Browsing M.S. Theses by Title

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  • Elucidating the role of foxo transcription factors on lithium induced growth arrest in hepatocellular carcinoma cells 
    Şekerci, Esra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Lithium is one of the most effective drugs for the treatment of bipolar disorder for years. Many studies have shown that lithium has neuroprotective effect and has acapacity to inhibit cell proliferation. Specifically, it ...
  • ERK, AKT and PKA as regulatory kinases of SIK2 in FGF signaling in muller cells 
    Ejder, Funda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    FGF2 dependent retinal Müller cell proliferation is elicited mainly via activation of Ras/MAPK pathway. Phosphorylation/dephosphorylation of intermediates is one of the key mechanisms for the transient and rapid regulation ...
  • Establishment of primary human skin cell culture and soft agar transformation assay 
    Sümer, Burcu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The skin, the largest organ of the human body, is a complete closed system with various functions, including physical protection from the exterior hostile environment, sensing outside signals via its complex sensory system ...
  • Evaluation of exome sequencing data & mutation screening in GDAP1, GJB1, MPZ, NDRG1 and PMP22 genes in Turkish CMT patients 
    Sıvacı, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease which is an inherited peripheral neuropathy is an excellent candidate to be analyzed by exome sequencing because of its locus heterogeneity and low prevalence. Protein-coding regions, ‘the ...
  • Exclusion of autosomal recessive hereditary spastic paraplegia loci in Turkish families 
    Özeş, Burçak. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Hereditary spastic paraplegias (HSPs), also known as Strümpell-Lorrain disease, describe a heterogeneous group of genetic neurodegenerative disorders. The main feature of the disease is progressive spasticity in the lower ...
  • Expression analysis and behavioral assays in drosophila CMT models 
    Küey, Cansu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot–Marie–Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. It is characterized by progressive distal sensory loss and weakness, muscle atrophy in hands and lower legs, and ...
  • Expression of aFGF and FGF9 in the developing rat retina 
    Çayırlıoğlu, Pelin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Sciences and Engineering, 1995., 1997.)
    aFGF, an FGF gene family member, has been postulated to be important in the physiology and development of vertebrate retina. The distribution and relative levels of aFGF mRNA in the external photoreceptors layer, and in ...
  • Expression of fibroblast growth factors and their receptors in developing mouse dorsal root ganglia 
    Erkut, Cihan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Myelin is a key component of the nervous system where it discontinuously insulates axons and increases the speed of action potential propagation. The absence or insufficiency of myelin sheathing causes hereditary neuropathies. ...
  • Expression of SIK1 and SIK3 in postnatal rat retina 
    Vural, Muhammet Emin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Salt-inducible kinases (SIKs) have been shown to be expressed in various cells and organs including adrenocortical tissue, adipocytes and liver. They were implicated in adipocyte differentiation, steroidogenic gene expression ...
  • Functional analysis of a splice site mutation in BABRG2 gene and its effect on GABAA receptor 
    Kaplan, Öyküm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Epilepsy is a group of diseases produced by non-controlled discharge of neurons affecting more than 2% of the population and some forms include genetic determinants. The principal group of inherited epilepsy is Genetic ...
  • Functional and morphological evaluation of drosophila CMT models 
    Gökerküçük, Elif Begüm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot-Marie-Tooth (CMT) disease is the most frequent inherited peripheral neuropathy in humans with a prevalence of 1 in 2500. It comprises a large group of genetically heterogeneous hereditary motor and sensory neuropathies ...
  • Functional characterization of a novel hexosaminidase, CG7985, in DROSOPHILA eye development 
    Kıral, Ferdi Rıdvan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    CG7985 is one of the four hexosaminidases encoded by the Drosophila genome. Although the other three hexosaminidases have been well-characterized in terms of their enzymatic activities and metabolic pathways in which they ...
  • Functional study of common bean isoliquiritigenin 2'-0- methyltransferase gene under salt stress 
    Niron, Harun. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Soil salinity has been one of the major problems in agriculture for many years. Nearly 20% of all cultivated land and half of irrigated land of world soil are saline and these levels are expected to rise in the future which ...
  • Functional study of certain genes selected from SSH library of common bean under salinity stress 
    Canher, Balkan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Considering that one third of Earth’s arable lands are affected by soil salinity, understanding how plants respond to salinity stress and creation of stress tolerant crops is of outmost importance. Phaseolus vulgaris (common ...
  • Further characterization of heart - and skeletal muscle-specific mitochondrial aspartyle -tRNA synthetase (DARS2) knockout mouse 
    Kartal, Özlem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Mitochondrial respiratory chain defects are the primary cause of mitochondrial disorders. Mitochondria have developed various adaptive responses to counteract the effects of these defects. In this study, the heart- and ...
  • Gene localization studies in two neurological disorders 
    Duru, Nadire. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Autozygosity mapping is a frequently used powerful method for discovering loci for autosomal recessive diseases resulting from consanguineous marriages. Gene localization is an initial step for the identification of genes ...
  • Generation of CRISPR/Cas-mediated mutants of IROC genes and protein tagging for endogenous expression analysis in drosophila 
    Çayıroğlu, Ecem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    In the olfactory system, correct olfactory receptor neuron (ORN) development depends on proper olfactory receptor (OR) gene expression and proper projection of axons to higher brain centers. Thus, during development, ORNs ...
  • Genetic analyses in Seckel syndrome and azoospermia 
    Korur, Serdar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2004., 2004.)
    The autosomal recessive genetic disorders Seckel syndrome and azoospermia were studied. In Seckel syndrome, the two known loci were tested for linkage in 15 Seckel families. In addition, four ATR interacting and fifteen ...
  • Genetic analysis in three inherited disorders 
    Bozoğlu, Tarık. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Genes responsible for inherited disorders can be localized on the genome by genetic linkage analysis. Mapping of a disease locus is accomplished by genotyping the family members with polymorphic markers in order to identify ...
  • Genetic diversity of almonds (Prunus dulcis) of Datça 
    Kaptan, Damla. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Anatolia’s agricultural biodiversity, which has evolved with the contributions of many different cultures over thousands of years, is today being rapidly eroded as a result of climate change, population growth, globalization ...

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