Arşiv ve Dokümantasyon Merkezi
Dijital Arşivi

Başlık için Fen Bilimleri Enstitüsü listeleme

Başlık için Fen Bilimleri Enstitüsü listeleme

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  • Investigation of homotypic PYD and CARD domain interactions in ASC speck assembly 
    Otaş, Hasan Ozan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Apoptosis-associated speck-like protein containing a CARD (ASC) is a 22 kDa protein containing conserved PYD and CARD domains that belong to death-fold superfamily. Homotypic interactions between the domains occur via ...
  • Investigation of in vitro and in vivo effects of ochratoxin a on autophagy and ubiquitin - proteasome system 
    Akpınar, Hafıze Ayşin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium genera of fungi and contaminates food and feed. OTA deregulates various signaling pathways and provokes oxidative stress along with augmentation of ...
  • Investigation of in-vivo inhibition of β-lactamase by β-lactamase inhibitor protein 
    Akkaya, Ayşe Ezgi. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)
    β-lactam antibiotics, which target transpeptidase enzymes that synthesize the bacterial cell wall, are the most widely utilized antimicrobial agents. However owing to the widespread usage, bacteria acquire resistance to ...
  • Investigation of infection mechanisms through pathogen-human protein-protein interactions by bioinformatics approaches 
    Tekir, Saliha Durmuş. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Social Sciences, 2013., 2013.)
    Since ancient times, even in today's modern world, infectious diseases cause lots of people to die. The interactions between the proteins of infectious microorganisms, pathogens and their human hosts allow the microorganisms ...
  • Investigation of interaction energies of topoisomerase I inhibitor: topotecan 
    Dikmenli, Ayşe Kumru. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Topoisomerases (Top1) cut one or both strands of DNA and therefore bring changes in the topology of DNA. They are ubiquitous enzymes which are essential for the cellular regulation of DNA supercoiling caused by processes ...
  • Investigation of interaction partners of NLRP13 
    Ok, Hilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    NOD-like receptors (NLRs) are the cytoplasmic members of pattern recognition receptor family, broadly with functions in inflammasome formation, signal transduction, transcription activation, cell death, reproduction, and ...
  • Investigation of IRF4-MEF2D protein-protein interaction in melanoma cells 
    Hedaya, Laila Samir Abed. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    Cancer is a leading cause of death worldwide. Protein-protein interactions (PPIs) constitute a fundamental unit of the oncogenic signaling pathways that stimulate survival, growth and proliferation of cancer cells. Therefore, ...
  • Investigation of linear paths in human wnt signaling network 
    Nalbantoğlu, Bahar. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Recently, the evolutionarily conserved signaling pathways which are involved in embryonic development are on the march for many research since the deregulations seen in the mechanism of these patways results in several ...
  • Investigation of medulloblastoma metabolism by tissue-specific genome-scale brain metabolic model and identification of therapeutic targets 
    Özbek, İlkay İrem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    Medulloblastoma (MB) is the most prevalent pediatric brain tumor arising in the cerebellum. Since conventional therapies decrease life quality and cause deleterious effects on children, computer models are urgently ...
  • Investigation of molecular signals regulating cell proliferation and neurogenesis in the intact and injured Zebrafish (Danio rerio) olfactory epithelium 
    Demirler, Mehmet Can. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    The zebrafish olfactory epithelium (OE) can recover from the near total loss of olfactory sensory neurons (OSNs) within only a week when the OE is damaged by external causes. This remarkable neurogenic activity depends ...
  • Investigation of motor neuron diseases by wes: genetic dissection of a Turkish ALS cohort 
    Akçimen, Fulya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is characterized by muscle weakness and atrophy due to the degeneration of motor neurons in the motor cortex, brain stem and spinal cord. Both ...
  • Investigation of NLRP13 - driven innate immune responses 
    Yılmazer, Açelya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    NOD-like receptors are the key players of inflammasome activation. NLRP13 is a primate specific member of the NLR family containing PYRIN domain and its role in inflammation is still unknown. Since there is no published ...
  • Investigation of NLRP13's cleavage and its role in macrophage polarization 
    Çıracı, Sevgi. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The NOD-like receptors (NLRs) are mainly known for their roles in inflamma tory responses and host defense against microbial pathogens, but they are also asso ciated with metabolic disorders, autophagy regulation, transcription ...
  • Investigation of noncanonical Wnt signaling network in C. elegans 
    Alazi, Feras. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Wnt proteins, a well conserved family of signalling molecules, initiate signalling mechanisms that play important roles in embryonic development of animals. Wnt proteins activate three distinct signalling pathways. ...
  • Investigation of novel pharmacological chaperones against gaucher disease 
    Yılmazer, Büge. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Beta-Glucocerebrosidase (GBA) is a lysosomal protein which is responsible for the hydrolysis of glycosylceramide into glucose and ceramide. Mutations in GBA cause a dramatic decrease in activity and lead to accumulation ...
  • Investigation of novel recessive causative genes and gene / allele frequency for CMT disease in Turkey 
    Candayan, Ayşe. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    Inherited peripheral neuropathies are a group of genetic disorders of the periph eral nervous system. The most common type is called Charcot-Marie-Tooth (CMT) disease that constitutes an interesting research focus due to ...
  • Investigation of optimal cam profiles by dynamic optimization 
    Mutlu, Ernur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1982., 1982.)
    In this study an investigation to find the optimal profiles for automotive cam systems has been made. The method of dynamic optimization is utilized in this objective. To formulate the problem various factors that affect ...
  • Investigation of polyethylene terephthalate synthesis via solution polymerization technique 
    Yeşil, Işıl. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Poly (ethylene terephthalate) (PET) is a thermoplastic polyester commonly used in the industry owing to its good mechanical strength, thermal stability, high solvent resistance and low-cost production. According to application ...
  • Investigation of potential ERK-dependent phosphorylation sites on SIK2 
    Taşöz, Emirhan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    The previous studies from our laboratory suggested that the serine/threonine kinase SIK2 is involved in a feedback mechanism downregulating the FGF-dependent MAPK pathway. As it has been shown that the activity of SIK2 is ...
  • Investigation of preservice mathematics teachers' algebraic thinking through translations among multiple representations 
    Pehlivan, Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    The objective of this explanatory study was to gain insight into thinking pro cess of preservice secondary school mathematics teachers as they approached problems that required for translations from graphical representations ...