G protein coupled receptors are a large family of cell surface receptors and are involved in a plethora of physiological functions from vision to various neuronal func tions. They have been a major target in the pharmaceutical ...

G-protein coupled receptors (GPCRs) are cell surface receptors that are consisted of seven-transmembrane α helices. Drugs targeting GPCRs account for one-third of clinically approved drugs; since many drugs target the ...

The purpose of this thesis is to investigate the allosteric coupling between intra- and extracellular parts of G-protein coupled human β2 adrenergic receptor (β2AR) in the presence of intracellular loop ICL3, which is ...