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Browsing Kimya Mühendisliği by Author "Özkırımlı, Elif."

Browsing Kimya Mühendisliği by Author "Özkırımlı, Elif."

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  • Bacterial uptake of antimicrobial peptides 
    Irvalı, Deniz. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    The discovery of beta lactam antibiotics has been a groundbreaking improvement in the treatment of bacterial diseases. However, most bacteria have gained resistance against beta lactam antibiotics which rendered them ine ...
  • Beta-lactamase binding to blip and blip based peptides 
    Doğan, Aslıgül. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Extensive use of antimicrobial agents has generated selective pressure on bacteria and resulted in development of resistance to beta-lactam antibiotics. The main resistance mechanism of bacteria is the production of ...
  • Beta-lactamase ligand recognition 
    Menekşedağ, Deniz. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Beta-lactamases hydrolyze the beta-lactam ring of antibiotics, rendering them ineffective. Understanding the inhibitor recognition mechanism of beta-lactamases will give important information toward the fight against ...
  • Cloning and expression of TagI restriction endonuclease gene using pMAL-c2 vector system in different strains of escherichia coli 
    Özkırımlı, Elif. (Thesis (M.S.) - Bogazici University.Institute for Graduate Studies in Science and Engineering, 1998., 1998.)
    The thermostable TaqI restriction endonuclease from Thermus aquaticus was cloned into Escherichia coli for overproduction and single step affinity chromatography purification. The gene was cloned into pMAL-c2 vector, ...
  • Computational prediction of protein-protein interactions in sphingolipid signaling network 
    Güngörmez, Yasemen. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    Proteins carry out most of the work in the cell such as immunological recognition, DNA repair and replication, enzymatic activity, cell signaling by interacting with other proteins. Therefore deciphering protein-protein ...
  • Drug design against antimicrobial resistance 
    Kalyon, Kevser Betül. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Cell penetrating peptides are extensively studied due to their potential for having antimicrobial properties. The purpose of this study is to understand the mechanisms of certain cell penetrating peptides in bacterial and ...
  • Effect of simultaneous beta-lactamase inhibitor protein expression on cellular beta-lactamase activity 
    Yalaz, Kadriye Simay. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    β-lactam antibiotics are commonly used in the treatment of bacterial infections. However, due to underuse and misuse of β-lactam antibiotics, bacteria have developed mechanisms that counteract β-lactam antibiotics. The ...
  • Effectsof rapamycin and caffeine on TOR signaling pathway in Saccharomyces cerevisiae 
    Kuzu, Güray. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The aim of this study is to understand the effect of caffeine and rapamycin on the growth of yeast cells and identify flux changes in the presence of these chemicals in yeast. The repression effect of different concentrations ...
  • Functional analysis of the genes in the glucose metabolic network by a system based modular approach 
    Yüzüak, Okan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    In this study, all proteins associated with the Process Gene Ontology (GO) term “Glucose Metabolic Process” were collected and a network of all reported interactions among these entities was constructed with a stringent ...
  • Identification of allosteric AKT inhibitors by computational methods 
    Gürsoy Yılmaz, Oya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    AKT kinases are known to be major contributors to the development of many human cancers according to preclinical data and studies of tumor specimens. Design and development of small molecule inhibitors targeting AKT and ...
  • Identification of drug targets towards prostate canser 
    Esvap, Elif. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Prostate cancer (Pca) is one of the leading cause of cancer deaths and second common cancer type in men. Identifying novel diagnostics and drug targets specific for Pca is critical since early detection and treatment are ...
  • Identification of TPX inhibitors against pathogen-host interactions 
    Deniz, Utku. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Antibiotic resistance is a major health issue as due to the emergence of multidrug resistant bacteria. Thus, there is an increasing need for the identification of new drug targets and discovery of novel scaffolds in the ...
  • In silico analysis of neutral sphingomyelinase 2 
    Yağcı, Zarife Begüm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Neutral sphingomyelinase 2 (nSMase2) is an important sphingolipid metabolism enzyme that generates ceramide through the hydrolysis of sphingomyelin (SM) present in the plasma membrane. It has been suggested as a therapeutic ...
  • Investigation of beta-lactamase ligand binding in vivo and in silico 
    Kanlıkılıçer, Pınar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    β-lactam antibiotics are the most commonly used antibiotics due to their high effectiveness, low cost, ease of delivery and minimal side effects. Bacteria have acquired resistance to these antibiotics. One of the mechanisms ...
  • Investigation of in-vivo inhibition of β-lactamase by β-lactamase inhibitor protein 
    Akkaya, Ayşe Ezgi. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    β-lactam antibiotics, which target transpeptidase enzymes that synthesize the bacterial cell wall, are the most widely utilized antimicrobial agents. However owing to the widespread usage, bacteria acquire resistance to ...
  • Investigation of novel pharmacological chaperones against gaucher disease 
    Yılmazer, Büge. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Beta-Glucocerebrosidase (GBA) is a lysosomal protein which is responsible for the hydrolysis of glycosylceramide into glucose and ceramide. Mutations in GBA cause a dramatic decrease in activity and lead to accumulation ...
  • Investigation of PTP1B activation mechanism computational methods 
    Özkaral, Burcu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin and leptin signaling, and is a major molecular target for the treatment of type II diabetes and obesity. WPD loop is a key element in the mechanism ...
  • Investigation of the bacterial uptake of fluorescently labeled peptides and motility studies using lab-on-a-chip technology 
    Yüce, Merve. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Bacterial resistance in pathogens is a worldwide challenge associated with high mortality. The aim was to use microfluidic technology for two different applications in the fight with bacterial resistance. In the first part ...
  • Peptide drugs against antibiotic resistant bacteria 
    Alaybeyoğlu, Begüm. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Membrane active peptides have found great interest as drug candidates due to their unique mode of action and availability in nature. In the past 20 years, beta lactamase-mediated antibiotic resistance has become a lethal ...
  • Pharmacological chaperone search for arylsulfatase a enzyme (ARSA) and characterization of two novel mutations 
    Eren, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Arylsulfatase A (ARSA) is an important lysosomal enzyme whose deficiency due to misfolding or oligomerization loss causes a lethal neurodegenerative disease called Metachromatic Leukodystrophy Disease (MLD). This is an ...

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