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Yayın tarihi için Moleküler Biyoloji ve Genetik listeleme

Yayın tarihi için Moleküler Biyoloji ve Genetik listeleme

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  • Elucidating the role of unzipped in the visual system of drosophila 
    Terzioğlu Kara, Ece. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    The Drosophila eye is composed of 800 ommatidial units, each containing eight photoreceptors (PR). The outer PRs R1-R6 are responsible for motion detection, while the inner PRs R7 and R8 and are responsible for colour ...
  • Regulation of olfactory receptor gene choice by negative regulatory elements 
    Sancer, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In the olfactory system, each olfactory sensory neuron (OSN) typically expresses only one allele of a single olfactory receptor (OR) gene from a vast genomic repertoire. The mechanisms of OR gene choice, however, are not ...
  • Functional and morphological evaluation of drosophila CMT models 
    Gökerküçük, Elif Begüm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot-Marie-Tooth (CMT) disease is the most frequent inherited peripheral neuropathy in humans with a prevalence of 1 in 2500. It comprises a large group of genetically heterogeneous hereditary motor and sensory neuropathies ...
  • SIK2 functions as a novel tumor suppressor in the breast tumorigenesis 
    Zohrap, Neslihan. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Breast cancer has highly malignant phenotype and is the leading cause of cancer death in women. The heterogenous character of the disease points to the importance of novel target identification for the development of ...
  • Characterization of NLRP13 in inflammasome activity 
    Yalçınkaya, Mustafa. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    NOD-like receptors (NLRs) are a family of cytoplasmic proteins with members regulating inflammation and apoptosis. NLRP13 is a novel PYRIN domain containing NLR family member and the roles of NLRP13 in these pathways is ...
  • Molecular and cellular development of cortical projection neurons: specification, diversity, and directed differentiation from endogenous progenitors for functional circuit repair 
    Özkan, Abdulkadir. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Responsible for perception, integration of sensory information, cognitive function, motor control, and consciousness, the complex, yet highly organized, six-layered mammalian neocortex contains distinct classes of neurons. ...
  • A quest for the upstream activators of ochratoxin a (OTA)- induced MAPK/ERK1/2 
    Gül, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Ochratoxin-A (OTA) is a mycotoxin, produced as a secondary metabolite by fungi belonging to Aspergillus and Penicillium genera. It has been recognized as a carcinogen in rodents and a possible carcinogen to humans. In our ...
  • Characterization of novel Wnt/β-catenin pathway targets 
    Akiva, İzzet. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    The Wnt/β-catenin signaling pathway is an evolutionary conserved pathway which has important functions in vertebrate early development such as axis formation, cellular proliferation and morphogenesis. The activation of ...
  • Negative regulation of Müller reprogramming by SIK2 
    Uğurlu, Aslı. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    In fish it is well known that Müller cells proliferate, gain stem cell characteristics and generate new neurons upon injury. Proliferation is as essential step in retina regeneration and in mammals its tight regulation in ...
  • Implementation of CRISPR based techologies for genome and gene expression maniplation of IRF4 in melanoma cells 
    Yerinde, Cansu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR/Cas9, which was originally characterized as an adaptive immune system in bacteria, has become the most powerful genome engineering technology in recent years ...
  • Neurogenesis and migration of specified chemosensory neurons in the adult zebrafish olfactory epithelium 
    Bayramlı, Khalid. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    In the framework of this study, a systematic and quantitative analysis of the neurogenic process and the integration of adult-born olfactory sensory neurons (OSNs) into the zebrafish olfactory epithelium (OE) was performed. ...
  • Studies on phosphorylation of elongation factor Tu in escherichia coli 
    Kaya, H. Özen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Protein synthesis is a vital process for living organisms. Synthesis of proteins are important for cell survival and reproduction. Protein synthesis takes place on ribosomes in all prokaryotic and eukaryotic cells. Amino ...
  • Investigation of potential ERK-dependent phosphorylation sites on SIK2 
    Taşöz, Emirhan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    The previous studies from our laboratory suggested that the serine/threonine kinase SIK2 is involved in a feedback mechanism downregulating the FGF-dependent MAPK pathway. As it has been shown that the activity of SIK2 is ...
  • In vivo studies of ASC specks as antigen delivery vehicles 
    Yaşa, Seda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    ASC is a 22 kDa adapter protein which is an essential component of the NLRP3, NLRC4 and AIM2 in ammasome complexes. ASC has critical functions in in ammatory and pyroptotic signaling pathways via activating caspase-1. In ...
  • The molecular dissection of ataxias in Turkey and the impact of whole exome sequencing in their precise differential diagnosis 
    Koçoğlu, Cemile. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Ataxias are a diverse group of genetically, clinically and mechanistically heterogeneous neurodegenerative disorders. There is significant overlap in the phenotype of different subtypes of ataxia, which can also manifest ...
  • Pharmacological characterization of the piscf - allatostatin receptor in carausius morosus 
    İşbilir, Ali. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Allatostatins (ASTs) are multifunctional insect neuropeptides that suppress juve-nile hormone (JH) synthesis and feeding behavior. Three different classes of ASTs in in-sects are known as FGLa/ASTs (A-type), MIP/ASTs ...
  • Unzipped mediates axon guidance of drosophila melamosgaster mushroom bodies through neuron-neuron and neuron - glia interactions 
    Çevrim, Bahadır Çağrı. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Drosophila mushroom body (MB) neuropil is the regulatory center for learning, memory, and many different behaviors. Besides its functional role, MB is a great model to investigate axon guidance dynamics. The MB consists ...
  • Aberrant global DNA methylation in neurodegeneration: ALS and trinucleotide repeat disorders 
    Hamzeiy, Hamid. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease of the motor neurons, leading to death within two-three years of onset. Extensive studies have thus far helped identify many genetic causes for ...
  • Determination of genetic diversity of rhododendron species in Turkey 
    Kaya, İsmail Tuğberk. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    The Rhododendrons of Turkey are presented by 10 taxa and they grow naturally along the coast of the Black Sea region from Artvin province at the east to Istranca Mountains at the west. Although in many countries, cultivated ...
  • GJB1 mutation screening and in vitro investigation of its upstream mutations 
    Arı, Oğuz. (Thesis (M.A.) - Bogazici University. Institute for Graduate Studies in the Social Sciences, 2017., 2017.)
    Charcot-Marie-Tooth Type 1X (CMTX1) is the X chromosome linked form of the disease and caused by mutations in the gap junction protein 1 (GJB1) gene. This gene is the second most commonly mutated gene in all CMT forms after ...