Novel axially chiral thiohydantoin derivatives bearing an o-CF3 phenyl ring have been synthesized atroposelectively from the reaction of R and S alanine, phenyl alanine and valine methyl ester HCl salts with ortho-triflu ...

Thiohydantoins have a wide range of pharmacological and biological properties. In the previous studies, nonracemic axially chiral thiohydantoins were synthesized and computational investigations have rationalized the ...

In this study, sterically hindered 5-methyl-3-(o-aryl)-2,4-oxazolidinediones and 5,5-dimethyl-3-(o-aryl)-2,4-oxazolidinediones have been synthesized by the reaction of the o-aryl isocyanates with (S)-(-)-ethyllactate or ...

This thesis consists of two parts. In the first part, axially chiral (S)-5-methyl-3-(otolyl)oxazolidine-2,4-dione was synthesized as a single enantiomer. The optical stability of C-5 chiral center of the compound was tested ...