Browsing M.S. Theses by Title

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  • Linkage analysis and candidate gene approach in three disorders 
    Yıldırım, Yeşerin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    Genetically inherited diseases are powerful resources for defining new gene functions. Genetic linkage analysis is the tool used for identifying the locus/loci harboring the gene(s) responsible for a particular disease. ...
  • Linkage and exome sequence analyses to identify disease genes 
    Ayhan, Özgecan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of the genetic basis of a hereditary disease provides important information about the molecular mechanism of the disease and the function of the gene and could contribute to the development of therapeutic ...
  • Locus and gene search in three disorders 
    Hazan, Renin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Identification of genetic defects associated with hereditary diseases is important in understanding cellular mechanisms and molecular etiology of diseases, developing diagnostic tests and novel therapeutic techniques. In ...
  • Mammalian enabled (MENA): a possible regulator of yap oncoprotein 
    Karaman, Ruçhan (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Mammalian Enabled (Mena) induces unbranched actin polymerization and it acts as an antagonist for actin capping proteins in the cell. As an actin related protein, Mena has an important role on both tumor initiation and ...
  • MENA, BR13 and HSF2 as novel transcriptional targets of the Wnt/β-catenin pathway 
    Najafov, Ayaz. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Wnt/β-catenin signaling pathway plays important roles in embryonic development and carcinogenesis, which makes the pathway and its targets important subjects in developmental biology and cancer research fields. In its ...
  • Molecular analysis of Alzheimer's disease and frontotemporal dementia: anovel mutation in the presenilin 1 gene of a Turkish patient with early onset familial Alzheimer's disease 
    Hocaoğlu, Fatma Sinem. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Alzheimer’s Disease (AD) and Frontotemporal Dementia (FTD) are the most common causes of dementia and death in developed countries. AD is clinically characterized by a progressive decline in cognitive functions. In most ...
  • Molecular analysis of hemoglobinopathies and construction of a database; identification of a novel IVS-II-2 (T-A) mutation 
    Latif, Ayşe. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Hemoglobinopathies, inherited disorders of the hemoglobin (Hb) molecule, display great molecular and phenotypic diversity. Beta-thalassemia major is considered as the most severe form of hemoglobinopathies and requires ...
  • Molecular genetic analysis of benign epilepsy syndromes 
    Kayserili, Melek Aslı. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Generalized Epilepsy with Febrile Seizures Plus (GEFS+) and Benign Familial Infantile Seizures (BFIS) are some of the benign epilepsy syndromes. GEFS+ is a collection of phenotypes that show febrile seizures beyond the age ...
  • Molecular genetic analysis of Lafora Disease and Dravet's Syndrome 
    Salar, Seda. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Lafora Disease (LD), a type of Progressive Myoclonus Epilepsy (PME) and Dravet’s Syndrome (DS), the most severe form in Generalized Epilepsy with Febrile Seizure Plus (GEFS+) spectrum, are debilitating examples of epilepsy ...
  • Mutation, exome sequencing and linkage analyses in Turkish CMT families 
    Erdoğan, Alperen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Charcot-Marie-Tooth disease (CMT) also known as hereditary motor and sensory neuropathy (HMSN) is the most frequent inherited neuropathy. The patients with CMT generally have distal muscle weakness and atrophy in the ...
  • Mutational analysis of Factor XI and Von Willebrand Factor genes by high resolution melting analysis and direct DNA sequencing 
    Usluer, Sunay. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Continuous flow of blood is essential for life and its maintenance is an important task for the body. Hemostasis is the balance between the coagulants, factors that promote blood clot formation and anti-coagulants, factors ...
  • Mutational analysis of the ARX gene and whole exome sequencing in epileptic encephalopathy patients 
    Özünlü, Hande. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    The term epileptic encephalopathy (EE) is used to describe epileptic syndromes with generally early onset, within the first year of life, refractory to drug treatment and poor developmental outcome. The genetics of epileptic ...
  • Myotonic dystrophy: application of a novel triplet-repeat-primed-pcr approach to Turkish DM patients and molecular analysis of a large Turkish kindred with Von Hippel-Lindau disease 
    Eruslu, Didem. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Myotonic Dystrophy (DM) is an autosomal dominant neuromuscular disease with multisystemic effects. DM1 and DM2 are two clinically similar types of DM that are caused by different mutations on different genes. DM1, the more ...
  • NLRC3: a new player at the crossroads of inflammasome regulation, cell proliferation and immune tolerance 
    Eren, Elif. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    NLR family proteins are cytoplasmic receptors responsible for the regulation of inflammation. Whereas some NLRs such as Cryopyrin form protein complexes recognizing pathogens and activating inflammation called the inflammasome; ...
  • Olfactory neurogenesis following acute injury 
    Çapar, Serdar. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    For most of the last century, it was believed that neurogenesis is limited to embryonic development and does not occur in the adult nervous system. However, it is now an established fact that neurogenesis also occurs in ...
  • Pharmacological characterization of the piscf - allatostatin receptor in carausius morosus 
    İşbilir, Ali. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Allatostatins (ASTs) are multifunctional insect neuropeptides that suppress juve-nile hormone (JH) synthesis and feeding behavior. Three different classes of ASTs in in-sects are known as FGLa/ASTs (A-type), MIP/ASTs ...
  • Possible interactors of alsin and effects of its expression on four motor neuron disease-related proteins 
    Çobanoğlu, Gönenç. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Motor neuron disorders, characterized by selective motor neuron degeneration, consist of a large group of diseases with overlapping genes and common pathological mechanisms. Mutations in ALS2, associated with three types ...
  • Preliminary characterization of a novel mitochondrial myopathy mouse model 
    Yılmaz, Mehmet. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Mitochondria provide a significant portion of the ATP to cells and govern cellu lar energy economics on ever-changing cellular energy requirements. Cells evolved to monitor mitochondrial stress and developed counteracting ...
  • Regulation of olfactory receptor gene choice by negative regulatory elements 
    Sancer, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In the olfactory system, each olfactory sensory neuron (OSN) typically expresses only one allele of a single olfactory receptor (OR) gene from a vast genomic repertoire. The mechanisms of OR gene choice, however, are not ...
  • Role of IroC in the fly olfactory system 
    Talay, Mustafa. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Sensory neurons, such as the visual and olfactory neurons, tend to express only one sensory receptor per neuron in order to prevent sensory overlap and then send their axons to particular target regions in the brain to ...

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