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Browsing Moleküler Biyoloji ve Genetik by Title

Browsing Moleküler Biyoloji ve Genetik by Title

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  • Spinocerebellar Ataxia TYPE 2: Ataxin-2 mechanisms and boold biomarkers 
    Şen, Nesli Ece. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Spinocerebellar Ataxia Type 2 is an autosomal dominant movement disorder caused by trinucleotide expansions in the ATXN2 gene (>34 CAG repeats). Intermediate expansions of 26-39 repeats are considered as risk factors for ...
  • Spinocerebellar ataxias 8, 12 and 14 in Turkey: molecular bases and genetic analyses 
    Saner, Nazan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous groupof neurodegenerative disorders that are inherited in an autosomal dominant manner. Sincethe clinical symptoms of SCA subtypes significantly ...
  • Structural aspects of ASC speck formation and its potential novel functions 
    Sahillioğlu, Ali Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
  • Studies on phosphorylation of elongation factor Tu in escherichia coli 
    Kaya, H. Özen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Protein synthesis is a vital process for living organisms. Synthesis of proteins are important for cell survival and reproduction. Protein synthesis takes place on ribosomes in all prokaryotic and eukaryotic cells. Amino ...
  • Study of the polymerization dynamics of ASC and its domains 
    Kuzucu, Hulusi Onur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Apoptosis-associated speck-like protein containing a CARD (ASC) is a 22 kDa protein composed of two conserved death-fold domains, PYD and CARD, that act as an adaptor protein in in ammasomes, multimolecular complexes that ...
  • Studying the role of phosphorylation of bacterial protein synthesis elongation factor Tu 
    Kaplan, Uğur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu (EF-Tu) plays a crucial role of carrying aminoacylated-tRNA molecules to the ribosome during the elongation phase of protein synthesis. Being a guanine nucleotide binding protein, EF-Tu is inactive ...
  • Temporal and comparative analysis of genes that play a role in brain vascular development 
    Özkan, Abdulkadir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Arteriovenous malformations (AVMs) are direct abnormal connections of arteries and draining veins without a capillary bed. AVMs, in which normal blood flow is interrupted, carry high risk of bleeding throughout life. They ...
  • The assessment of ubiquitin E3 ligase activity of RNF4 on ALS-related NEK1 protein 
    Canaslan, Sezgi (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Amyotropic lateral sclerosis (ALS) is a serious and progressive motor-neuron disease in which neurons that control voluntary muscles gradually deteriorate. Patients lose the ability to speak, move and breathe. To date, 30 ...
  • The contribution of purinergic signaling to olfactory neurogenesis in zebrafish 
    Sakızlı, Uğurcan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Compared to other sensory epithelia, the olfactory epithelium (OE) has a remarkably high regenerative capacity: continuous neurogenesis compensates for regular turnover of olfactory sensory neurons (OSNs) while reactive ...
  • The effect of nNav1.5 gene expression in breast cancer metastasis 
    Yamacı, Rezan Fahrioğlu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Breast cancer is the most common cancer among women. Its metastasis is lethal that can not be detected at microscopic levels using current techniques. Thus, there is need for reliable early metastasis markers. Neonatal ...
  • The functional role of ASP50 in protein synthesis elongation factor Tu 
    Baş, Levent. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu is an essential enzyme responsible for delivering aminoacyltRNA's to ribosomal A-site during protein synthesis. In its active GTP-bound state, it forms an EF-Tu · GTP · aminoacyl-tRNA ternary complex ...
  • The genetic diversity of the Galanthus L. species in Turkey 
    Taşçı, Nıvart. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Galanthus L., widely known as snowdrops, is a genus of bulbous monocotyledons, consisting of 19 confined species. It belongs to the family Amaryllidaceae. The genus is confined to Europe, Asia Minor, and the Near East. ...
  • The genetics of sporadic ALS: the first Turkish GWAS and novel SNP and CNV association 
    Uyan, Özgün. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Selective degeneration of both lower and upper motor neurons located in the brain cortex, brainstem and ventral horn of the spinal cord result in amyotrophic lateral sclerosis (ALS). ALS is the most frequent late-onset ...
  • The impact of mutant alsin protein on motor neuron models and the effects of alsin gene knock-down on motor protein genes 
    Lahut, Suna. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Alsin is a ubiquitously expressed protein with the highest levels in the central nervous system. Mutations in the alsin gene have been associated with several juvenile onset recessive motor neuron diseases. Nine out of 12 ...
  • The molecular basis of alpha-thalassemia in Turkey: |establishment and application of PCR-based methods 
    Taştan, A. Özlem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1996., 1996.)
    As in many other Mediterranean countries, hemoglobinopathies, especially thalassemias pose a major health concern in the Turkish population. Alpha-thalassemias, which may be the most common genetic disorders of human being, ...
  • The molecular dissection of ataxias in Turkey and the impact of whole exome sequencing in their precise differential diagnosis 
    Koçoğlu, Cemile. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Ataxias are a diverse group of genetically, clinically and mechanistically heterogeneous neurodegenerative disorders. There is significant overlap in the phenotype of different subtypes of ataxia, which can also manifest ...
  • The molecular landscape of ALS in Turkey: A multifaceted approach to the complex genetics of ALS 
    İskender, Ceren. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease (NDD), characterized by degeneration of both upper and lower motor neurons leading to muscle wasting. With an incidence of two and a prevalence ...
  • The myelination puzzle: do fibroblast growth factors and their receptors have regulatory roles in peripheral nerve myelination? 
    Dağlıkoca, Emine Duygu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Axon-Schwann cell interaction is the key step in myelination and critical in the pathogenesis of peripheral neuropathies. Molecules mediating this interaction to promote the complex mechanism of myelination have not been ...
  • The possible involvement of SIK2 in diabetic retinopathy 
    Ersoy, Burcu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Diabetic Retinopathy (DR) is one of the most common complications of diabetes and in advanced stages it is characterized by vascular abnormalities and neuronal degeneration. It is widely accepted that the functional changes ...
  • The role of EGFR and JAK 
    Alkiraz, Aysu Şevval. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The zebrafish olfactory epithelium (OE) has an exceptional neurogenic capacity, which supports the continuous turnover olfactory sensory neurons (OSNs) and efficient regeneration after injury. These processes depend on the ...

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