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Yazar "Özören, Nesrin." için Moleküler Biyoloji ve Genetik listeleme

Yazar "Özören, Nesrin." için Moleküler Biyoloji ve Genetik listeleme

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  • A privileged hunter: role of NLRP7 in immune privilege 
    Demiröz, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    NOD-like receptors (NLRs) are a family of cytoplasmic receptors with members regulating apoptosis and inflammation. NLRP7 is a novel PYRIN domain containing NLR family member and its functions are still under investigation. ...
  • Characterization of IRF4 dependency in melanoma cell lines 
    Ayhan, Mustafa Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Interferon Regulatory Factor 4 (IRF4, also known as MUM1, LSIRF, NFEM5, and ICSAT) is a transcription factor with important regulatory roles on B-cell matura-tion and differentiation. Although the first identification of ...
  • Characterization of NLRP13 in inflammasome activity 
    Yalçınkaya, Mustafa. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    NOD-like receptors (NLRs) are a family of cytoplasmic proteins with members regulating inflammation and apoptosis. NLRP13 is a novel PYRIN domain containing NLR family member and the roles of NLRP13 in these pathways is ...
  • Cloning and characterization of novel nod like receptors as cytoplasmic immune sensors 
    Gültekin, Yetiş. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    NOD like receptors recognize infection and cellular damage. They are characterized by an N terminal protein interaction domain, central oligomerization domain, termed nucleotide binding domain and leucine rich repeat domain ...
  • Development of a new vaccine technology using the carrier/adjuvant properties of ASC specks 
    Alkan, Aylin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) are sensed by the nucleotide-binding oligomerization domainlike receptor (NLR) family of proteins in the cytosol for the ...
  • Development of ASC specks as carriers / adjuvants for novel vaccine technology 
    Berber, Mesut. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Pathogen associated molecular patterns (PAMPs) and danger-associated molec ular patterns (DAMPs) are sensed by nucleotide binding oligomerization domain-like receptor (NLR) family of proteins in the cytosol. Certain NLRs ...
  • Disease gene discovery by linkage mapping and exome analysis 
    Bölükbaşı, Esra Yıldız. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Disease gene identification is an important area in genetics. Consanguineous marriages are very common in some populations and lead to emergence of rare diseases. To uncover the functions of our genes and the molecular ...
  • Divergent functions of NLRP7 in embryogenesis, inflammation and oncogenesis 
    Garipcan, Aybüke. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    NLRP7 is a novel protein about which we have limited information. To date, mutations in NLRP7 gene have been associated with recurrent Complete Hydatidiform Mole (RCHM) and NLRP7 is accepted to be the first causative gene ...
  • Establishment of primary human skin cell culture and soft agar transformation assay 
    Sümer, Burcu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The skin, the largest organ of the human body, is a complete closed system with various functions, including physical protection from the exterior hostile environment, sensing outside signals via its complex sensory system ...
  • Functional enrichment methodology for analyzing omics data to study the aetiology of rare diseases 
    Saygı, Ceren. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Rare diseases (RDs) are a large and diverse group of disorders and defined by low prevalence, in other words, it is any disease that affects a small percentage of the population. According to OMIM and Orphanet, ~7000 ...
  • Importance of ASC expression for melanoma tumorigenesis in vivo and a role for inflammasome activation in apoptosis induction 
    Çifdalöz, Metehan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    ASC is an adaptor protein which is capable of binding to numerous partners due to its two oligomerization domains, PYRIN and CARD. Its involvement in the inflammasome complex as an essential adaptor, in the regulation of ...
  • Importance of ASC expression levels in the development of chemoresistance in human melanoma cell lines 
    Erdoğan, Damla. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    ASC (Apoptosis-associated speck like protein containing a CARD) is an adapter protein containing PYRIN and CARD interaction domains. ASC is implicated in apoptosis and innate immune signaling and is required for IL-1 and ...
  • In vivo studies of ASC specks as antigen delivery vehicles 
    Yaşa, Seda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    ASC is a 22 kDa adapter protein which is an essential component of the NLRP3, NLRC4 and AIM2 in ammasome complexes. ASC has critical functions in in ammatory and pyroptotic signaling pathways via activating caspase-1. In ...
  • Investigation of homotypic PYD and CARD domain interactions in ASC speck assembly 
    Otaş, Hasan Ozan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Apoptosis-associated speck-like protein containing a CARD (ASC) is a 22 kDa protein containing conserved PYD and CARD domains that belong to death-fold superfamily. Homotypic interactions between the domains occur via ...
  • Investigation of interaction partners of NLRP13 
    Ok, Hilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    NOD-like receptors (NLRs) are the cytoplasmic members of pattern recognition receptor family, broadly with functions in inflammasome formation, signal transduction, transcription activation, cell death, reproduction, and ...
  • Investigation of NLRP13 - driven innate immune responses 
    Yılmazer, Açelya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    NOD-like receptors are the key players of inflammasome activation. NLRP13 is a primate specific member of the NLR family containing PYRIN domain and its role in inflammation is still unknown. Since there is no published ...
  • Investigation of NLRP13's cleavage and its role in macrophage polarization 
    Çıracı, Sevgi. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The NOD-like receptors (NLRs) are mainly known for their roles in inflamma tory responses and host defense against microbial pathogens, but they are also asso ciated with metabolic disorders, autophagy regulation, transcription ...
  • Investigation of the possible oncogenic role of NLRP7 in human endometrium canser 
    Olay Artık, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    NLRP7 is an innate immune protein that is involved in the activation of proin ammatory caspases by participating in in ammasome oligomerization. So far, mutations in NLRP7 have been associated with Hydatidiform Mole ...
  • Investigation of the role of NLRP13 in cell death 
    Çakır, Elif Öykü. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    NLRP13 is an intracellular protein that is included in the NOD- like receptor family. It contains the N-terminal pyrin domain, central NOD domain, and leucine-rich repeats, LRR at C terminus. Stably NLRP13 expressing THP-1 ...
  • NLRC3: a new player at the crossroads of inflammasome regulation, cell proliferation and immune tolerance 
    Eren, Elif. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    NLR family proteins are cytoplasmic receptors responsible for the regulation of inflammation. Whereas some NLRs such as Cryopyrin form protein complexes recognizing pathogens and activating inflammation called the inflammasome; ...