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Browsing Moleküler Biyoloji ve Genetik by Title

Browsing Moleküler Biyoloji ve Genetik by Title

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  • Temporal and comparative analysis of genes that play a role in brain vascular development 
    Özkan, Abdulkadir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Arteriovenous malformations (AVMs) are direct abnormal connections of arteries and draining veins without a capillary bed. AVMs, in which normal blood flow is interrupted, carry high risk of bleeding throughout life. They ...
  • The assessment of ubiquitin E3 ligase activity of RNF4 on ALS-related NEK1 protein 
    Canaslan, Sezgi (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Amyotropic lateral sclerosis (ALS) is a serious and progressive motor-neuron disease in which neurons that control voluntary muscles gradually deteriorate. Patients lose the ability to speak, move and breathe. To date, 30 ...
  • The contribution of purinergic signaling to olfactory neurogenesis in zebrafish 
    Sakızlı, Uğurcan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Compared to other sensory epithelia, the olfactory epithelium (OE) has a remarkably high regenerative capacity: continuous neurogenesis compensates for regular turnover of olfactory sensory neurons (OSNs) while reactive ...
  • The effect of nNav1.5 gene expression in breast cancer metastasis 
    Yamacı, Rezan Fahrioğlu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Breast cancer is the most common cancer among women. Its metastasis is lethal that can not be detected at microscopic levels using current techniques. Thus, there is need for reliable early metastasis markers. Neonatal ...
  • The functional role of ASP50 in protein synthesis elongation factor Tu 
    Baş, Levent. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu is an essential enzyme responsible for delivering aminoacyltRNA's to ribosomal A-site during protein synthesis. In its active GTP-bound state, it forms an EF-Tu · GTP · aminoacyl-tRNA ternary complex ...
  • The genetic diversity of the Galanthus L. species in Turkey 
    Taşçı, Nıvart. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Galanthus L., widely known as snowdrops, is a genus of bulbous monocotyledons, consisting of 19 confined species. It belongs to the family Amaryllidaceae. The genus is confined to Europe, Asia Minor, and the Near East. ...
  • The genetics of sporadic ALS: the first Turkish GWAS and novel SNP and CNV association 
    Uyan, Özgün. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Selective degeneration of both lower and upper motor neurons located in the brain cortex, brainstem and ventral horn of the spinal cord result in amyotrophic lateral sclerosis (ALS). ALS is the most frequent late-onset ...
  • The impact of mutant alsin protein on motor neuron models and the effects of alsin gene knock-down on motor protein genes 
    Lahut, Suna. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Alsin is a ubiquitously expressed protein with the highest levels in the central nervous system. Mutations in the alsin gene have been associated with several juvenile onset recessive motor neuron diseases. Nine out of 12 ...
  • The molecular basis of alpha-thalassemia in Turkey: |establishment and application of PCR-based methods 
    Taştan, A. Özlem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1996., 1996.)
    As in many other Mediterranean countries, hemoglobinopathies, especially thalassemias pose a major health concern in the Turkish population. Alpha-thalassemias, which may be the most common genetic disorders of human being, ...
  • The molecular dissection of ataxias in Turkey and the impact of whole exome sequencing in their precise differential diagnosis 
    Koçoğlu, Cemile. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Ataxias are a diverse group of genetically, clinically and mechanistically heterogeneous neurodegenerative disorders. There is significant overlap in the phenotype of different subtypes of ataxia, which can also manifest ...
  • The molecular landscape of ALS in Turkey: A multifaceted approach to the complex genetics of ALS 
    İskender, Ceren. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease (NDD), characterized by degeneration of both upper and lower motor neurons leading to muscle wasting. With an incidence of two and a prevalence ...
  • The myelination puzzle: do fibroblast growth factors and their receptors have regulatory roles in peripheral nerve myelination? 
    Dağlıkoca, Emine Duygu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Axon-Schwann cell interaction is the key step in myelination and critical in the pathogenesis of peripheral neuropathies. Molecules mediating this interaction to promote the complex mechanism of myelination have not been ...
  • The possible involvement of SIK2 in diabetic retinopathy 
    Ersoy, Burcu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Diabetic Retinopathy (DR) is one of the most common complications of diabetes and in advanced stages it is characterized by vascular abnormalities and neuronal degeneration. It is widely accepted that the functional changes ...
  • The role of EGFR and JAK 
    Alkiraz, Aysu Şevval. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The zebrafish olfactory epithelium (OE) has an exceptional neurogenic capacity, which supports the continuous turnover olfactory sensory neurons (OSNs) and efficient regeneration after injury. These processes depend on the ...
  • The role of MAPK and AKT signaling during zebrafish olfactory epithelium regeneration 
    Dokuzluoğlu, Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The zebrafish olfactory epithelium (OE) is a neuroepithelium that is able to re generate neurons. The ability of the OE for neuron regeneration stems from the pres ence of a dual progenitor system that persists to the ...
  • The role of sustentacular cells in adult neurogenesis 
    Bali, Burak. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    The olfactory epithelium (OE) provides a unique exception to the limited ability of the nervous system to regenerate itself. Olfactory sensory neurons (OSN) are directly exposed to the outside world, prone to environmental ...
  • The role of theodorant receptor coding sequence in the regulation of odorant receptor transgene expression in Zebrafish 
    Taştekin, İbrahim. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Odorant receptors constitute the largest gene family in rodents and probably in all vertebrates. In addition to detecting the odorant molecules in the outside world, odorant receptorrs are responsible for some critical ...
  • The role of unzipped axon guidance and targeting in the olfactory system of drosophila melanogaster 
    Mika, Kaan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    The olfactory system of Drosophila is a great model to investigate neural wiring complexity. The fly has two sensory appendages named as antenna and maxillary palp. Hair-like structures called as sensilla cover the appendages ...
  • The role of WNT signaling during regenerative neurogenesis in the zebrafish olfactory epithelium 
    Eski, Sema Elif. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    The peripheral olfactory epithelium (OE) is a potentially insightful exception to the limited capacity of neurogenesis in the adult nervous system. The OE undergoes continuous generation of olfactory sensory neurons (OSNs) ...
  • Transcriptome - wide analysis of iroc target genes in the drosophila olfactory system 
    Taşkıran, İbrahim İhsan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Sensing the environment is vital for an organism and it is provided by divergent sensory neurons. These neurons are generated from sensory organ precursor (SOP) cells that differentiate into neurons with diverse spectral ...

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