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Browsing Moleküler Biyoloji ve Genetik by Title

Browsing Moleküler Biyoloji ve Genetik by Title

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  • SIK2 expression in retinal cells and its possible involvement along with PKA in FGF9 signal transduction 
    Özmen, Yeşim. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    FGF signal transduction pathway activates a cascade of kinase and phosphatase dependent phosphorylation and dephosphorylation events. The pathway is subject to tight control mechanisms through negative feedback exerted by ...
  • SIK2 functions as a novel tumor suppressor in the breast tumorigenesis 
    Zohrap, Neslihan. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Breast cancer has highly malignant phenotype and is the leading cause of cancer death in women. The heterogenous character of the disease points to the importance of novel target identification for the development of ...
  • SIK2 involvement in dowregulation of FGF signaling through Gab1 and Raf1 
    Sert, Yeliz Yılmaz. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Proliferative response of Müller cells to FGF2 is propagated via Ras/MAPK pathway, and involves rapid and transient ERK1/2 activation. Results from our laboratory implicate SIK2 in the regulation of FGF2 signaling via ...
  • SIK2 is potential mediator of cross-talk between FGF and PKA pathways 
    Candaş, Demet. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)
    FGF signaling pathway is initiated upon FGF binding to RTKs and the signal transduction is achieved by a series of phosphorylation/dephosphorylation events mediated by several kinase and phosphatases. The pathway is tightly ...
  • SIK2: a key player in FGF2-induced proliferation and insulin-induced survivale/hyperglycemia-dependent apoptosis in müller cells 
    Küser, Gamze. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Salt inducible kinase 2 (SIK2), a serine/threonine kinase, is primarily expressed in insulin-responsive tissues. It was suggested that SIK2 might be involved in type 2 diabetes by phosphorylating S789 residue of IRS1. In ...
  • SIK3 involvement in FGF2 signaling in Müller cells 
    Koca, Yıldız. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    FGF2 stimulation of Millier cells regulates several processes including cell proliferation and survival by triggering the activation RaslMAPK and PI3K1 Akt pathways. Data from our lab indicate that serine/threonine kinase ...
  • Spinocerebellar Ataxia TYPE 2: Ataxin-2 mechanisms and boold biomarkers 
    Şen, Nesli Ece. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Spinocerebellar Ataxia Type 2 is an autosomal dominant movement disorder caused by trinucleotide expansions in the ATXN2 gene (>34 CAG repeats). Intermediate expansions of 26-39 repeats are considered as risk factors for ...
  • Spinocerebellar ataxias 8, 12 and 14 in Turkey: molecular bases and genetic analyses 
    Saner, Nazan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous groupof neurodegenerative disorders that are inherited in an autosomal dominant manner. Sincethe clinical symptoms of SCA subtypes significantly ...
  • Structural aspects of ASC speck formation and its potential novel functions 
    Sahillioğlu, Ali Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
  • Studies on phosphorylation of elongation factor Tu in escherichia coli 
    Kaya, H. Özen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Protein synthesis is a vital process for living organisms. Synthesis of proteins are important for cell survival and reproduction. Protein synthesis takes place on ribosomes in all prokaryotic and eukaryotic cells. Amino ...
  • Study of the polymerization dynamics of ASC and its domains 
    Kuzucu, Hulusi Onur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Apoptosis-associated speck-like protein containing a CARD (ASC) is a 22 kDa protein composed of two conserved death-fold domains, PYD and CARD, that act as an adaptor protein in in ammasomes, multimolecular complexes that ...
  • Studying the role of phosphorylation of bacterial protein synthesis elongation factor Tu 
    Kaplan, Uğur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu (EF-Tu) plays a crucial role of carrying aminoacylated-tRNA molecules to the ribosome during the elongation phase of protein synthesis. Being a guanine nucleotide binding protein, EF-Tu is inactive ...
  • Temporal and comparative analysis of genes that play a role in brain vascular development 
    Özkan, Abdulkadir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Arteriovenous malformations (AVMs) are direct abnormal connections of arteries and draining veins without a capillary bed. AVMs, in which normal blood flow is interrupted, carry high risk of bleeding throughout life. They ...
  • The assessment of ubiquitin E3 ligase activity of RNF4 on ALS-related NEK1 protein 
    Canaslan, Sezgi (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Amyotropic lateral sclerosis (ALS) is a serious and progressive motor-neuron disease in which neurons that control voluntary muscles gradually deteriorate. Patients lose the ability to speak, move and breathe. To date, 30 ...
  • The contribution of purinergic signaling to olfactory neurogenesis in zebrafish 
    Sakızlı, Uğurcan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Compared to other sensory epithelia, the olfactory epithelium (OE) has a remarkably high regenerative capacity: continuous neurogenesis compensates for regular turnover of olfactory sensory neurons (OSNs) while reactive ...
  • The effect of nNav1.5 gene expression in breast cancer metastasis 
    Yamacı, Rezan Fahrioğlu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Breast cancer is the most common cancer among women. Its metastasis is lethal that can not be detected at microscopic levels using current techniques. Thus, there is need for reliable early metastasis markers. Neonatal ...
  • The functional role of ASP50 in protein synthesis elongation factor Tu 
    Baş, Levent. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu is an essential enzyme responsible for delivering aminoacyltRNA's to ribosomal A-site during protein synthesis. In its active GTP-bound state, it forms an EF-Tu · GTP · aminoacyl-tRNA ternary complex ...
  • The genetic diversity of the Galanthus L. species in Turkey 
    Taşçı, Nıvart. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Galanthus L., widely known as snowdrops, is a genus of bulbous monocotyledons, consisting of 19 confined species. It belongs to the family Amaryllidaceae. The genus is confined to Europe, Asia Minor, and the Near East. ...
  • The genetics of sporadic ALS: the first Turkish GWAS and novel SNP and CNV association 
    Uyan, Özgün. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Selective degeneration of both lower and upper motor neurons located in the brain cortex, brainstem and ventral horn of the spinal cord result in amyotrophic lateral sclerosis (ALS). ALS is the most frequent late-onset ...
  • The impact of mutant alsin protein on motor neuron models and the effects of alsin gene knock-down on motor protein genes 
    Lahut, Suna. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Alsin is a ubiquitously expressed protein with the highest levels in the central nervous system. Mutations in the alsin gene have been associated with several juvenile onset recessive motor neuron diseases. Nine out of 12 ...

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