Browsing Kimya Mühendisliği by Title

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  • Investigation of bacterial infection strategies through bacteria-human protein-protein interactions by bioinformatics approaches 
    Gürses, Büşra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Infectious diseases, which have been a serious threat for human life in ancient times, is still leading the causes of death and disability worldwide. Pathogens (viruses, bacteria, protozoa, fungi, etc.) express a wide range ...
  • Investigation of beta-lactamase ligand binding in vivo and in silico 
    Kanlıkılıçer, Pınar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    β-lactam antibiotics are the most commonly used antibiotics due to their high effectiveness, low cost, ease of delivery and minimal side effects. Bacteria have acquired resistance to these antibiotics. One of the mechanisms ...
  • Investigation of cell cycle network of yeast using lab-on-a-chip platform 
    Odabaşı, İrem Ezgi. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Genome instability has long been implicated as a salient causal factor in aging and age related diseases such as cancer and neurodegeneration. However, the molecular mechanisms associated with genome instability remain ...
  • Investigation of CO hydrogenation catalysts for direct synthesis of dimethyl ether 
    Ekmen, Çiğdem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    The aim of this work was to prepare and test bi-functional direct DME synthesis catalysts, including commercial ones, involving methanol synthesis and methanol dehydration functions. Catalyst beds were prepared by physical ...
  • Investigation of CO hydrogenation catalysts for producing oxygenated hydrocarbons 
    Kabakçı, Didem Büşra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    The objective of this study was to test the performance of promoted rhodium catalysts supported on silica for oxygenated hydrocarbon (particularly ethanol) production by CO hydrogenation. Two different catalysts were ...
  • Investigation of CO oxidation kinetics over gold catalysts 
    Ülgüel, Caner. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    This experimental study involves preliminary work conducted over 0.5wt%Au/Al2O3 and kinetic study of low-temperature CO oxidation over 1wt%Au/1.25-wt%MgO/Al2O3 prepared by the homogeneous deposition-precipitation method. ...
  • Investigation of conformational fluctuations in protein dynamics: torsional Gaussian Network Model 
    Özbakır, Harun Ferit. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Elastic network models based on Normal Mode Analysis (NMA) are very useful in determining the conformational fluctuations that would affect the functions of proteins. Gaussian Network Model (GNM) is proved to be a very ...
  • Investigation of coupling between collective dynamics and function of enzymes 
    Kocaman, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    To bridge the structure and function of an enzyme through dynamics is an important problem in protein science. For this aim, the vibrational dynamics for a set of enzymes with different biological units and fold types are ...
  • Investigation of crosstalk between Wnt and Hedgehog signaling pathways 
    Eren, Aysun. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    In the last few years, an intense interest is being shown in the evolutionarily conserved signaling pathways which have crucial roles during embryonic development. The most intriguing factor behind this interest is that ...
  • Investigation of dynamic allostery in motor proteins 
    Kaya, Cihan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    Allostery is a key concept in regulation of protein function. The communication pathways which are equivalent of the allosteric signaling or energy propagation pathways are the most significant aspect of allosteric mechanism. ...
  • Investigation of effects of neurological diseases on human brain metabolism: computational systems biology approach 
    Sertbaş, Mustafa. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    The objective of this study is the investigation of the effects of Parkinson’s disease on human brain metabolism by using computational systems biology approach. A new brain metabolic model originated from Çakır et al., ...
  • Investigation of in-vivo inhibition of β-lactamase by β-lactamase inhibitor protein 
    Akkaya, Ayşe Ezgi. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    β-lactam antibiotics, which target transpeptidase enzymes that synthesize the bacterial cell wall, are the most widely utilized antimicrobial agents. However owing to the widespread usage, bacteria acquire resistance to ...
  • Investigation of infection mechanisms through pathogen-human protein-protein interactions by bioinformatics approaches 
    Tekir, Saliha Durmuş. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Social Sciences, 2013., 2013.)
    Since ancient times, even in today's modern world, infectious diseases cause lots of people to die. The interactions between the proteins of infectious microorganisms, pathogens and their human hosts allow the microorganisms ...
  • Investigation of linear paths in human wnt signaling network 
    Nalbantoğlu, Bahar. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Recently, the evolutionarily conserved signaling pathways which are involved in embryonic development are on the march for many research since the deregulations seen in the mechanism of these patways results in several ...
  • Investigation of medulloblastoma metabolism by tissue-specific genome-scale brain metabolic model and identification of therapeutic targets 
    Özbek, İlkay İrem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Medulloblastoma (MB) is the most prevalent pediatric brain tumor arising in the cerebellum. Since conventional therapies decrease life quality and cause deleterious effects on children, computer models are urgently ...
  • Investigation of noncanonical Wnt signaling network in C. elegans 
    Alazi, Feras. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Wnt proteins, a well conserved family of signalling molecules, initiate signalling mechanisms that play important roles in embryonic development of animals. Wnt proteins activate three distinct signalling pathways. ...
  • Investigation of novel pharmacological chaperones against gaucher disease 
    Yılmazer, Büge. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Beta-Glucocerebrosidase (GBA) is a lysosomal protein which is responsible for the hydrolysis of glycosylceramide into glucose and ceramide. Mutations in GBA cause a dramatic decrease in activity and lead to accumulation ...
  • Investigation of PTP1B activation mechanism computational methods 
    Özkaral, Burcu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin and leptin signaling, and is a major molecular target for the treatment of type II diabetes and obesity. WPD loop is a key element in the mechanism ...
  • Investigation of the bacterial uptake of fluorescently labeled peptides and motility studies using lab-on-a-chip technology 
    Yüce, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Bacterial resistance in pathogens is a worldwide challenge associated with high mortality. The aim was to use microfluidic technology for two different applications in the fight with bacterial resistance. In the first part ...
  • Investigation of the effect of plasticity on the prediction of genetic interactions and phenotypes in Saccharomyces Cerevisiae 
    Dikicioğlu, Duygu. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Prediction of phenotype from genome-scale high-throughput network and component information still remains a challenge for systems based approaches in biological research. The enhancement of our power of prediction of ...

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