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Yayın tarihi için Moleküler Biyoloji ve Genetik listeleme

Yayın tarihi için Moleküler Biyoloji ve Genetik listeleme

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  • Identification of C17ORF45 protein and the effects of its snornas on cell cycle 
    Kapıkıran, Vahap. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The Wnt / β-catenin signaling has many important roles in cellular responses and dysregulation of this pathway are linked to tumor formation. Priorly, SAGE and microarray analyses were performed in our laboratory in order ...
  • Development of a drosophila CMT model via overexpression and knocking-in of GDAP1 gene 
    Akyüz, Hüseyin Kaya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Charcot-Marie-Tooth (CMT) disease is one of the most common inherited disorders of the nervous system. Known also as hereditary motor and sensory neuropathy, this disease is characterized by distal sensory loss, muscle ...
  • Characterization of IRF4 dependency in melanoma cell lines 
    Ayhan, Mustafa Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Interferon Regulatory Factor 4 (IRF4, also known as MUM1, LSIRF, NFEM5, and ICSAT) is a transcription factor with important regulatory roles on B-cell matura-tion and differentiation. Although the first identification of ...
  • Characterization of a novel R7-specific gene in the drosophila visual system 
    Kaçmaz, Güner. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The proper functioning of the nervous system depends on the correct specification of many different cell types and the establishment of proper connections between neurons during development. The visual system of Drosophila ...
  • Structural aspects of ASC speck formation and its potential novel functions 
    Sahillioğlu, Ali Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
  • The functional role of ASP50 in protein synthesis elongation factor Tu 
    Baş, Levent. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Elongation factor Tu is an essential enzyme responsible for delivering aminoacyltRNA's to ribosomal A-site during protein synthesis. In its active GTP-bound state, it forms an EF-Tu · GTP · aminoacyl-tRNA ternary complex ...
  • Mammalian enabled (MENA): a possible regulator of yap oncoprotein 
    Karaman, Ruçhan (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Mammalian Enabled (Mena) induces unbranched actin polymerization and it acts as an antagonist for actin capping proteins in the cell. As an actin related protein, Mena has an important role on both tumor initiation and ...
  • Identification of novel genes involved in planar cell polarity establishment in the Drosophila eye 
    Koldere, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    In multicellular organisms proper functioning of tissues requires precise patterning of cells, which is acquired by apical-basal and planar cell polarization. To establish planar cell polarity (PCP), cells have to organize ...
  • Disease gene search via linkage mapping and exome sequencing 
    Köroğlu Altok, Çiğdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of disease genes has a key importance in understanding the molecular mechanisms of disease pathogenesis as well as in expanding our knowledge on gene function. Linkage mapping is a powerful method to identify ...
  • The myelination puzzle: do fibroblast growth factors and their receptors have regulatory roles in peripheral nerve myelination? 
    Dağlıkoca, Emine Duygu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Axon-Schwann cell interaction is the key step in myelination and critical in the pathogenesis of peripheral neuropathies. Molecules mediating this interaction to promote the complex mechanism of myelination have not been ...
  • Involvement of autophagy in ochratoxin-a (OTA) -mediated toxicity in HK-2 cell line 
    Kahraman, Hilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Ochratoxin A (OTA) is a secondary metabolite produced by fungi and found in a variety of food and feed. It is classi ed as a possible human carcinogen and immense amount of work has revealed to its nephrotoxic and carcinogenic ...
  • Functional analysis of a splice site mutation in BABRG2 gene and its effect on GABAA receptor 
    Kaplan, Öyküm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Epilepsy is a group of diseases produced by non-controlled discharge of neurons affecting more than 2% of the population and some forms include genetic determinants. The principal group of inherited epilepsy is Genetic ...
  • Characterization and regulation of human Kim-1 gene promoter the role of activator protein 1 (AP1) transchiption factor 
    Bergin, Tijen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Kidney Injury Molecule-1 (KIM-1) is an immunoglobulin superfamily cell surface protein highly upregulated on the surface of dedifferentiated renal proximal tubule epithelial cells regenerating after toxic or ischemic injury. ...
  • Functional study of certain genes selected from SSH library of common bean under salinity stress 
    Canher, Balkan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Considering that one third of Earth’s arable lands are affected by soil salinity, understanding how plants respond to salinity stress and creation of stress tolerant crops is of outmost importance. Phaseolus vulgaris (common ...
  • Linkage and exome sequence analyses to identify disease genes 
    Ayhan, Özgecan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Identification of the genetic basis of a hereditary disease provides important information about the molecular mechanism of the disease and the function of the gene and could contribute to the development of therapeutic ...
  • Translational regulation of Kidney Injury Molecule-1 MRNA: presence of an internal ribosomal entry site 
    Banaz, Nehir. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Kidney Injury Molecule-1 (KIM-1) is a type I transmembrane glycoprotein that is highly upregulated on regenerating dedi erentiated renal proximal tubular epithelial cells as a consequence of toxic or ischemic injury. KIM-1 ...
  • Characterization of Interferon Regulatory Factor 4 (IRF4) target genes in melanoma cell lines 
    Yılmaz, Erdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    IRF4 is a critical transcription factor in the development and function of immune cells, and additionally, it is deregulated in certain myeloid and lymphoid malignancies. Un-til recently, IRF4 expression was thought to be ...
  • Regulation of human BFK 
    Uğurlu, Serkan. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Bcl-2 protein family members are critical regulators for apoptosis. Reduced levels of apoptotic Bcl-2 family members are detected in gastrointestinal cancers which are responsible for a considerable part of the deaths from ...
  • Validation of the OR103-1/5 intergenic sequence as a molecular tool to promote bi-cistronic translation in zebrafish 
    Uzel, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Sensory neuron in the olfactory system, typically expresses only a single olfactory receptor (OR) gene from a large and diverse genomic repertoire. In zebrafish, a violation of this ‘one neuron – one receptor rule’ has ...
  • The role of unzipped axon guidance and targeting in the olfactory system of drosophila melanogaster 
    Mika, Kaan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    The olfactory system of Drosophila is a great model to investigate neural wiring complexity. The fly has two sensory appendages named as antenna and maxillary palp. Hair-like structures called as sensilla cover the appendages ...