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  • Analysis of positive and negative regulatory sites and their interacting transcription factors in the zebrafish OR101-1 gene promoter 
    Özdemir, Metin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Each olfactory sensory neuron (OSN) of olfactory system expresses a single allele of an olfactory receptor (OR) gene from a large genomic repertoire. How an OSN selects and activates a single OR allele is not well understood ...
  • Bioinformatic and molecular analysis of olfactory receptor gene regulation in zebrafish 
    Kaya, Ahmet Burak. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In vertebrates, an individual olfactory sensory neuron (OSN) expresses only one allele of one olfactory receptor (OR) gene from a huge genomic repertoire. The molecular mechanism governing “one neuron-one receptor rule” ...
  • Cellular and molecular analysis of regenerative neurogenesis in the zebrafish (Danio rerio) olfactory epithelium 
    Kocagöz, Yiğit. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    The olfactory epithelium (OE) has a high regenerative capacity that ensures the lifelong replacement of olfactory sensory neurons (OSNs). Different modes of neurogen esis originate from the selective activity of two distinct ...
  • Class restriction in odorant receptor gene regulation 
    Tınaztepe, Emir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Odorant receptors which partake in the detection of both water-soluble and airborne chemicals constitute the largest family of seven-transmembrane G-Protein-Coupled Receptors in the majority of vertebrates. Since their ...
  • Co-expression of odorant receptor genes in zebrafish 
    Atasoy, Arif Murat. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Olfactory receptors constitute the largest G-Protein-Coupled Receptor family in humans and in other vertebrates. Olfactory receptor genes are expressed in the olfactory sensory neurons in the olfactory epithelia and are ...
  • Identification of HB-EGF positive and HB-EGF responsive cell populations in zebrafish olfactory epithelium 
    Güler, Kardelen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The peripheral olfactory epithelium (OE) is an exception to the limited capacity of the adult nervous system to undergo neurogenesis, which supports structural repair in response to traumatic injury. It continuously and ...
  • In vivo characterization of the OR101-1 gene proximal promoter region in zebrafish 
    Kazcı, Yusuf E.. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In vertebrates, each olfactory sensory neuron (OSN) of the nose expresses only a single allele of a single molecular chemoreceptor gene from a large genomic repertoire. This monogenic mode of olfactory receptor (OR) ...
  • Investigation of molecular signals regulating cell proliferation and neurogenesis in the intact and injured Zebrafish (Danio rerio) olfactory epithelium 
    Demirler, Mehmet Can. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)
    The zebrafish olfactory epithelium (OE) can recover from the near total loss of olfactory sensory neurons (OSNs) within only a week when the OE is damaged by external causes. This remarkable neurogenic activity depends ...
  • Neurogenesis and migration of specified chemosensory neurons in the adult zebrafish olfactory epithelium 
    Bayramlı, Khalid. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    In the framework of this study, a systematic and quantitative analysis of the neurogenic process and the integration of adult-born olfactory sensory neurons (OSNs) into the zebrafish olfactory epithelium (OE) was performed. ...
  • Olfactory neurogenesis following acute injury 
    Çapar, Serdar. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    For most of the last century, it was believed that neurogenesis is limited to embryonic development and does not occur in the adult nervous system. However, it is now an established fact that neurogenesis also occurs in ...
  • Regulation of olfactory receptor gene choice by negative regulatory elements 
    Sancer, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In the olfactory system, each olfactory sensory neuron (OSN) typically expresses only one allele of a single olfactory receptor (OR) gene from a vast genomic repertoire. The mechanisms of OR gene choice, however, are not ...
  • Selective neurogenesis in the zebrafish olfactory epithelium 
    Çoban, Büşra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Neurogenesis in the adult nervous system is a limited process in higher vertebrates. The olfactory epithelium (OE) is an exception to this limitation and maintains the ability to regenerate lost neurons throughout the ...
  • The contribution of purinergic signaling to olfactory neurogenesis in zebrafish 
    Sakızlı, Uğurcan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)
    Compared to other sensory epithelia, the olfactory epithelium (OE) has a remarkably high regenerative capacity: continuous neurogenesis compensates for regular turnover of olfactory sensory neurons (OSNs) while reactive ...
  • The role of EGFR and JAK 
    Alkiraz, Aysu Şevval. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The zebrafish olfactory epithelium (OE) has an exceptional neurogenic capacity, which supports the continuous turnover olfactory sensory neurons (OSNs) and efficient regeneration after injury. These processes depend on the ...
  • The role of MAPK and AKT signaling during zebrafish olfactory epithelium regeneration 
    Dokuzluoğlu, Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)
    The zebrafish olfactory epithelium (OE) is a neuroepithelium that is able to re generate neurons. The ability of the OE for neuron regeneration stems from the pres ence of a dual progenitor system that persists to the ...
  • The role of sustentacular cells in adult neurogenesis 
    Bali, Burak. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    The olfactory epithelium (OE) provides a unique exception to the limited ability of the nervous system to regenerate itself. Olfactory sensory neurons (OSN) are directly exposed to the outside world, prone to environmental ...
  • The role of theodorant receptor coding sequence in the regulation of odorant receptor transgene expression in Zebrafish 
    Taştekin, İbrahim. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Odorant receptors constitute the largest gene family in rodents and probably in all vertebrates. In addition to detecting the odorant molecules in the outside world, odorant receptorrs are responsible for some critical ...
  • The role of WNT signaling during regenerative neurogenesis in the zebrafish olfactory epithelium 
    Eski, Sema Elif. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    The peripheral olfactory epithelium (OE) is a potentially insightful exception to the limited capacity of neurogenesis in the adult nervous system. The OE undergoes continuous generation of olfactory sensory neurons (OSNs) ...
  • Transgenic analysis of the Zebrafish OR101-1 gene promoter 
    Söğünmez, Nuray. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    The repertoire of olfactory receptors constitutes the largest gene families in humans and in other vertebrates. Typically, olfactory sensory neurons only express a single member of the large genomic repertoire and only one ...
  • Validation of the OR103-1/5 intergenic sequence as a molecular tool to promote bi-cistronic translation in zebrafish 
    Uzel, Kerem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)
    Sensory neuron in the olfactory system, typically expresses only a single olfactory receptor (OR) gene from a large and diverse genomic repertoire. In zebrafish, a violation of this ‘one neuron – one receptor rule’ has ...