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Browsing Moleküler Biyoloji ve Genetik by Title

Browsing Moleküler Biyoloji ve Genetik by Title

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  • Class restriction in odorant receptor gene regulation 
    Tınaztepe, Emir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Odorant receptors which partake in the detection of both water-soluble and airborne chemicals constitute the largest family of seven-transmembrane G-Protein-Coupled Receptors in the majority of vertebrates. Since their ...
  • Clonal analysis of compensatory proliferation in dmHexDC mutants 
    Başdağ, Bilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Recycling of sugar-containing organic compounds (saccharides) have importance for metabolic activity, cellular growth, and differentiation. During this recycling process, many enzymes, primarily lysosomal enzymes, play a ...
  • Cloning and characterization of novel nod like receptors as cytoplasmic immune sensors 
    Gültekin, Yetiş. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    NOD like receptors recognize infection and cellular damage. They are characterized by an N terminal protein interaction domain, central oligomerization domain, termed nucleotide binding domain and leucine rich repeat domain ...
  • Cloning, expression and purfication of the recombinant DNA polymerase I from the hyperthermophilic bacteria geobacillus anatolicus 
    Çağlayan, Melike. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2005., 2005.)
    The DNA polymerase I gene of a recently described Geobacillus species, Geobacillus anatolicus from a terrestrial hydrothermal vent has been cloned and expressed in Escherichia coli. Evolutionarily conserved regions of DNA ...
  • Cloning, expression and purification of recombinant elongation factor Ts from hyperthermophilic bacteria Geobacillus Anatolicus 
    Şahin, Toros. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Elongation factor EF-Ts from Geobacillus anatolicus was cloned, expressed and purifed as a His-tagged recombinant protein in Escherichia coli. The first step in this study was the determination of the nucleic acid sequence ...
  • Cloning, expression and purification of recombinant elongation factor Tu from hyperthermophilic bacteria Geobacillus Anatolicus 
    Akalın, Barış. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    In this study, elongation factor Tu (EF-Tu) from Geobacillus anatolicus was cloned, expressed and purifed as a His-tagged recombinant protein in Escherichia coli. At first, the nucleic acid sequence of Geobacillus anatolicus ...
  • Co-expression of odorant receptor genes in zebrafish 
    Atasoy, Arif Murat. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Olfactory receptors constitute the largest G-Protein-Coupled Receptor family in humans and in other vertebrates. Olfactory receptor genes are expressed in the olfactory sensory neurons in the olfactory epithelia and are ...
  • Co-receptor mediated regulation of T cell receptor signalling in natural killer cells 
    Karahan, Zeynep Sena. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Antigen-specific cancer immunotherapy has been developing since the 1990s and showing promising results. T cell receptors (TCR) and Chimeric antigen receptors (CAR) are the most commonly used tools for modifying T cells ...
  • Defining novel cancer genes, sage tags and co-regulated regions of the human genome evolving from the search and identification of novel Wnt/TCF/B-catenin targets 
    Kavak, Erşen. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The Wnt signaling pathway is involved in many differentiation events during embryonic development and can lead to tumor formation after aberrant activation of its components. β-catenin, a cytoplasmic component, plays a ...
  • Detection of DNA duplications in charcot-marie-tooth type 1 (CMT1) patients by DNA analysis 
    Bissar-Tadmouri, Nisrine. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1997., 1997.)
    Charcot-Marie-Tooth neuropathy (CMT), also known as Hereditary Motor and Sensory Neuropathy (HMSN), is a heterogeneous group of inherited diseases of peripheral nerves. It is estimated that 112500 persons have a form of ...
  • Determination of genetic diversity of rhododendron species in Turkey 
    Kaya, İsmail Tuğberk. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    The Rhododendrons of Turkey are presented by 10 taxa and they grow naturally along the coast of the Black Sea region from Artvin province at the east to Istranca Mountains at the west. Although in many countries, cultivated ...
  • Development & application of novel methods to identify locus-specific transcriptional regulators 
    Selcen, İpek. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Chromatin-associated factors play important roles in the regulation of gene expression. It is essential to identify these factors in order to elucidate their functional roles at the target sites. There are a number of ...
  • Development and molecular analysis of CMT4B1 drosophila model 
    Kılınç, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. Among about 40 genes associated with the disease, MTMR2 loss-of-function mutations are classified as CMT4B1 subtype. ...
  • Development of a drosophila CMT model via overexpression and knocking-in of GDAP1 gene 
    Akyüz, Hüseyin Kaya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is one of the most common inherited disorders of the nervous system. Known also as hereditary motor and sensory neuropathy, this disease is characterized by distal sensory loss, muscle ...
  • Development of a drosophila CMT4A model using imago approach 
    Yıldırım, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. So far, approximately 50 genes and loci have been associated with CMT. Mutations in ganglioside-induced differentiation-associated protein ...
  • Development of a new vaccine technology using the carrier/adjuvant properties of ASC specks 
    Alkan, Aylin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) are sensed by the nucleotide-binding oligomerization domainlike receptor (NLR) family of proteins in the cytosol for the ...
  • Development of ASC specks as carriers / adjuvants for novel vaccine technology 
    Berber, Mesut. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Pathogen associated molecular patterns (PAMPs) and danger-associated molec ular patterns (DAMPs) are sensed by nucleotide binding oligomerization domain-like receptor (NLR) family of proteins in the cytosol. Certain NLRs ...
  • Development of single cell genetic testing strategies : assessment of MHC compatibility, meiotic recombinations and beta-thalassemia in human embryos 
    Taylan, Fulya. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Single cell molecular biology, a relatively new scientific branch, is promising to study unique questions and leading to novel applications in biology and medicine. Single cell studies have been challenged by difficulties ...
  • Disease gene discovery by linkage mapping and exome analysis 
    Bölükbaşı, Esra Yıldız. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Disease gene identification is an important area in genetics. Consanguineous marriages are very common in some populations and lead to emergence of rare diseases. To uncover the functions of our genes and the molecular ...
  • Disease gene identification via linkage analysis and exome sequencing 
    Güven, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Understanding the genetic basis of hereditary diseases elucidates the molecular mechanisms underlying disease manifestations and uncovers valuable information about gene function. Consanguineous families are very useful ...

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