a commercial tunable optical parametric oscillator (OPO) laser. The lateral resolution of the PAM system is approximately 2 µm. We present various biological (horse hair, human red blood cells, Skmel-28 cancer cells) and non-biological (resolution test target, India inks, cadmium telluride quantum dots) photoacoustic images obtained with our PAM system. In addition, we present a custom-developed atomic force microscopy (AFM) head to detect both acoustic and photoacoustic sig nals using microcantilevers as the pressure sensor. Here, as a preliminary study for the AFM-head system, we analyzed microcantilevers to investigate their responses to pulsed-laser-induced photoacoustic waves. The results indicate that microcantilevers can be used as photoacoustic detection tools by presenting steady-state oscillations when the repetition frequency of the excitation laser matches to the resonant frequency of the cantilever. Finally, for the proof-of-concept studies, we utilized the AFM-head system to detect acoustic waves at various frequencies arising from a personal headset, and also photoacoustic waves from a black ink phantom illuminated by the OPO laser. The AFM-head system is compact, portable, and very sensitive to external forces.
dc.format.extent 30 cm.
dc.publisher Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018.
dc.subject.lcsh Microscopy.
dc.subject.lcsh Optoacoustic spectroscopy .
dc.subject.lcsh Imaging systems in medicine.
dc.title Photoacoustic signal detection via atomic force microscopy cantilevers
dc.format.pages xxi, 108 leaves ;


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