Boğaziçi Üniversitesi Tezleri: Recent submissions

  • A quest for the upstream activators of ochratoxin a (OTA)- induced MAPK/ERK1/2 
    Gül, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Ochratoxin-A (OTA) is a mycotoxin, produced as a secondary metabolite by fungi belonging to Aspergillus and Penicillium genera. It has been recognized as a carcinogen in rodents and a possible carcinogen to humans. In our ...
  • Investigation of potential ERK-dependent phosphorylation sites on SIK2 
    Taşöz, Emirhan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    The previous studies from our laboratory suggested that the serine/threonine kinase SIK2 is involved in a feedback mechanism downregulating the FGF-dependent MAPK pathway. As it has been shown that the activity of SIK2 is ...
  • In vivo studies of ASC specks as antigen delivery vehicles 
    Yaşa, Seda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    ASC is a 22 kDa adapter protein which is an essential component of the NLRP3, NLRC4 and AIM2 in ammasome complexes. ASC has critical functions in in ammatory and pyroptotic signaling pathways via activating caspase-1. In ...
  • Pharmacological characterization of the piscf - allatostatin receptor in carausius morosus 
    İşbilir, Ali. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Allatostatins (ASTs) are multifunctional insect neuropeptides that suppress juve-nile hormone (JH) synthesis and feeding behavior. Three different classes of ASTs in in-sects are known as FGLa/ASTs (A-type), MIP/ASTs ...
  • Aberrant global DNA methylation in neurodegeneration: ALS and trinucleotide repeat disorders 
    Hamzeiy, Hamid. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease of the motor neurons, leading to death within two-three years of onset. Extensive studies have thus far helped identify many genetic causes for ...
  • NLRC3: a new player at the crossroads of inflammasome regulation, cell proliferation and immune tolerance 
    Eren, Elif. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    NLR family proteins are cytoplasmic receptors responsible for the regulation of inflammation. Whereas some NLRs such as Cryopyrin form protein complexes recognizing pathogens and activating inflammation called the inflammasome; ...
  • Cloning, expression and purification of recombinant elongation factor Ts from hyperthermophilic bacteria Geobacillus Anatolicus 
    Şahin, Toros. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Elongation factor EF-Ts from Geobacillus anatolicus was cloned, expressed and purifed as a His-tagged recombinant protein in Escherichia coli. The first step in this study was the determination of the nucleic acid sequence ...
  • Studies on phosphorylation of elongation factor Tu in escherichia coli 
    Kaya, H. Özen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Protein synthesis is a vital process for living organisms. Synthesis of proteins are important for cell survival and reproduction. Protein synthesis takes place on ribosomes in all prokaryotic and eukaryotic cells. Amino ...
  • Unzipped mediates axon guidance of drosophila melamosgaster mushroom bodies through neuron-neuron and neuron - glia interactions 
    Çevrim, Bahadır Çağrı. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Drosophila mushroom body (MB) neuropil is the regulatory center for learning, memory, and many different behaviors. Besides its functional role, MB is a great model to investigate axon guidance dynamics. The MB consists ...
  • Identification of interferon regulatory factor 4 (IRF4) - interacting proteins in melanoma cell lines 
    Erkan, Ekin Ece. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    IRF4 is a member of interferon regulatory factor family of transcription factors. Previously, IRF4 was shown to have regulatory roles in immune cells and B-cell malignancies. In addition, IRF4 was recently shown to be ...
  • Expression analysis and behavioral assays in drosophila CMT models 
    Küey, Cansu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot–Marie–Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. It is characterized by progressive distal sensory loss and weakness, muscle atrophy in hands and lower legs, and ...
  • Functional and morphological evaluation of drosophila CMT models 
    Gökerküçük, Elif Begüm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot-Marie-Tooth (CMT) disease is the most frequent inherited peripheral neuropathy in humans with a prevalence of 1 in 2500. It comprises a large group of genetically heterogeneous hereditary motor and sensory neuropathies ...
  • Bioinformatic and molecular analysis of olfactory receptor gene regulation in zebrafish 
    Kaya, Ahmet Burak. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In vertebrates, an individual olfactory sensory neuron (OSN) expresses only one allele of one olfactory receptor (OR) gene from a huge genomic repertoire. The molecular mechanism governing “one neuron-one receptor rule” ...
  • Does blocking of firoblast growth factor-1 and its receptors affect mouse peripheral nerve myelination? 
    Şimşek, Büşra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Bi-directional communication between axon and Schwann cell is vital to the peripheral nervous system (PNS) myelination process. Disruption of this highly regulated communication is the main underlying reason of peripheral ...
  • In vivo characterization of the OR101-1 gene proximal promoter region in zebrafish 
    Kazcı, Yusuf E.. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In vertebrates, each olfactory sensory neuron (OSN) of the nose expresses only a single allele of a single molecular chemoreceptor gene from a large genomic repertoire. This monogenic mode of olfactory receptor (OR) ...
  • Regulation of olfactory receptor gene choice by negative regulatory elements 
    Sancer, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In the olfactory system, each olfactory sensory neuron (OSN) typically expresses only one allele of a single olfactory receptor (OR) gene from a vast genomic repertoire. The mechanisms of OR gene choice, however, are not ...
  • Identification of pathogenic mutations in neurodegenerative disorders: bioinformatic analysis of next generation sequencing data 
    Kartal, Ece. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and ataxias belong to a large group of disorders, characterized by progressive neuronal cell death in specific ...
  • Identification of the upstream regulators of interferon regulatory factor 4 (IRF4) expression in melanoma cells 
    Tufan, Ahmet Buğra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Melanoma is derived from melanin pigment producing cells which are known as melanocytes. Late stage, metastatic melanoma is considered as one of the most aggressive malignancies with one of the worst prognosis. IRF4 belongs ...
  • The possible involvement of SIK2 in diabetic retinopathy 
    Ersoy, Burcu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Diabetic Retinopathy (DR) is one of the most common complications of diabetes and in advanced stages it is characterized by vascular abnormalities and neuronal degeneration. It is widely accepted that the functional changes ...
  • Functional characterization of a novel hexosaminidase, CG7985, in DROSOPHILA eye development 
    Kıral, Ferdi Rıdvan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    CG7985 is one of the four hexosaminidases encoded by the Drosophila genome. Although the other three hexosaminidases have been well-characterized in terms of their enzymatic activities and metabolic pathways in which they ...