Antibodies are large molecular weight proteins produced by the immune system. They have high affinity to receptors on different cells’ surfaces. Using this affinity, a number of studies have been conducted to deliver ...

In the first part of this dissertation, computer-aided drug design approaches, structurebased methodologies such as docking, molecular dynamics simulations and Gibbs free energy calculations with Molecular Mechanics-Generalized ...

Nonracemic axially chiral thiohydantoins were synthesized atroposelectively by the reaction of ortho-arylisothiocyanates with amino acid ester salts in the presence of triethylamine (TEA). However, the synthesis of the ...

In this study, 5,5-dimethyl-1-(0-aryl)barbituricI, 1-(0-ary1)barbituric and 1-(0-aryi)- 2-thiobarbituric acids have been synthesized by the reaction of the o-arylureas or the oaryl- 2-thioureas with the diethylmalonate or ...

This work describes synthesis, characterization, and evaluation of (bis)phosphonate functionalized monomers, macromers and crosslinkers as well as their polymers and crosslinked networks for biomedical applications such ...

Hydrogels have attracted remarkable attention since they have high potential uses in many fields. They are commonly used in tissue engineering, drug delivery systems, biosensors and wound healing dressings. Recently, there ...

This study focused on structural and photocatalytic properties of TiO2 incorporated Sepiolite and Na-Montmorillonite. Catalyst characterization was carried out by thermal gravimetric analysis (TGA), X-ray diffraction (XRD), ...

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One of the important issues in drug design is the identification of the biological activity of receptor ligands. Development, synthesis and activity measurements of ligands have a major importance in drug design. However, ...

The present study is concerned with the application of the Molecular Mechanics Method to 2-substituted cyclohexanoneketals. The object is to find the conformational free energy difference between the equilibrating conformers ...