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Browsing Moleküler Biyoloji ve Genetik by Title

Browsing Moleküler Biyoloji ve Genetik by Title

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  • Importance of ASC expression for melanoma tumorigenesis in vivo and a role for inflammasome activation in apoptosis induction 
    Çifdalöz, Metehan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    ASC is an adaptor protein which is capable of binding to numerous partners due to its two oligomerization domains, PYRIN and CARD. Its involvement in the inflammasome complex as an essential adaptor, in the regulation of ...
  • Importance of ASC expression levels in the development of chemoresistance in human melanoma cell lines 
    Erdoğan, Damla. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    ASC (Apoptosis-associated speck like protein containing a CARD) is an adapter protein containing PYRIN and CARD interaction domains. ASC is implicated in apoptosis and innate immune signaling and is required for IL-1 and ...
  • In vitro and in vivo characterization of dmHexDC function 
    Erkol, Emir. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2019.)
    Glycosylation of molecules is crucial for a wide variety of cellular processes ranging from cell-cell communication to cell differentiation and is altered in many neurodevelopmental disorders. β-hexosaminidases process ...
  • In vivo characterization of the OR101-1 gene proximal promoter region in zebrafish 
    Kazcı, Yusuf E.. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In vertebrates, each olfactory sensory neuron (OSN) of the nose expresses only a single allele of a single molecular chemoreceptor gene from a large genomic repertoire. This monogenic mode of olfactory receptor (OR) ...
  • In vivo studies of ASC specks as antigen delivery vehicles 
    Yaşa, Seda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    ASC is a 22 kDa adapter protein which is an essential component of the NLRP3, NLRC4 and AIM2 in ammasome complexes. ASC has critical functions in in ammatory and pyroptotic signaling pathways via activating caspase-1. In ...
  • Investigating the role of G protein coupled receptor (GPCR) activation in ochratoxin a (OTA)- induced toxicity 
    Aylan, Beren. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Ochratoxin A is recognized as a strong nephrotoxin accumulating and initiating cellular damage in kidney proximal tubule cells. OTA exerts its effects both on cell sur vival and cell death via the deregulation of mitogen ...
  • Investigation of homotypic PYD and CARD domain interactions in ASC speck assembly 
    Otaş, Hasan Ozan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Apoptosis-associated speck-like protein containing a CARD (ASC) is a 22 kDa protein containing conserved PYD and CARD domains that belong to death-fold superfamily. Homotypic interactions between the domains occur via ...
  • Investigation of in vitro and in vivo effects of ochratoxin a on autophagy and ubiquitin - proteasome system 
    Akpınar, Hafıze Ayşin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium genera of fungi and contaminates food and feed. OTA deregulates various signaling pathways and provokes oxidative stress along with augmentation of ...
  • Investigation of interaction partners of NLRP13 
    Ok, Hilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    NOD-like receptors (NLRs) are the cytoplasmic members of pattern recognition receptor family, broadly with functions in inflammasome formation, signal transduction, transcription activation, cell death, reproduction, and ...
  • Investigation of IRF4-MEF2D protein-protein interaction in melanoma cells 
    Hedaya, Laila Samir Abed. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    Cancer is a leading cause of death worldwide. Protein-protein interactions (PPIs) constitute a fundamental unit of the oncogenic signaling pathways that stimulate survival, growth and proliferation of cancer cells. Therefore, ...
  • Investigation of molecular signals regulating cell proliferation and neurogenesis in the intact and injured Zebrafish (Danio rerio) olfactory epithelium 
    Demirler, Mehmet Can. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    The zebrafish olfactory epithelium (OE) can recover from the near total loss of olfactory sensory neurons (OSNs) within only a week when the OE is damaged by external causes. This remarkable neurogenic activity depends ...
  • Investigation of motor neuron diseases by wes: genetic dissection of a Turkish ALS cohort 
    Akçimen, Fulya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is characterized by muscle weakness and atrophy due to the degeneration of motor neurons in the motor cortex, brain stem and spinal cord. Both ...
  • Investigation of NLRP13 - driven innate immune responses 
    Yılmazer, Açelya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    NOD-like receptors are the key players of inflammasome activation. NLRP13 is a primate specific member of the NLR family containing PYRIN domain and its role in inflammation is still unknown. Since there is no published ...
  • Investigation of NLRP13's cleavage and its role in macrophage polarization 
    Çıracı, Sevgi. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The NOD-like receptors (NLRs) are mainly known for their roles in inflamma tory responses and host defense against microbial pathogens, but they are also asso ciated with metabolic disorders, autophagy regulation, transcription ...
  • Investigation of novel recessive causative genes and gene / allele frequency for CMT disease in Turkey 
    Candayan, Ayşe. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    Inherited peripheral neuropathies are a group of genetic disorders of the periph eral nervous system. The most common type is called Charcot-Marie-Tooth (CMT) disease that constitutes an interesting research focus due to ...
  • Investigation of potential ERK-dependent phosphorylation sites on SIK2 
    Taşöz, Emirhan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    The previous studies from our laboratory suggested that the serine/threonine kinase SIK2 is involved in a feedback mechanism downregulating the FGF-dependent MAPK pathway. As it has been shown that the activity of SIK2 is ...
  • Investigation of the effects of NF-kB on ota induced apoptosis in HK-2 cell line 
    Gürkaşlar, Can. (Thesis (M.A.) - Bogazici University. Institute for Graduate Studies in the Social Sciences, 2018., 2018.)
    Ocharoxin A (OTA) is a mycotoxin produced by certain species of Aspergillus and Peni cillium genera of fungi. OTA was shown to be carcinogenic, genotoxic, immunotoxic by many studies and main suspected causative agent for ...
  • Investigation of the effects of ochratoxin-a on global protein sumoylation 
    Denizli, İrem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Ochratoxin A (OTA), a secondary metabolite produced by especially Aspergillus and Penicillium species, is found as a contaminant in foods such as daily consumed corn flakes, coffee, meat and dairy products. OTA is a potential ...
  • Investigation of the effects of SUMO modification on two critical proteins : a pathogenic NEK1 mutant that drives ALS pathogenesis and the CRISPR-associated CAS9 protein 
    Ergünay, Tunahan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Small Ubiquitin-like modifier (SUMO) is an essential eukaryotic post-translational modification. SUMO isoforms attach to specific lysine residues on target substrates to modi-fy their function, activity, solubility and ...
  • Investigation of the impact of human immunodeficiency virus on cellular sumoylation 
    Pekbilir, Emre. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The manifestation of Human Immunodeficiency Virus type 1 (HIV-1) infection is acquired immunodeficiency syndrome (AIDS), one of the major health problems worldwide. From the first step of infection to the end, HIV-1 ...

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