Fen Bilimleri Enstitüsü: Recent submissions

  • Characterization of GPR139 and investigating its possible role in brain development 
    Aslan, Tolga. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    G protein coupled receptors are a large family of cell surface receptors and are involved in a plethora of physiological functions from vision to various neuronal func tions. They have been a major target in the pharmaceutical ...
  • Investigation of the effects of SUMO modification on two critical proteins : a pathogenic NEK1 mutant that drives ALS pathogenesis and the CRISPR-associated CAS9 protein 
    Ergünay, Tunahan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Small Ubiquitin-like modifier (SUMO) is an essential eukaryotic post-translational modification. SUMO isoforms attach to specific lysine residues on target substrates to modi-fy their function, activity, solubility and ...
  • Dissecting the crosstalk between inhibitory receptor signaling and the T cell receptor in natural killer cells 
    Ergün, Ebru Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Killer-cell immunoglobulin-like receptors (KIRs) are among the most prominent receptors regulating NK cell development and function. Most KIR ligands are the MHC class I molecules found on target cells. KIRs are responsible ...
  • Co-receptor mediated regulation of T cell receptor signalling in natural killer cells 
    Karahan, Zeynep Sena. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Antigen-specific cancer immunotherapy has been developing since the 1990s and showing promising results. T cell receptors (TCR) and Chimeric antigen receptors (CAR) are the most commonly used tools for modifying T cells ...
  • Further characterization of heart - and skeletal muscle-specific mitochondrial aspartyle -tRNA synthetase (DARS2) knockout mouse 
    Kartal, Özlem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Mitochondrial respiratory chain defects are the primary cause of mitochondrial disorders. Mitochondria have developed various adaptive responses to counteract the effects of these defects. In this study, the heart- and ...
  • The role of MAPK and AKT signaling during zebrafish olfactory epithelium regeneration 
    Dokuzluoğlu, Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The zebrafish olfactory epithelium (OE) is a neuroepithelium that is able to re generate neurons. The ability of the OE for neuron regeneration stems from the pres ence of a dual progenitor system that persists to the ...
  • Identification of HB-EGF positive and HB-EGF responsive cell populations in zebrafish olfactory epithelium 
    Güler, Kardelen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The peripheral olfactory epithelium (OE) is an exception to the limited capacity of the adult nervous system to undergo neurogenesis, which supports structural repair in response to traumatic injury. It continuously and ...
  • Investigation of NLRP13's cleavage and its role in macrophage polarization 
    Çıracı, Sevgi. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The NOD-like receptors (NLRs) are mainly known for their roles in inflamma tory responses and host defense against microbial pathogens, but they are also asso ciated with metabolic disorders, autophagy regulation, transcription ...
  • Characterization of CkIIα-i1 -a putative ortholog of intellectual disability candidate gene ZBTB11 
    Mandacı, Barış Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Intellectual Disability (ID) is a heterogenic neurodevelopmental disorder seen in different spectrums in affected individuals. Resulting problems in the diagnosis of ID and limitations in its treatment constitutes a great ...
  • Identification of allosteric binding sites of the allatostatin receptor type-C of pine processionary moth 
    Kahveci, Kübra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    G-protein coupled receptors (GPCRs) are cell surface receptors that are consisted of seven-transmembrane α helices. Drugs targeting GPCRs account for one-third of clinically approved drugs; since many drugs target the ...
  • Investigation of the effects of ochratoxin-a on global protein sumoylation 
    Denizli, İrem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Ochratoxin A (OTA), a secondary metabolite produced by especially Aspergillus and Penicillium species, is found as a contaminant in foods such as daily consumed corn flakes, coffee, meat and dairy products. OTA is a potential ...
  • The role of EGFR and JAK 
    Alkiraz, Aysu Şevval. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The zebrafish olfactory epithelium (OE) has an exceptional neurogenic capacity, which supports the continuous turnover olfactory sensory neurons (OSNs) and efficient regeneration after injury. These processes depend on the ...
  • Characterization of the E3 ubiquitin ligase RNFT2 ortholog CG13605 in drosophila melanogaster 
    Kahraman, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Characterized by deficits in both intellectual ability and adaptive behavior, intellectual disabilities (IDs) are one of the major neurodevelopmental disorders with a prevalence of 1- 3% worldwide. Development of Next ...
  • Investigation of the impact of human immunodeficiency virus on cellular sumoylation 
    Pekbilir, Emre. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The manifestation of Human Immunodeficiency Virus type 1 (HIV-1) infection is acquired immunodeficiency syndrome (AIDS), one of the major health problems worldwide. From the first step of infection to the end, HIV-1 ...
  • Preliminary characterization of a novel mitochondrial myopathy mouse model 
    Yılmaz, Mehmet. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Mitochondria provide a significant portion of the ATP to cells and govern cellu lar energy economics on ever-changing cellular energy requirements. Cells evolved to monitor mitochondrial stress and developed counteracting ...
  • Smoothing properties of initial-boundary value problems 
    Başakoğlu, Engin. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    This thesis discusses the smoothing properties of dispersive partial differential equations. In the first part of the thesis, we consider the Davey–Stewartson system on R 2 and demonstrate that the nonlinear part of the ...
  • Simple section biset functors 
    Muslumov, Ruslan. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Let G and H be finite groups and k be a commutative unitary ring. The Burnside group B(G,H) is the Grothendieck group of the category of finite (G,H)-bisets. The biset category kC of finite groups is the category defined ...
  • Kadison-Singer problem from a banach algebra perspective 
    Keçkin, Murat. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    In 1959, Kadison and Singer asked whether every pure state of the diagonal subspace D(ℓ2) of B(ℓ2) has a unique pure state extension to B(ℓ2). This problem has remained open until 2013; in 2013 it has been solved by a team ...
  • Theory of noncommutative motives 
    Üze, Berkan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The theory of motives was originally conceived by Alexander Grothendieck as a universal cohomology theory for algebraic varieties. In the decades since it was first introduced, it has become a vast and profoundly sophisticated ...
  • Monogenic number fields 
    Değirmenci, Pınar. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Determining whether the ring of integers OK of an algebraic number field K of degree n admits a power integral basis is one of the classic problems in algebraic number theory. In other words, we want to determine whether ...