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Browsing Moleküler Biyoloji ve Genetik by Author

Browsing Moleküler Biyoloji ve Genetik by Author "Graduate Program in Molecular Biology and Genetics."

Now showing items 1-20 of 177

A FLY's view of salt inducible kinases: a synergistic tumorigenesis model

Sayın, Sercan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)

The recent explosion of data generated by high-throughput assays on cancer necessitated reliable and fast in vivo models for evaluation new catalogue of candidate genes as tumor suppressors or proto-oncogenes and their ...
A molecular investigation of β-thalassemia in the Aegean and Mediterranean coasts of Turkey :|is there a region-dependent specificity?

Senga, Edward Bisweck. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1994., 1994.)

As in many other Mediterranean countries, β-Thalassemia is also a major public health concern in Turkey. The average gene frequency.is estimated to be two per cent, and regions with higher figures are known to exist. Country ...
A novel post-translational modification on the central CRISPR enzyme :|discovery of Cas9 ubiquitylation

Çelen, Arda Baran. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

The CRISPR/Cas9 system offers a simple method for genome engineering by utilizing the ability of the bacterial Cas9 enzyme to cleave any desired genomic region under the guidance of a complementary RNA molecule. Due to its ...
A novel tool for the identification of locus-specific chromatin proteins

Ogmen, Anna. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Genomic DNA is maintained and regulated by chromatin proteins. Methods for research of chromatin organization are numerous and established, however, it is still a challenge to identify novel chromatin proteins associated ...
A privileged hunter: role of NLRP7 in immune privilege

Demiröz, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)

NOD-like receptors (NLRs) are a family of cytoplasmic receptors with members regulating apoptosis and inflammation. NLRP7 is a novel PYRIN domain containing NLR family member and its functions are still under investigation. ...
A quest for the upstream activators of ochratoxin a (OTA)- induced MAPK/ERK1/2

Gül, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

Ochratoxin-A (OTA) is a mycotoxin, produced as a secondary metabolite by fungi belonging to Aspergillus and Penicillium genera. It has been recognized as a carcinogen in rodents and a possible carcinogen to humans. In our ...
A study for the detection of known and novel mutations in the cystic fibrosis transmembrane conductance regulator gene

Kılınç, Okyay. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1996., 1996.)

Cystic fibrosis (CF) is one of the most common and severe autosomal recessive genetic disorders worldwide. It results from mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). ...
Aberrant global DNA methylation in neurodegeneration: ALS and trinucleotide repeat disorders

Hamzeiy, Hamid. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease of the motor neurons, leading to death within two-three years of onset. Extensive studies have thus far helped identify many genetic causes for ...
Analysis of positive and negative regulatory sites and their interacting transcription factors in the zebrafish OR101-1 gene promoter

Özdemir, Metin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

Each olfactory sensory neuron (OSN) of olfactory system expresses a single allele of an olfactory receptor (OR) gene from a large genomic repertoire. How an OSN selects and activates a single OR allele is not well understood ...
Analysis of the vascular endothelial growth factor and angiogenin genes as risk factors for amyotrophic lateral sclerosis in the Turkish population; identification of a possible novel mutation

Güzel, Refika Mine. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder, which is primarily characterized by the death of motor neurons in the cerebral cortex, spinal cord, and brainstem. Degeneration of motor neurons ...
Analysis of Turkish cystic fibrosis chromosomes

Akarsubaşı, Alper Tunga. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1995., 1995.)

Cystic fibrosis (CF results from mutations in the gene encoding the cystic fibrosis transmembrane regulator (CFTR), a protein that regulates chloride ion transport in exocrine gladns. Since the cloning of the gene, more ...
Bioinformatic and molecular analysis of olfactory receptor gene regulation in zebrafish

Kaya, Ahmet Burak. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

In vertebrates, an individual olfactory sensory neuron (OSN) expresses only one allele of one olfactory receptor (OR) gene from a huge genomic repertoire. The molecular mechanism governing “one neuron-one receptor rule” ...
Cardiovascular disease in the Turkish population: molecular analysis of the renin-angiotensin system and its associated genes with premature myocardial infarction

Gencer, Pınar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

Cardiovascular disease (CVD), which is a complex multifactorial disease with many environmental and genetic factors, is the leading cause of death worldwide. Extensive research is ongoing for the identification of the ...
Characterization and regulation of human Kim-1 gene promoter the role of activator protein 1 (AP1) transchiption factor

Bergin, Tijen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)

Kidney Injury Molecule-1 (KIM-1) is an immunoglobulin superfamily cell surface protein highly upregulated on the surface of dedifferentiated renal proximal tubule epithelial cells regenerating after toxic or ischemic injury. ...
Characterization of a novel R7-specific gene in the drosophila visual system

Kaçmaz, Güner. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)

The proper functioning of the nervous system depends on the correct specification of many different cell types and the establishment of proper connections between neurons during development. The visual system of Drosophila ...
Characterization of adipokinetic hormone receptor in stick insect, Carausius Morosus

Sınmaz, Merve Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

Adipokinetic hormone (AKH) is an insect neuropeptide and known as gonadotropinreleasing hormone, which is orthologue to humans. It is released from corpora cardiaca and acts generally on fat body for energy mobilization. ...
Characterization of C170RF45 as a novel target of the Wnt/β-catenin pathway

Şeker, Tuncay. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)

β-catenin is a key component of Wnt pathway which plays an important role in tumorigenesis. In our previous study, candidate genes regulated byWnt/ β-catenin/TCF pathway were identified in hepatocellular carcinoma-derived ...
Characterization of CkIIα-i1 -a putative ortholog of intellectual disability candidate gene ZBTB11

Mandacı, Barış Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Intellectual Disability (ID) is a heterogenic neurodevelopmental disorder seen in different spectrums in affected individuals. Resulting problems in the diagnosis of ID and limitations in its treatment constitutes a great ...
Characterization of gene expression alterations in β-catenin activated Huh7 hepatocarcinoma cell lines by construction and verification of a sage library

Çavuşoğlu, Kader. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)

β-catenin, a cytoplasmic component of the Wnt signaling pathway, is observed to be aberrantly activated in several types of tumors, including hepatocellular carcinoma. The aim of this study is to identify novel genes that ...
Characterization of genes involved in photoreceptor differentiation

Öztürk, Arzu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)

The one receptor - one neuron rule is a common phenomenon observed in sensory organs. In the Drosophila eye, each photoreceptor expresses one of six different rhodopsin genes. The expression patterns of inner photoreceptors ...

Browsing Moleküler Biyoloji ve Genetik by Author "Graduate Program in Molecular Biology and Genetics."

Browsing Moleküler Biyoloji ve Genetik by Author "Graduate Program in Molecular Biology and Genetics."

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