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Yayın tarihi için Moleküler Biyoloji ve Genetik listeleme

Yayın tarihi için Moleküler Biyoloji ve Genetik listeleme

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  • Investigation of motor neuron diseases by wes: genetic dissection of a Turkish ALS cohort 
    Akçimen, Fulya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is characterized by muscle weakness and atrophy due to the degeneration of motor neurons in the motor cortex, brain stem and spinal cord. Both ...
  • Study of the polymerization dynamics of ASC and its domains 
    Kuzucu, Hulusi Onur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Apoptosis-associated speck-like protein containing a CARD (ASC) is a 22 kDa protein composed of two conserved death-fold domains, PYD and CARD, that act as an adaptor protein in in ammasomes, multimolecular complexes that ...
  • Proteomics based search for novel SIK2 substrates involved in endoplasmic reticulum homeostasis 
    Şeker, Tuncay. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    As a result of high calorie diet and low physical activity, obesity has become widespread worldwide in the last two decades. Obesity, which is a risk factor for many diseases including diabetes, hypertension, and fatty ...
  • Transcriptome - wide analysis of iroc target genes in the drosophila olfactory system 
    Taşkıran, İbrahim İhsan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Sensing the environment is vital for an organism and it is provided by divergent sensory neurons. These neurons are generated from sensory organ precursor (SOP) cells that differentiate into neurons with diverse spectral ...
  • Investigating the role of G protein coupled receptor (GPCR) activation in ochratoxin a (OTA)- induced toxicity 
    Aylan, Beren. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Ochratoxin A is recognized as a strong nephrotoxin accumulating and initiating cellular damage in kidney proximal tubule cells. OTA exerts its effects both on cell sur vival and cell death via the deregulation of mitogen ...
  • The molecular landscape of ALS in Turkey: A multifaceted approach to the complex genetics of ALS 
    İskender, Ceren. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease (NDD), characterized by degeneration of both upper and lower motor neurons leading to muscle wasting. With an incidence of two and a prevalence ...
  • Identification on new loci, genes, and mutations responsible for hereditary spastic paraplegia 
    Özeş, Burçak. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Hereditary Spastic Paraplegia (HSP), characterized by lower limb spasticity and progressive weakness, is a group of inherited neurodegenerative disorders. 47 of the 63 genes responsible for HSP, have been associated with ...
  • Investigation of NLRP13 - driven innate immune responses 
    Yılmazer, Açelya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    NOD-like receptors are the key players of inflammasome activation. NLRP13 is a primate specific member of the NLR family containing PYRIN domain and its role in inflammation is still unknown. Since there is no published ...
  • Neuropeptidome and gpcrome of stick insect: Specific structural and functional aspects of allatostatin receptor 
    Duan, Burçin. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    The arthropods constitute about three-quarters of the world’s animal species. The molecules that regulate many physiological events, from the feeding to develop ment, from locomotion to the social behavior, from the ...
  • Investigation of the effects of NF-kB on ota induced apoptosis in HK-2 cell line 
    Gürkaşlar, Can. (Thesis (M.A.) - Bogazici University. Institute for Graduate Studies in the Social Sciences, 2018., 2018.)
    Ocharoxin A (OTA) is a mycotoxin produced by certain species of Aspergillus and Peni cillium genera of fungi. OTA was shown to be carcinogenic, genotoxic, immunotoxic by many studies and main suspected causative agent for ...
  • Clonal analysis of compensatory proliferation in dmHexDC mutants 
    Başdağ, Bilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Recycling of sugar-containing organic compounds (saccharides) have importance for metabolic activity, cellular growth, and differentiation. During this recycling process, many enzymes, primarily lysosomal enzymes, play a ...
  • Functional enrichment methodology for analyzing omics data to study the aetiology of rare diseases 
    Saygı, Ceren. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Rare diseases (RDs) are a large and diverse group of disorders and defined by low prevalence, in other words, it is any disease that affects a small percentage of the population. According to OMIM and Orphanet, ~7000 ...
  • Analysis of positive and negative regulatory sites and their interacting transcription factors in the zebrafish OR101-1 gene promoter 
    Özdemir, Metin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Each olfactory sensory neuron (OSN) of olfactory system expresses a single allele of an olfactory receptor (OR) gene from a large genomic repertoire. How an OSN selects and activates a single OR allele is not well understood ...
  • Is FGF1 acting as a promoter of remyelination in peripheral nervous system? 
    Özkan, Nazmiye. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Bidirectional and continuous communication between Schwann cells (SCs) and axons are crucial for peripheral nervous system (PNS) myelin development, maintenance, and repair after injury. Disruption of SCs-axon interaction ...
  • Disease gene discovery by linkage mapping and exome analysis 
    Bölükbaşı, Esra Yıldız. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Disease gene identification is an important area in genetics. Consanguineous marriages are very common in some populations and lead to emergence of rare diseases. To uncover the functions of our genes and the molecular ...
  • The contribution of purinergic signaling to olfactory neurogenesis in zebrafish 
    Sakızlı, Uğurcan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Compared to other sensory epithelia, the olfactory epithelium (OE) has a remarkably high regenerative capacity: continuous neurogenesis compensates for regular turnover of olfactory sensory neurons (OSNs) while reactive ...
  • Characterization of adipokinetic hormone receptor in stick insect, Carausius Morosus 
    Sınmaz, Merve Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Adipokinetic hormone (AKH) is an insect neuropeptide and known as gonadotropinreleasing hormone, which is orthologue to humans. It is released from corpora cardiaca and acts generally on fat body for energy mobilization. ...
  • Investigation of in vitro and in vivo effects of ochratoxin a on autophagy and ubiquitin - proteasome system 
    Akpınar, Hafıze Ayşin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium genera of fungi and contaminates food and feed. OTA deregulates various signaling pathways and provokes oxidative stress along with augmentation of ...
  • Development of ASC specks as carriers / adjuvants for novel vaccine technology 
    Berber, Mesut. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Pathogen associated molecular patterns (PAMPs) and danger-associated molec ular patterns (DAMPs) are sensed by nucleotide binding oligomerization domain-like receptor (NLR) family of proteins in the cytosol. Certain NLRs ...
  • Mutational analysis of the ARX gene and whole exome sequencing in epileptic encephalopathy patients 
    Özünlü, Hande. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    The term epileptic encephalopathy (EE) is used to describe epileptic syndromes with generally early onset, within the first year of life, refractory to drug treatment and poor developmental outcome. The genetics of epileptic ...