Eren, Dilek.
(Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
Protein tyrosine phosphatase 1B (PTP1B) plays a key role as negative regulator of insulin and leptin signaling. In human PTP1B, a significant conformation change is seen in the WPD loop from open (inactive) to closed ...