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Browsing Kimya Mühendisliği by Subject "Cellular signal transduction."

Browsing Kimya Mühendisliği by Subject "Cellular signal transduction."

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  • Effectsof rapamycin and caffeine on TOR signaling pathway in Saccharomyces cerevisiae 
    Kuzu, Güray. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The aim of this study is to understand the effect of caffeine and rapamycin on the growth of yeast cells and identify flux changes in the presence of these chemicals in yeast. The repression effect of different concentrations ...
  • Game theoric analysis of MAPK signaling pathways in Saccharomyces cerevisiae 
    Çavlı, Can. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)
    Understanding cellular signaling is central for gaining insight into the molecular mechanisms behind diseases as well as adaptation of living cells to changes in the environment. Signaling pathways are often branched in ...
  • Identification of allosteric AKT inhibitors by computational methods 
    Gürsoy Yılmaz, Oya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    AKT kinases are known to be major contributors to the development of many human cancers according to preclinical data and studies of tumor specimens. Design and development of small molecule inhibitors targeting AKT and ...
  • Investigation of noncanonical Wnt signaling network in C. elegans 
    Alazi, Feras. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Wnt proteins, a well conserved family of signalling molecules, initiate signalling mechanisms that play important roles in embryonic development of animals. Wnt proteins activate three distinct signalling pathways. ...
  • Reconstruction of protein-protein and domain-domain interaction networks of WNT signaling in C. elegans 
    Oruç, Muhammed Enes. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Signaling pathways and gene expression play an important role in living organisms during adult homeostasis. It is important how to behave against the changes in gene expression that is resulted in diseases due to signaling ...
  • Recontruction of insulin signaling network in H. sapiens 
    Ümit, Pelin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Insulin is an animal hormone that regulates the glucose levels in blood. It is medically used to treat diabetic patients. Diabetes is characterized by the failure of synthesizing, secreting or responding to insulin and it ...
  • Structural analysis of epidermal growth factor receptor and yeast signaling networks 
    Tekir, Saliha Durmuş. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)
    The recent progress in high-throughput technologies is allowing the reconstruction of large-scale models of signaling networks and development of corresponding analysis methods. Network properties of the most comprehensive ...
  • Structural analysis of mammalian toll-like receptor signaling network 
    Özbabacan, Saliha Ece Acuner. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Comprehensive maps of large-scale signaling networks are attractive for researchers interested in signal transduction mechanisms because the information they give can be used as a basis for mathematical interpretations ...
  • Studies on the genes controlling glucose signaling in yeast 
    Şanoviç, Aylin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    This project was aimed to study the phosphorylation or dephosphorylation of the proteins involved in glucose sensing, signal transduction and glucose repression pathways by transcription of genes encoding these proteins. ...
  • System biology of yeast signal transduction 
    Arğa, Kazım Yalçın. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)
    Reconstruction of protein interaction networks that represent groups of proteins contributing to the same cellular function is a key step towards quantitative studies of signal transduction pathways. In the present study, ...
  • Virtual screening and docking of potential protein kinase B inhibitors 
    Kenar, Seval. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    This study aims to carry out a molecular docking process of novel ATP competitive inhibitors for protein kinase B-beta (PKBβ / AKT-2), activation of which has been observed in 30-40% of ovarian and pancreatic cancers. 3D ...

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