Boğaziçi Üniversitesi Tezleri: Recent submissions

  • Involvement of Gab1 in Müller cell proliferation 
    Dilvin Yıldırım, Hanife. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Müller cells, the major type of glial cells in the retina, are reactivated in response to most retinal injuries and diseases. In fish the reactivated Müller cells proliferate and transdifferentiate to make up for the lost ...
  • Investigation of in vitro and in vivo effects of ochratoxin a on autophagy and ubiquitin - proteasome system 
    Akpınar, Hafıze Ayşin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium genera of fungi and contaminates food and feed. OTA deregulates various signaling pathways and provokes oxidative stress along with augmentation of ...
  • Investigating the role of G protein coupled receptor (GPCR) activation in ochratoxin a (OTA)- induced toxicity 
    Aylan, Beren. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Ochratoxin A is recognized as a strong nephrotoxin accumulating and initiating cellular damage in kidney proximal tubule cells. OTA exerts its effects both on cell sur vival and cell death via the deregulation of mitogen ...
  • Characterization of adipokinetic hormone receptor in stick insect, Carausius Morosus 
    Sınmaz, Merve Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Adipokinetic hormone (AKH) is an insect neuropeptide and known as gonadotropinreleasing hormone, which is orthologue to humans. It is released from corpora cardiaca and acts generally on fat body for energy mobilization. ...
  • Investigation of NLRP13 - driven innate immune responses 
    Yılmazer, Açelya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    NOD-like receptors are the key players of inflammasome activation. NLRP13 is a primate specific member of the NLR family containing PYRIN domain and its role in inflammation is still unknown. Since there is no published ...
  • Investigation of the effects of NF-kB on ota induced apoptosis in HK-2 cell line 
    Gürkaşlar, Can. (Thesis (M.A.) - Bogazici University. Institute for Graduate Studies in the Social Sciences, 2018., 2018.)
    Ocharoxin A (OTA) is a mycotoxin produced by certain species of Aspergillus and Peni cillium genera of fungi. OTA was shown to be carcinogenic, genotoxic, immunotoxic by many studies and main suspected causative agent for ...
  • Molecular analysis of hemoglobinopathies and construction of a database; identification of a novel IVS-II-2 (T-A) mutation 
    Latif, Ayşe. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Hemoglobinopathies, inherited disorders of the hemoglobin (Hb) molecule, display great molecular and phenotypic diversity. Beta-thalassemia major is considered as the most severe form of hemoglobinopathies and requires ...
  • Transcriptome - wide analysis of iroc target genes in the drosophila olfactory system 
    Taşkıran, İbrahim İhsan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Sensing the environment is vital for an organism and it is provided by divergent sensory neurons. These neurons are generated from sensory organ precursor (SOP) cells that differentiate into neurons with diverse spectral ...
  • Clonal analysis of compensatory proliferation in dmHexDC mutants 
    Başdağ, Bilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Recycling of sugar-containing organic compounds (saccharides) have importance for metabolic activity, cellular growth, and differentiation. During this recycling process, many enzymes, primarily lysosomal enzymes, play a ...
  • Is FGF1 acting as a promoter of remyelination in peripheral nervous system? 
    Özkan, Nazmiye. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Bidirectional and continuous communication between Schwann cells (SCs) and axons are crucial for peripheral nervous system (PNS) myelin development, maintenance, and repair after injury. Disruption of SCs-axon interaction ...
  • Development of ASC specks as carriers / adjuvants for novel vaccine technology 
    Berber, Mesut. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Pathogen associated molecular patterns (PAMPs) and danger-associated molec ular patterns (DAMPs) are sensed by nucleotide binding oligomerization domain-like receptor (NLR) family of proteins in the cytosol. Certain NLRs ...
  • Determination of genetic diversity of rhododendron species in Turkey 
    Kaya, İsmail Tuğberk. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    The Rhododendrons of Turkey are presented by 10 taxa and they grow naturally along the coast of the Black Sea region from Artvin province at the east to Istranca Mountains at the west. Although in many countries, cultivated ...
  • GJB1 mutation screening and in vitro investigation of its upstream mutations 
    Arı, Oğuz. (Thesis (M.A.) - Bogazici University. Institute for Graduate Studies in the Social Sciences, 2017., 2017.)
    Charcot-Marie-Tooth Type 1X (CMTX1) is the X chromosome linked form of the disease and caused by mutations in the gap junction protein 1 (GJB1) gene. This gene is the second most commonly mutated gene in all CMT forms after ...
  • Investigation of motor neuron diseases by wes: genetic dissection of a Turkish ALS cohort 
    Akçimen, Fulya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is characterized by muscle weakness and atrophy due to the degeneration of motor neurons in the motor cortex, brain stem and spinal cord. Both ...
  • Analysis of positive and negative regulatory sites and their interacting transcription factors in the zebrafish OR101-1 gene promoter 
    Özdemir, Metin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Each olfactory sensory neuron (OSN) of olfactory system expresses a single allele of an olfactory receptor (OR) gene from a large genomic repertoire. How an OSN selects and activates a single OR allele is not well understood ...
  • The contribution of purinergic signaling to olfactory neurogenesis in zebrafish 
    Sakızlı, Uğurcan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Compared to other sensory epithelia, the olfactory epithelium (OE) has a remarkably high regenerative capacity: continuous neurogenesis compensates for regular turnover of olfactory sensory neurons (OSNs) while reactive ...
  • Characterization of yellow rust (Puccinia Striiformis) resistance in A F6 durum wheat population 
    Tufan, Hale Ann. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Nearly half of the agricultural land in Turkey is devoted to wheat. Turkey is one of the leading durum wheat producers in the Middle East and one of the most important biotic stress factors restricting the production is ...
  • Study of the polymerization dynamics of ASC and its domains 
    Kuzucu, Hulusi Onur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)
    Apoptosis-associated speck-like protein containing a CARD (ASC) is a 22 kDa protein composed of two conserved death-fold domains, PYD and CARD, that act as an adaptor protein in in ammasomes, multimolecular complexes that ...
  • Implementation of CRISPR based techologies for genome and gene expression maniplation of IRF4 in melanoma cells 
    Yerinde, Cansu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR/Cas9, which was originally characterized as an adaptive immune system in bacteria, has become the most powerful genome engineering technology in recent years ...
  • The molecular dissection of ataxias in Turkey and the impact of whole exome sequencing in their precise differential diagnosis 
    Koçoğlu, Cemile. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    Ataxias are a diverse group of genetically, clinically and mechanistically heterogeneous neurodegenerative disorders. There is significant overlap in the phenotype of different subtypes of ataxia, which can also manifest ...

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