Browsing M.S. Theses by Title

Sort by: Order: Results:

  • Functional analysis of a splice site mutation in BABRG2 gene and its effect on GABAA receptor 
    Kaplan, Öyküm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Epilepsy is a group of diseases produced by non-controlled discharge of neurons affecting more than 2% of the population and some forms include genetic determinants. The principal group of inherited epilepsy is Genetic ...
  • Functional and morphological evaluation of drosophila CMT models 
    Gökerküçük, Elif Begüm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot-Marie-Tooth (CMT) disease is the most frequent inherited peripheral neuropathy in humans with a prevalence of 1 in 2500. It comprises a large group of genetically heterogeneous hereditary motor and sensory neuropathies ...
  • Functional characterization of a novel hexosaminidase, CG7985, in DROSOPHILA eye development 
    Kıral, Ferdi Rıdvan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    CG7985 is one of the four hexosaminidases encoded by the Drosophila genome. Although the other three hexosaminidases have been well-characterized in terms of their enzymatic activities and metabolic pathways in which they ...
  • Functional study of common bean isoliquiritigenin 2'-0- methyltransferase gene under salt stress 
    Niron, Harun. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Soil salinity has been one of the major problems in agriculture for many years. Nearly 20% of all cultivated land and half of irrigated land of world soil are saline and these levels are expected to rise in the future which ...
  • Functional study of certain genes selected from SSH library of common bean under salinity stress 
    Canher, Balkan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Considering that one third of Earth’s arable lands are affected by soil salinity, understanding how plants respond to salinity stress and creation of stress tolerant crops is of outmost importance. Phaseolus vulgaris (common ...
  • Further characterization of heart - and skeletal muscle-specific mitochondrial aspartyle -tRNA synthetase (DARS2) knockout mouse 
    Kartal, Özlem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Mitochondrial respiratory chain defects are the primary cause of mitochondrial disorders. Mitochondria have developed various adaptive responses to counteract the effects of these defects. In this study, the heart- and ...
  • Gene localization studies in two neurological disorders 
    Duru, Nadire. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Autozygosity mapping is a frequently used powerful method for discovering loci for autosomal recessive diseases resulting from consanguineous marriages. Gene localization is an initial step for the identification of genes ...
  • Generation of CRISPR/Cas-mediated mutants of IROC genes and protein tagging for endogenous expression analysis in drosophila 
    Çayıroğlu, Ecem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    In the olfactory system, correct olfactory receptor neuron (ORN) development depends on proper olfactory receptor (OR) gene expression and proper projection of axons to higher brain centers. Thus, during development, ORNs ...
  • Genetic analyses in Seckel syndrome and azoospermia 
    Korur, Serdar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2004., 2004.)
    The autosomal recessive genetic disorders Seckel syndrome and azoospermia were studied. In Seckel syndrome, the two known loci were tested for linkage in 15 Seckel families. In addition, four ATR interacting and fifteen ...
  • Genetic analysis in three inherited disorders 
    Bozoğlu, Tarık. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Genes responsible for inherited disorders can be localized on the genome by genetic linkage analysis. Mapping of a disease locus is accomplished by genotyping the family members with polymorphic markers in order to identify ...
  • Genetic diversity of almonds (Prunus dulcis) of Datça 
    Kaptan, Damla. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Anatolia’s agricultural biodiversity, which has evolved with the contributions of many different cultures over thousands of years, is today being rapidly eroded as a result of climate change, population growth, globalization ...
  • Genetic factors contributing to ALS in Turkey: ATXN2 polyQ repeat expansions and SNP/CNV associations 
    Ömür, Özgül. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    ALS is the most frequent motor neuron disorder and so far no cure has been developed for this devastating disease. ALS is characterized by the selective loss of both the upper motor neurons of the motor cortex and the lower ...
  • Genetically accurate models of SOD1-based ALS in Drosophila melanogaster 
    Deniz, Pınar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    ALS is a late onset, rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Generally, 5-10% of ALS patients have a family history (fALS), ...
  • Genetically accurate models of SOD1-based ALS in drosophila: validation and characterization 
    İskender, Ceren. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    SOD1 has been a unique target of ALS research as the first identified gene of the disease; since 20 years, SOD1 has not been related to any other disease unlike other ALScausing genes. There are more than 160 mutations ...
  • Genetics of hereditary sensory and autonomic neuropathy (HSAN) 
    Tezel, Seden. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2020., 2020.)
    Hereditary Sensory Neuropathy (HSN), predominantly affects sensory nerves and is characterized by sensory loss in addition to muscle weakness, wasting and painless injuries. Autonomic symptoms are commonly associated with ...
  • Genome-wide localisation analysis for IRF4 target gene identification in melanoma cell lines 
    Afshar, Ulduz Sobhi. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Interferon Regulatory Factor 4 (IRF4) is a key transcription factor in development and function of immune cells. Also it has been shown that elevated IRF4 expression is a key factor for survival in some myeloid and lymphoid ...
  • GJB1 mutation screening and in vitro investigation of its upstream mutations 
    Arı, Oğuz. (Thesis (M.A.) - Bogazici University. Institute for Graduate Studies in the Social Sciences, 2017., 2017.)
    Charcot-Marie-Tooth Type 1X (CMTX1) is the X chromosome linked form of the disease and caused by mutations in the gap junction protein 1 (GJB1) gene. This gene is the second most commonly mutated gene in all CMT forms after ...
  • Huntington's disease in Turkey: possible effects of glutamate receptor gene polymorphisms on age of disease onset 
    Erdoğan, Begüm. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Huntington’s Disease (HD) is a progressive and fatal neurodegenerative disorder that follows an autosomal dominant pattern of inheritance. The clinical symptoms of HD are disability in motor control, cognitive dysfunction ...
  • Identification and docking analysis of allatostatin receptor in Carausius morosus 
    Duan, Burçin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Allatostatin receptors (AlstRs) with their ligands (ASTs) play role in insect development, by inhibiting the production of Juvenile hormone. This thesis project uses the advances in structure-based studies and single-molecule ...
  • Identification and in vivo analysis of putative Wnt target genes with effective roles in cancer 
    Even, İpek. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    One of the most common driving forces in hepatocellular carcinoma (HCC) is the aberrant activation of the Wnt/β-catenin signaling due to the accumulation of mutant β-catenin in the cell. Our group previously detected several ...

Search Digital Archive


Browse

My Account