Özkaral, Burcu.
(Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin and leptin signaling, and is a major molecular target for the treatment of type II diabetes and obesity. WPD loop is a key element in the mechanism ...