Browsing M.S. Theses by Title

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  • Development of a new vaccine technology using the carrier/adjuvant properties of ASC specks 
    Alkan, Aylin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) are sensed by the nucleotide-binding oligomerization domainlike receptor (NLR) family of proteins in the cytosol for the ...
  • Development of ASC specks as carriers / adjuvants for novel vaccine technology 
    Berber, Mesut. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Pathogen associated molecular patterns (PAMPs) and danger-associated molec ular patterns (DAMPs) are sensed by nucleotide binding oligomerization domain-like receptor (NLR) family of proteins in the cytosol. Certain NLRs ...
  • Disease gene identification via linkage analysis and exome sequencing 
    Güven, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Understanding the genetic basis of hereditary diseases elucidates the molecular mechanisms underlying disease manifestations and uncovers valuable information about gene function. Consanguineous families are very useful ...
  • Disease gene search via linkage mapping and exome sequencing 
    Köroğlu Altok, Çiğdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of disease genes has a key importance in understanding the molecular mechanisms of disease pathogenesis as well as in expanding our knowledge on gene function. Linkage mapping is a powerful method to identify ...
  • Dissecting the crosstalk between inhibitory receptor signaling and the T cell receptor in natural killer cells 
    Ergün, Ebru Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Killer-cell immunoglobulin-like receptors (KIRs) are among the most prominent receptors regulating NK cell development and function. Most KIR ligands are the MHC class I molecules found on target cells. KIRs are responsible ...
  • Does blocking of firoblast growth factor-1 and its receptors affect mouse peripheral nerve myelination? 
    Şimşek, Büşra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Bi-directional communication between axon and Schwann cell is vital to the peripheral nervous system (PNS) myelination process. Disruption of this highly regulated communication is the main underlying reason of peripheral ...
  • Elucidating the role of foxo transcription factors on lithium induced growth arrest in hepatocellular carcinoma cells 
    Şekerci, Esra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Lithium is one of the most effective drugs for the treatment of bipolar disorder for years. Many studies have shown that lithium has neuroprotective effect and has acapacity to inhibit cell proliferation. Specifically, it ...
  • ERK, AKT and PKA as regulatory kinases of SIK2 in FGF signaling in muller cells 
    Ejder, Funda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    FGF2 dependent retinal Müller cell proliferation is elicited mainly via activation of Ras/MAPK pathway. Phosphorylation/dephosphorylation of intermediates is one of the key mechanisms for the transient and rapid regulation ...
  • Establishment of primary human skin cell culture and soft agar transformation assay 
    Sümer, Burcu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The skin, the largest organ of the human body, is a complete closed system with various functions, including physical protection from the exterior hostile environment, sensing outside signals via its complex sensory system ...
  • Evaluation of exome sequencing data & mutation screening in GDAP1, GJB1, MPZ, NDRG1 and PMP22 genes in Turkish CMT patients 
    Sıvacı, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease which is an inherited peripheral neuropathy is an excellent candidate to be analyzed by exome sequencing because of its locus heterogeneity and low prevalence. Protein-coding regions, ‘the ...
  • Exclusion of autosomal recessive hereditary spastic paraplegia loci in Turkish families 
    Özeş, Burçak. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Hereditary spastic paraplegias (HSPs), also known as Strümpell-Lorrain disease, describe a heterogeneous group of genetic neurodegenerative disorders. The main feature of the disease is progressive spasticity in the lower ...
  • Expression analysis and behavioral assays in drosophila CMT models 
    Küey, Cansu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot–Marie–Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. It is characterized by progressive distal sensory loss and weakness, muscle atrophy in hands and lower legs, and ...
  • Expression of aFGF and FGF9 in the developing rat retina 
    Çayırlıoğlu, Pelin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Sciences and Engineering, 1995., 1997.)
    aFGF, an FGF gene family member, has been postulated to be important in the physiology and development of vertebrate retina. The distribution and relative levels of aFGF mRNA in the external photoreceptors layer, and in ...
  • Expression of fibroblast growth factors and their receptors in developing mouse dorsal root ganglia 
    Erkut, Cihan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Myelin is a key component of the nervous system where it discontinuously insulates axons and increases the speed of action potential propagation. The absence or insufficiency of myelin sheathing causes hereditary neuropathies. ...
  • Expression of SIK1 and SIK3 in postnatal rat retina 
    Vural, Muhammet Emin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Salt-inducible kinases (SIKs) have been shown to be expressed in various cells and organs including adrenocortical tissue, adipocytes and liver. They were implicated in adipocyte differentiation, steroidogenic gene expression ...
  • Functional analysis of a splice site mutation in BABRG2 gene and its effect on GABAA receptor 
    Kaplan, Öyküm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Epilepsy is a group of diseases produced by non-controlled discharge of neurons affecting more than 2% of the population and some forms include genetic determinants. The principal group of inherited epilepsy is Genetic ...
  • Functional and morphological evaluation of drosophila CMT models 
    Gökerküçük, Elif Begüm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot-Marie-Tooth (CMT) disease is the most frequent inherited peripheral neuropathy in humans with a prevalence of 1 in 2500. It comprises a large group of genetically heterogeneous hereditary motor and sensory neuropathies ...
  • Functional characterization of a novel hexosaminidase, CG7985, in DROSOPHILA eye development 
    Kıral, Ferdi Rıdvan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    CG7985 is one of the four hexosaminidases encoded by the Drosophila genome. Although the other three hexosaminidases have been well-characterized in terms of their enzymatic activities and metabolic pathways in which they ...
  • Functional study of common bean isoliquiritigenin 2'-0- methyltransferase gene under salt stress 
    Niron, Harun. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Soil salinity has been one of the major problems in agriculture for many years. Nearly 20% of all cultivated land and half of irrigated land of world soil are saline and these levels are expected to rise in the future which ...
  • Functional study of certain genes selected from SSH library of common bean under salinity stress 
    Canher, Balkan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Considering that one third of Earth’s arable lands are affected by soil salinity, understanding how plants respond to salinity stress and creation of stress tolerant crops is of outmost importance. Phaseolus vulgaris (common ...

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