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Browsing Moleküler Biyoloji ve Genetik by Title

Browsing Moleküler Biyoloji ve Genetik by Title

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  • Defining novel cancer genes, sage tags and co-regulated regions of the human genome evolving from the search and identification of novel Wnt/TCF/B-catenin targets 
    Kavak, Erşen. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The Wnt signaling pathway is involved in many differentiation events during embryonic development and can lead to tumor formation after aberrant activation of its components. β-catenin, a cytoplasmic component, plays a ...
  • Detection of DNA duplications in charcot-marie-tooth type 1 (CMT1) patients by DNA analysis 
    Bissar-Tadmouri, Nisrine. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1997., 1997.)
    Charcot-Marie-Tooth neuropathy (CMT), also known as Hereditary Motor and Sensory Neuropathy (HMSN), is a heterogeneous group of inherited diseases of peripheral nerves. It is estimated that 112500 persons have a form of ...
  • Determination of genetic diversity of rhododendron species in Turkey 
    Kaya, İsmail Tuğberk. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    The Rhododendrons of Turkey are presented by 10 taxa and they grow naturally along the coast of the Black Sea region from Artvin province at the east to Istranca Mountains at the west. Although in many countries, cultivated ...
  • Development & application of novel methods to identify locus-specific transcriptional regulators 
    Selcen, İpek. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Chromatin-associated factors play important roles in the regulation of gene expression. It is essential to identify these factors in order to elucidate their functional roles at the target sites. There are a number of ...
  • Development and molecular analysis of CMT4B1 drosophila model 
    Kılınç, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. Among about 40 genes associated with the disease, MTMR2 loss-of-function mutations are classified as CMT4B1 subtype. ...
  • Development of a drosophila CMT model via overexpression and knocking-in of GDAP1 gene 
    Akyüz, Hüseyin Kaya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is one of the most common inherited disorders of the nervous system. Known also as hereditary motor and sensory neuropathy, this disease is characterized by distal sensory loss, muscle ...
  • Development of a drosophila CMT4A model using imago approach 
    Yıldırım, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. So far, approximately 50 genes and loci have been associated with CMT. Mutations in ganglioside-induced differentiation-associated protein ...
  • Development of a new vaccine technology using the carrier/adjuvant properties of ASC specks 
    Alkan, Aylin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) are sensed by the nucleotide-binding oligomerization domainlike receptor (NLR) family of proteins in the cytosol for the ...
  • Development of ASC specks as carriers / adjuvants for novel vaccine technology 
    Berber, Mesut. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Pathogen associated molecular patterns (PAMPs) and danger-associated molec ular patterns (DAMPs) are sensed by nucleotide binding oligomerization domain-like receptor (NLR) family of proteins in the cytosol. Certain NLRs ...
  • Development of single cell genetic testing strategies : assessment of MHC compatibility, meiotic recombinations and beta-thalassemia in human embryos 
    Taylan, Fulya. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Single cell molecular biology, a relatively new scientific branch, is promising to study unique questions and leading to novel applications in biology and medicine. Single cell studies have been challenged by difficulties ...
  • Disease gene discovery by linkage mapping and exome analysis 
    Bölükbaşı, Esra Yıldız. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Disease gene identification is an important area in genetics. Consanguineous marriages are very common in some populations and lead to emergence of rare diseases. To uncover the functions of our genes and the molecular ...
  • Disease gene identification via linkage analysis and exome sequencing 
    Güven, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Understanding the genetic basis of hereditary diseases elucidates the molecular mechanisms underlying disease manifestations and uncovers valuable information about gene function. Consanguineous families are very useful ...
  • Disease gene search via linkage mapping and exome sequencing 
    Köroğlu Altok, Çiğdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of disease genes has a key importance in understanding the molecular mechanisms of disease pathogenesis as well as in expanding our knowledge on gene function. Linkage mapping is a powerful method to identify ...
  • Dissecting the crosstalk between inhibitory receptor signaling and the T cell receptor in natural killer cells 
    Ergün, Ebru Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Killer-cell immunoglobulin-like receptors (KIRs) are among the most prominent receptors regulating NK cell development and function. Most KIR ligands are the MHC class I molecules found on target cells. KIRs are responsible ...
  • Divergent functions of NLRP7 in embryogenesis, inflammation and oncogenesis 
    Garipcan, Aybüke. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    NLRP7 is a novel protein about which we have limited information. To date, mutations in NLRP7 gene have been associated with recurrent Complete Hydatidiform Mole (RCHM) and NLRP7 is accepted to be the first causative gene ...
  • Does blocking of firoblast growth factor-1 and its receptors affect mouse peripheral nerve myelination? 
    Şimşek, Büşra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Bi-directional communication between axon and Schwann cell is vital to the peripheral nervous system (PNS) myelination process. Disruption of this highly regulated communication is the main underlying reason of peripheral ...
  • Effects of extremely low frequency electromagnetic fields on caspase activities 
    Ozansoy, Mehmet. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    All life on Earth is bathed in a sea of natural low-frequency electromagnetic fields from conception to death. Since the World Health Organization (WHO) launched its international electromagnetic fields (EMF) project in ...
  • Elucidating the role of foxo transcription factors on lithium induced growth arrest in hepatocellular carcinoma cells 
    Şekerci, Esra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Lithium is one of the most effective drugs for the treatment of bipolar disorder for years. Many studies have shown that lithium has neuroprotective effect and has acapacity to inhibit cell proliferation. Specifically, it ...
  • Elucidating the role of unzipped in the visual system of drosophila 
    Terzioğlu Kara, Ece. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    The Drosophila eye is composed of 800 ommatidial units, each containing eight photoreceptors (PR). The outer PRs R1-R6 are responsible for motion detection, while the inner PRs R7 and R8 and are responsible for colour ...
  • ERK, AKT and PKA as regulatory kinases of SIK2 in FGF signaling in muller cells 
    Ejder, Funda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    FGF2 dependent retinal Müller cell proliferation is elicited mainly via activation of Ras/MAPK pathway. Phosphorylation/dephosphorylation of intermediates is one of the key mechanisms for the transient and rapid regulation ...

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