Arşiv ve Dokümantasyon Merkezi
Dijital Arşivi

Yayın tarihi için Moleküler Biyoloji ve Genetik listeleme

Yayın tarihi için Moleküler Biyoloji ve Genetik listeleme

Sırala: Sıra: Sonuçlar:

  • Disease gene identification via linkage analysis and exome sequencing 
    Güven, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Understanding the genetic basis of hereditary diseases elucidates the molecular mechanisms underlying disease manifestations and uncovers valuable information about gene function. Consanguineous families are very useful ...
  • Schizophrenia: another emphasis of ERBB4 and NRG1 impact on disease development 
    Ağım, Zeynep Sena. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Schizophrenia, which is one of the most commonly reported illnesses among all psychiatric disorders, is defined as a complex disease; this implicates that it does not show a simple Mendelian pattern of inheritance. The ...
  • Identification and docking analysis of allatostatin receptor in Carausius morosus 
    Duan, Burçin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Allatostatin receptors (AlstRs) with their ligands (ASTs) play role in insect development, by inhibiting the production of Juvenile hormone. This thesis project uses the advances in structure-based studies and single-molecule ...
  • A privileged hunter: role of NLRP7 in immune privilege 
    Demiröz, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    NOD-like receptors (NLRs) are a family of cytoplasmic receptors with members regulating apoptosis and inflammation. NLRP7 is a novel PYRIN domain containing NLR family member and its functions are still under investigation. ...
  • Identification of the role of a novel cell adhesion molecule, unzipped, in mediating neuron-glia interactions in drosophila 
    Zülbahar, Selen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The intricate but still precise pattern of brain circuitry is unquestionably the most complex feature of both vertebrates and invertebrates. How that complex circuitry develops has been the subject of intense study for ...
  • Genetic diversity of almonds (Prunus dulcis) of Datça 
    Kaptan, Damla. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Anatolia’s agricultural biodiversity, which has evolved with the contributions of many different cultures over thousands of years, is today being rapidly eroded as a result of climate change, population growth, globalization ...
  • A FLY's view of salt inducible kinases: a synergistic tumorigenesis model 
    Sayın, Sercan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The recent explosion of data generated by high-throughput assays on cancer necessitated reliable and fast in vivo models for evaluation new catalogue of candidate genes as tumor suppressors or proto-oncogenes and their ...
  • Transgenic analysis of the Zebrafish OR101-1 gene promoter 
    Söğünmez, Nuray. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The repertoire of olfactory receptors constitutes the largest gene families in humans and in other vertebrates. Typically, olfactory sensory neurons only express a single member of the large genomic repertoire and only one ...
  • Identification and in vivo analysis of putative Wnt target genes with effective roles in cancer 
    Even, İpek. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    One of the most common driving forces in hepatocellular carcinoma (HCC) is the aberrant activation of the Wnt/β-catenin signaling due to the accumulation of mutant β-catenin in the cell. Our group previously detected several ...
  • Possible interactors of alsin and effects of its expression on four motor neuron disease-related proteins 
    Çobanoğlu, Gönenç. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Motor neuron disorders, characterized by selective motor neuron degeneration, consist of a large group of diseases with overlapping genes and common pathological mechanisms. Mutations in ALS2, associated with three types ...
  • Mutation, exome sequencing and linkage analyses in Turkish CMT families 
    Erdoğan, Alperen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Charcot-Marie-Tooth disease (CMT) also known as hereditary motor and sensory neuropathy (HMSN) is the most frequent inherited neuropathy. The patients with CMT generally have distal muscle weakness and atrophy in the ...
  • Development of a drosophila CMT4A model using imago approach 
    Yıldırım, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. So far, approximately 50 genes and loci have been associated with CMT. Mutations in ganglioside-induced differentiation-associated protein ...
  • Genetic factors contributing to ALS in Turkey: ATXN2 polyQ repeat expansions and SNP/CNV associations 
    Ömür, Özgül. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    ALS is the most frequent motor neuron disorder and so far no cure has been developed for this devastating disease. ALS is characterized by the selective loss of both the upper motor neurons of the motor cortex and the lower ...
  • SIK3 involvement in FGF2 signaling in Müller cells 
    Koca, Yıldız. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    FGF2 stimulation of Millier cells regulates several processes including cell proliferation and survival by triggering the activation RaslMAPK and PI3K1 Akt pathways. Data from our lab indicate that serine/threonine kinase ...
  • Elucidating the role of foxo transcription factors on lithium induced growth arrest in hepatocellular carcinoma cells 
    Şekerci, Esra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Lithium is one of the most effective drugs for the treatment of bipolar disorder for years. Many studies have shown that lithium has neuroprotective effect and has acapacity to inhibit cell proliferation. Specifically, it ...
  • Development and molecular analysis of CMT4B1 drosophila model 
    Kılınç, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. Among about 40 genes associated with the disease, MTMR2 loss-of-function mutations are classified as CMT4B1 subtype. ...
  • Genetically accurate models of SOD1-based ALS in drosophila: validation and characterization 
    İskender, Ceren. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    SOD1 has been a unique target of ALS research as the first identified gene of the disease; since 20 years, SOD1 has not been related to any other disease unlike other ALScausing genes. There are more than 160 mutations ...
  • Studying the role of phosphorylation of bacterial protein synthesis elongation factor Tu 
    Kaplan, Uğur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu (EF-Tu) plays a crucial role of carrying aminoacylated-tRNA molecules to the ribosome during the elongation phase of protein synthesis. Being a guanine nucleotide binding protein, EF-Tu is inactive ...
  • Identification of interaction partners of unzipped, a novel cell adhesion molecule 
    Akgün, Gamze. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The brain is unquestionably the most sophisticated organ in bodies of many organisms. Establishment of this complex architecture depends on the ability of axons to find their proper targets. On their way to their synaptic ...
  • Evaluation of exome sequencing data & mutation screening in GDAP1, GJB1, MPZ, NDRG1 and PMP22 genes in Turkish CMT patients 
    Sıvacı, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease which is an inherited peripheral neuropathy is an excellent candidate to be analyzed by exome sequencing because of its locus heterogeneity and low prevalence. Protein-coding regions, ‘the ...