M.S. Theses: Recent submissions

  • Canher, Balkan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Considering that one third of Earth’s arable lands are affected by soil salinity, understanding how plants respond to salinity stress and creation of stress tolerant crops is of outmost importance. Phaseolus vulgaris (common ...
  • Kahraman, Hilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Ochratoxin A (OTA) is a secondary metabolite produced by fungi and found in a variety of food and feed. It is classi ed as a possible human carcinogen and immense amount of work has revealed to its nephrotoxic and carcinogenic ...
  • Yılmaz, Erdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    IRF4 is a critical transcription factor in the development and function of immune cells, and additionally, it is deregulated in certain myeloid and lymphoid malignancies. Un-til recently, IRF4 expression was thought to be ...
  • Karaman, Ruçhan (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Mammalian Enabled (Mena) induces unbranched actin polymerization and it acts as an antagonist for actin capping proteins in the cell. As an actin related protein, Mena has an important role on both tumor initiation and ...
  • Uzel, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Sensory neuron in the olfactory system, typically expresses only a single olfactory receptor (OR) gene from a large and diverse genomic repertoire. In zebrafish, a violation of this ‘one neuron – one receptor rule’ has ...
  • Koldere, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    In multicellular organisms proper functioning of tissues requires precise patterning of cells, which is acquired by apical-basal and planar cell polarization. To establish planar cell polarity (PCP), cells have to organize ...
  • Bergin, Tijen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Kidney Injury Molecule-1 (KIM-1) is an immunoglobulin superfamily cell surface protein highly upregulated on the surface of dedifferentiated renal proximal tubule epithelial cells regenerating after toxic or ischemic injury. ...
  • Köroğlu Altok, Çiğdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of disease genes has a key importance in understanding the molecular mechanisms of disease pathogenesis as well as in expanding our knowledge on gene function. Linkage mapping is a powerful method to identify ...
  • Çağlayan, Melike. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2005., 2005.)
    The DNA polymerase I gene of a recently described Geobacillus species, Geobacillus anatolicus from a terrestrial hydrothermal vent has been cloned and expressed in Escherichia coli. Evolutionarily conserved regions of DNA ...
  • Ayhan, Özgecan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of the genetic basis of a hereditary disease provides important information about the molecular mechanism of the disease and the function of the gene and could contribute to the development of therapeutic ...
  • Yıldırım, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. So far, approximately 50 genes and loci have been associated with CMT. Mutations in ganglioside-induced differentiation-associated protein ...
  • Akgün, Gamze. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The brain is unquestionably the most sophisticated organ in bodies of many organisms. Establishment of this complex architecture depends on the ability of axons to find their proper targets. On their way to their synaptic ...
  • Koca, Yıldız. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    FGF2 stimulation of Millier cells regulates several processes including cell proliferation and survival by triggering the activation RaslMAPK and PI3K1 Akt pathways. Data from our lab indicate that serine/threonine kinase ...
  • Akyüz, Hüseyin Kaya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is one of the most common inherited disorders of the nervous system. Known also as hereditary motor and sensory neuropathy, this disease is characterized by distal sensory loss, muscle ...
  • Ayhan, Mustafa Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Interferon Regulatory Factor 4 (IRF4, also known as MUM1, LSIRF, NFEM5, and ICSAT) is a transcription factor with important regulatory roles on B-cell matura-tion and differentiation. Although the first identification of ...
  • Kaplan, Uğur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu (EF-Tu) plays a crucial role of carrying aminoacylated-tRNA molecules to the ribosome during the elongation phase of protein synthesis. Being a guanine nucleotide binding protein, EF-Tu is inactive ...
  • Kapıkıran, Vahap. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The Wnt / β-catenin signaling has many important roles in cellular responses and dysregulation of this pathway are linked to tumor formation. Priorly, SAGE and microarray analyses were performed in our laboratory in order ...
  • Korur, Serdar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2004., 2004.)
    The autosomal recessive genetic disorders Seckel syndrome and azoospermia were studied. In Seckel syndrome, the two known loci were tested for linkage in 15 Seckel families. In addition, four ATR interacting and fifteen ...
  • Baş, Levent. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu is an essential enzyme responsible for delivering aminoacyltRNA's to ribosomal A-site during protein synthesis. In its active GTP-bound state, it forms an EF-Tu · GTP · aminoacyl-tRNA ternary complex ...
  • Kılınç, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. Among about 40 genes associated with the disease, MTMR2 loss-of-function mutations are classified as CMT4B1 subtype. ...

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