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Browsing Moleküler Biyoloji ve Genetik by Author

Browsing Moleküler Biyoloji ve Genetik by Author "Şahin, Umut."

Now showing items 1-6 of 6

A novel post-translational modification on the central CRISPR enzyme :|discovery of Cas9 ubiquitylation

Çelen, Arda Baran. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

The CRISPR/Cas9 system offers a simple method for genome engineering by utilizing the ability of the bacterial Cas9 enzyme to cleave any desired genomic region under the guidance of a complementary RNA molecule. Due to its ...
Identification of the major sumoylation site on crispr CAS9 protein

Yeşildağ, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

CRISPR/Cas9 system is a type of adaptive immune system, which operates in prokaryotic organisms as an antiviral defense. Ever since its adaptation to eukaryotic systems as a gene editing tool, CRISPR has been one of the ...
Investigation of the effects of SUMO modification on two critical proteins : a pathogenic NEK1 mutant that drives ALS pathogenesis and the CRISPR-associated CAS9 protein

Ergünay, Tunahan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Small Ubiquitin-like modifier (SUMO) is an essential eukaryotic post-translational modification. SUMO isoforms attach to specific lysine residues on target substrates to modi-fy their function, activity, solubility and ...
Investigation of the impact of human immunodeficiency virus on cellular sumoylation

Pekbilir, Emre. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The manifestation of Human Immunodeficiency Virus type 1 (HIV-1) infection is acquired immunodeficiency syndrome (AIDS), one of the major health problems worldwide. From the first step of infection to the end, HIV-1 ...
Investigation of the pathogenic basıs of NEK1-linked amyotrophic lateral sclerosis and discovery of a potential treatment that prevents protein aggregation through targeted destruction

Öztürk, Harun. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease with dismal prognosis, characterized by motor neuron loss in the patients. More than 30 genes have been reported to be involved in ALS ...
The assessment of ubiquitin E3 ligase activity of RNF4 on ALS-related NEK1 protein

Canaslan, Sezgi (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Amyotropic lateral sclerosis (ALS) is a serious and progressive motor-neuron disease in which neurons that control voluntary muscles gradually deteriorate. Patients lose the ability to speak, move and breathe. To date, 30 ...

Browsing Moleküler Biyoloji ve Genetik by Author "Şahin, Umut."

Browsing Moleküler Biyoloji ve Genetik by Author "Şahin, Umut."

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