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Browsing by Subject "Fibroblast growth factors."

Browsing by Subject "Fibroblast growth factors."

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  • ERK, AKT and PKA as regulatory kinases of SIK2 in FGF signaling in muller cells 
    Ejder, Funda. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    FGF2 dependent retinal Müller cell proliferation is elicited mainly via activation of Ras/MAPK pathway. Phosphorylation/dephosphorylation of intermediates is one of the key mechanisms for the transient and rapid regulation ...
  • Expression of aFGF and FGF9 in the developing rat retina 
    Çayırlıoğlu, Pelin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Sciences and Engineering, 1995., 1997.)
    aFGF, an FGF gene family member, has been postulated to be important in the physiology and development of vertebrate retina. The distribution and relative levels of aFGF mRNA in the external photoreceptors layer, and in ...
  • Expression of fibroblast growth factors and their receptors in developing mouse dorsal root ganglia 
    Erkut, Cihan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Myelin is a key component of the nervous system where it discontinuously insulates axons and increases the speed of action potential propagation. The absence or insufficiency of myelin sheathing causes hereditary neuropathies. ...
  • Expression of SIK1 and SIK3 in postnatal rat retina 
    Vural, Muhammet Emin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Salt-inducible kinases (SIKs) have been shown to be expressed in various cells and organs including adrenocortical tissue, adipocytes and liver. They were implicated in adipocyte differentiation, steroidogenic gene expression ...
  • Identification of candidate substrates of SIK2 in vitro 
    Küser, Gamze. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    SIK2 is a serine/threonine kinase widely expressed in rat retina and it is postulated to be a potential regulator of FGF signal transduction in retina. The aim of this work is to explore a link between SIK2 and FGF/ERK ...
  • Involvement of Gab1 in Müller cell proliferation 
    Dilvin Yıldırım, Hanife. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)
    Müller cells, the major type of glial cells in the retina, are reactivated in response to most retinal injuries and diseases. In fish the reactivated Müller cells proliferate and transdifferentiate to make up for the lost ...
  • Involvement of SIK2 in FGF2 signal regulation via RAF-1 and generation of mutants for identification of phosphorylation sites on SIK2 by ERK 
    Akay, Özden. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)
    Müller cell proliferation is induced by FGF2 signaling via Ras/MAPK pathway through rapid and transient ERK1/2 activation. Salt inducible kinase 2 (SIK2), a serine/threonine kinase, is a novel regulator in this context. ...
  • Negative regulation of Müller reprogramming by SIK2 
    Uğurlu, Aslı. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)
    In fish it is well known that Müller cells proliferate, gain stem cell characteristics and generate new neurons upon injury. Proliferation is as essential step in retina regeneration and in mammals its tight regulation in ...
  • SIK2 expression in retinal cells and its possible involvement along with PKA in FGF9 signal transduction 
    Özmen, Yeşim. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    FGF signal transduction pathway activates a cascade of kinase and phosphatase dependent phosphorylation and dephosphorylation events. The pathway is subject to tight control mechanisms through negative feedback exerted by ...
  • SIK2 involvement in dowregulation of FGF signaling through Gab1 and Raf1 
    Sert, Yeliz Yılmaz. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)
    Proliferative response of Müller cells to FGF2 is propagated via Ras/MAPK pathway, and involves rapid and transient ERK1/2 activation. Results from our laboratory implicate SIK2 in the regulation of FGF2 signaling via ...
  • SIK2 is potential mediator of cross-talk between FGF and PKA pathways 
    Candaş, Demet. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)
    FGF signaling pathway is initiated upon FGF binding to RTKs and the signal transduction is achieved by a series of phosphorylation/dephosphorylation events mediated by several kinase and phosphatases. The pathway is tightly ...
  • SIK3 involvement in FGF2 signaling in Müller cells 
    Koca, Yıldız. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)
    FGF2 stimulation of Millier cells regulates several processes including cell proliferation and survival by triggering the activation RaslMAPK and PI3K1 Akt pathways. Data from our lab indicate that serine/threonine kinase ...

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